| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Josh Allen | Buf | DNP | 29.52 | 442.76 | Did Not Play |
| RB | Raheem Mostert | Mia | 19.10 | 9.78 | 146.70 | 29 Rush, 62 Receiving, 8 Rec, 1 TD |
| RB | Josh Jacobs | LV | 17.50 | 18.55 | 296.80 | 69 Rush, 26 Receiving, 4 Rec, 1 TD |
| WR | Justin Jefferson | Min | 2.00 | 18.68 | 298.86 | 15 Receiving, 1 Rec |
| WR | Ja'Marr Chase | Cin | DNP | 16.57 | 182.30 | Did Not Play |
| WR | Davante Adams | LV | 30.80 | 17.23 | 275.70 | 153 Receiving, 7 Rec, 2 TD |
| TE | George Kittle | SF | 10.30 | 11.04 | 154.60 | 23 Receiving, 4 Rec, 1 TD |
| HB | CeeDee Lamb | Dal | 15.50 | 14.65 | 234.40 | 100 Receiving, 11 Rec |
| PK | Justin Tucker | Bal | 9.00 | 9.44 | 151.00 | 1 FG(<40), 1 FG(50-59), 1 XP |
| DL | Trey Hendrickson | Cin | DNP | 4.50 | 63.00 | Did Not Play |
| DL | Grover Stewart | Ind | 2.00 | 5.56 | 89.00 | 1 Tackle, 1 Assist |
| DL | Zach Sieler | Mia | 10.00 | 5.75 | 92.00 | 3 Tackles, 3 Assists, 1.0 Sack |
| LB | Matt Milano | Buf | DNP | 9.14 | 128.00 | Did Not Play |
| LB | Fred Warner | SF | 12.00 | 9.75 | 156.00 | 4 Tackles, 8 Assists |
| LB | Shaq Thompson | Car | 12.00 | 8.56 | 137.00 | 5 Tackles, 7 Assists |
| CB | Tariq Woolen | Sea | 11.00 | 7.50 | 120.00 | 4 Tackles, 3 Assists, 1 Fum Rcvy, 1 PD |
| S | Talanoa Hufanga | SF | 9.00 | 8.81 | 141.00 | 4 Tackles, 5 Assists |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Jared Goff | Det | 28.40 | 21.02 | 336.36 | 255 Pass, 2 Rush, 3 TD |
| RB | JaMycal Hasty | Jac | 0(14.60) | 3.72 | 59.50 | 33 Rush, 23 Receiving, 6 Rec, 1 TD |
| WR | Isaiah McKenzie | Buf | DNP | 6.85 | 95.90 | Did Not Play |
| TE | Tyler Conklin | NYJ | 0(11.00) | 6.25 | 100.00 | 80 Receiving, 6 Rec |
| DL | Brandon Graham | Phi | 11.00 | 5.25 | 84.00 | 2 Tackles, 1 Assist, 2.0 Sacks |
| LB | Jerome Baker | Mia | 6.00 | 7.50 | 120.00 | 3 Tackles, 2 Assists, 1 PD |
| S | Jalen Thompson | Ari | 0(10.00) | 7.38 | 118.00 | 8 Tackles, 2 Assists |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| WR | Romeo Doubs | GB | 3.50 | 6.80 | 81.60 | 20 Receiving, 3 Rec |
| Offense = 136.10 Defense = 73 Total = 209.10 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Brock Purdy | SF | 21.06 | 13.30 | 106.44 | 284 Pass, - 3 Rush, 2 TD, 1 Int |
| RB | Deon Jackson | Ind | 1.00 | 3.77 | 56.50 | 10 Rush |
| RB | D'Ernest Johnson | Cle | 0.00 | 0.28 | 3.90 | Played, No Stats |
| WR | Calvin Ridley | Jac | DNP | 0.00 | 0.00 | Did Not Play |
| WR | Julio Jones | TB | 2.80 | 5.84 | 58.40 | 13 Rush, 10 Receiving, 1 Rec |
| WR | DeAndre Hopkins | Ari | DNP | 13.41 | 120.70 | Did Not Play |
| DL | Rasheem Green | Hou | 1.00 | 3.73 | 56.00 | 1 Tackle |
| LB | Pete Werner | NO | 0.00 | 8.00 | 88.00 | Played, No Stats |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| RB | Clyde Edwards-Helaire | KC | DNP | 8.98 | 89.80 | Did Not Play |