| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Bailey Zappe | NE | 26.90 | 5.21 | 36.46 | 240 Pass, 13 Rush, 3 TD, 1 Int |
| RB | Samaje Perine | Den | 6.90 | 6.15 | 80.00 | 8 Rush, 36 Receiving, 5 Rec |
| RB | Clyde Edwards-Helaire | KC | 7.80 | 2.97 | 35.70 | 39 Rush, 29 Receiving, 2 Rec |
| WR | Ja'Marr Chase | Cin | 4.40 | 14.99 | 194.82 | 29 Receiving, 3 Rec |
| WR | Deebo Samuel | SF | 30.50 | 15.14 | 166.50 | 1 Rush, 149 Receiving, 7 Rec, 2 TD |
| WR | A.J. Brown | Phi | 12.90 | 16.29 | 211.80 | 94 Receiving, 9 Rec, 1 Fumb |
| TE | Pat Freiermuth | Pit | 5.30 | 6.09 | 48.70 | 18 Receiving, 3 Rec, 1 2-Pt |
| HB | Keaton Mitchell | Bal | 6.70 | 7.94 | 55.60 | 54 Rush, 8 Receiving, 1 Rec |
| PK | Chris Boswell | Pit | 6.00 | 7.92 | 103.00 | 1 FG(50-59), 1 XP |
| DL | Khalil Mack | LAC | 3.00 | 10.38 | 135.00 | 1 Tackle, 1 Assist, 1 PD |
| DL | Bradley Chubb | Mia | 9.00 | 7.46 | 97.00 | 2 Tackles, 3 Assists, 1 Fum Rcvy, 1 PD |
| DL | Derrick Brown | Car | 16.00 | 6.85 | 89.00 | 5 Tackles, 5 Assists, 1 Int, 1 PD |
| LB | Nick Bolton | KC | 9.00 | 8.60 | 43.00 | 5 Tackles, 3 Assists, 1 PD |
| LB | Divine Deablo | LV | 5.00 | 7.64 | 84.00 | 3 Tackles, 2 Assists |
| LB | Christian Harris | Hou | 13.00 | 6.67 | 80.00 | 7 Tackles, 3 Assists, 1 FF |
| CB | Brandon Stephens | Bal | 6.00 | 6.08 | 79.00 | 5 Tackles, 1 Assist |
| S | K'Von Wallace | Ten | 7.00 | 5.50 | 77.00 | 6 Tackles, 1 Assist |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| RB | Joshua Kelley | LAC | 0(0.60) | 4.33 | 56.30 | 6 Rush |
| WR | Khalil Shakir | Buf | 0(1.70) | 5.17 | 67.20 | 12 Receiving, 1 Rec |
| TE | Isaiah Likely | Bal | 0(16.80) | 2.78 | 36.20 | 83 Receiving, 5 Rec, 1 TD |
| LB | Tuli Tuipulotu | LAC | 0(4.00) | 4.85 | 63.00 | 3 Tackles, 1 Assist |
| Offense = 107.40 Defense = 68 Total = 175.40 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Burrow | Cin | DNP | 17.82 | 178.16 | Did Not Play |
| RB | Rico Dowdle | Dal | 11.70 | 5.30 | 68.90 | 46 Rush, 6 Receiving, 1 Rec, 1 TD |
| RB | Chase Brown | Cin | 18.00 | 3.36 | 26.90 | 25 Rush, 80 Receiving, 3 Rec, 1 TD |
| RB | Chris Rodriguez | Was | DNP | 1.40 | 15.40 | Team had a Bye |
| RB | Kenny McIntosh | Sea | 0.00 | 0.00 | 0.00 | Played, No Stats |
| RB | Jaleel McLaughlin | Den | 3.70 | 5.44 | 70.70 | 25 Rush, 7 Receiving, 1 Rec |
| RB | Zamir White | LV | 0.80 | 0.93 | 11.20 | 8 Rush |
| WR | Tank Dell | Hou | DNP | 12.86 | 141.50 | Did Not Play |
| WR | Tutu Atwell | LAR | 0.00 | 6.89 | 89.60 | Played, No Stats |
| WR | Josh Reynolds | Det | 11.90 | 7.22 | 93.90 | 44 Receiving, 3 Rec, 1 TD |
| DL | Zaven Collins | Ari | DNP | 4.31 | 56.00 | Team had a Bye |
| LB | Nakobe Dean | Phi | DNP | 6.20 | 31.00 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| RB | J.K. Dobbins | Bal | DNP | 0.00 | 0.00 | Did Not Play |