| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Patrick Mahomes | KC | 15.64 | 21.84 | 283.86 | 271 Pass, 8 Rush, 1 TD, 1 Int |
| RB | Najee Harris | Pit | 6.30 | 9.22 | 119.90 | 29 Rush, 19 Receiving, 3 Rec |
| RB | Bijan Robinson | Atl | 17.30 | 13.15 | 171.00 | 34 Rush, 54 Receiving, 5 Rec, 1 TD |
| WR | Puka Nacua | LAR | 11.50 | 13.95 | 181.40 | 6 Rush, 84 Receiving, 5 Rec |
| WR | Cooper Kupp | LAR | 21.50 | 10.58 | 95.20 | 115 Receiving, 8 Rec, 1 TD |
| WR | Josh Reynolds | Det | 11.90 | 7.22 | 93.90 | 44 Receiving, 3 Rec, 1 TD |
| TE | Jonnu Smith | Atl | 4.70 | 5.96 | 77.50 | 27 Receiving, 4 Rec |
| HB | Noah Brown | Hou | 0.00 | 8.61 | 60.30 | Played, No Stats |
| PK | Harrison Butker | KC | 5.00 | 8.46 | 110.00 | 1 FG(<40), 2 XP |
| DL | DeForest Buckner | Ind | 9.00 | 8.15 | 106.00 | 3 Tackles, 5 Assists, 1 PD |
| DL | David Onyemata | Atl | DNP | 6.18 | 68.00 | Did Not Play |
| DL | Christian Wilkins | Mia | 9.00 | 6.69 | 87.00 | 3 Tackles, 2 Assists, 1.0 Sack |
| LB | Cody Barton | Was | DNP | 8.78 | 79.00 | Team had a Bye |
| LB | Dre Greenlaw | SF | 4.00 | 8.42 | 101.00 | 2 Tackles, 2 Assists |
| LB | Ja'Whaun Bentley | NE | 7.00 | 9.00 | 108.00 | 2 Tackles, 5 Assists |
| CB | Jalen Ramsey | Mia | 3.00 | 5.17 | 31.00 | 1 Tackle, 1 Assist, 1 PD |
| S | Justin Simmons | Den | 14.00 | 7.82 | 86.00 | 3 Tackles, 3 Assists, 1.0 Sack, 1 FF, 1 PD |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Matthew Stafford | LAR | 0(29.66) | 19.11 | 229.28 | 294 Pass, -1 Rush, 3 TD |
| RB | Tyler Allgeier | Atl | 0(4.00) | 6.73 | 87.50 | 40 Rush |
| WR | Justin Watson | KC | 0(2.30) | 4.35 | 56.50 | 18 Receiving, 1 Rec |
| TE | Logan Thomas | Was | DNP | 6.93 | 83.10 | Team had a Bye |
| PK | Matt Ammendola | Hou | DNP | 7.25 | 29.00 | Did Not Play |
| DL | Leonard Floyd | Buf | 1.00 | 5.23 | 68.00 | 1 Tackle |
| LB | Henry To'oTo'o | Hou | 0 | 6.00 | 60.00 | Played, No Stats |
| CB | Tavierre Thomas | Hou | 0(1.00) | 6.22 | 56.00 | 1 Tackle |
| S | Amani Hooker | Ten | 0(6.00) | 7.83 | 94.00 | 4 Tackles, 1 Assist, 1 PD |
| Offense = 93.84 Defense = 47 Total = 140.84 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| WR | Darius Slayton | NYG | 2.40 | 5.22 | 67.90 | 14 Receiving, 2 Rec |
| WR | Demario Douglas | NE | DNP | 6.09 | 60.90 | Did Not Play |
| TE | Trey McBride | Ari | DNP | 7.77 | 101.00 | Team had a Bye |
| TE | Zach Ertz | Ari | DNP | 5.46 | 38.20 | Team had a Bye |
| DL | Will Anderson | Hou | 0.00 | 4.92 | 64.00 | Played, No Stats |
| LB | Denzel Perryman | Hou | 6.00 | 7.13 | 57.00 | 1 Tackle, 3 Assists, 2 PD |
| LB | Jordan Hicks | Min | DNP | 11.50 | 115.00 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| RB | Cam Akers | Min | DNP | 5.89 | 41.20 | Did Not Play |