| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Gardner Minshew | Ind | 15.26 | 13.79 | 220.66 | 224 Pass, 3 Rush, 1 TD |
| RB | Travis Etienne | Jac | 24.80 | 15.01 | 240.20 | 102 Rush, 16 Receiving, 2 Rec, 2 TD |
| RB | Derrick Henry | Ten | 4.20 | 13.46 | 215.36 | 42 Rush |
| WR | DJ Chark | Car | 2.30 | 6.74 | 94.40 | 18 Receiving, 1 Rec |
| WR | Jakobi Meyers | LV | 8.60 | 11.00 | 164.98 | 56 Receiving, 6 Rec |
| WR | Deebo Samuel | SF | 15.70 | 14.96 | 209.50 | 35 Rush, 37 Receiving, 5 Rec, 1 TD |
| TE | Cade Otton | TB | 2.00 | 5.63 | 90.00 | 10 Receiving, 2 Rec |
| HB | Tony Pollard | Dal | 5.40 | 11.28 | 180.50 | 49 Rush, 1 Rec |
| PK | Justin Tucker | Bal | 8.00 | 9.69 | 155.00 | 8 XP |
| DL | Jonathon Cooper | Den | 5.00 | 7.88 | 126.00 | 1 Tackle, 1.0 Sack |
| DL | Jermaine Johnson | NYJ | 18.00 | 6.44 | 103.00 | 3 Tackles, 1 Int, 1 TD, 1 Fum Rcvy, 1 PD |
| DL | Zach Sieler | Mia | 12.00 | 7.44 | 119.00 | 3 Tackles, 2 Assists, 1.0 Sack, 1 FF |
| LB | Jordyn Brooks | Sea | DNP | 0.00 | 0.00 | Did Not Play |
| LB | Divine Deablo | LV | 3.00 | 7.50 | 105.00 | 2 Tackles, 1 Assist |
| LB | T.J. Edwards | Chi | 8.00 | 11.56 | 185.00 | 2 Tackles, 1 Int, 1 PD |
| CB | Paulson Adebo | NO | 5.00 | 8.43 | 118.00 | 3 Tackles, 1 Assist, 1 PD |
| S | Josh Metellus | Min | 7.00 | 8.94 | 143.00 | 6 Tackles, 1 Assist |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Tua Tagovailoa | Mia | 0(18.88) | 20.23 | 323.74 | 237 Pass, 14 Rush, 2 TD, 2 Int |
| RB | Khalil Herbert | Chi | 0(19.90) | 8.95 | 98.40 | 124 Rush, 5 Receiving, 2 Rec, 1 TD |
| WR | Tyler Boyd | Cin | 0(3.90) | 6.90 | 110.40 | 29 Receiving, 2 Rec |
| TE | Jonnu Smith | Atl | 0 | 5.61 | 89.80 | Played, No Stats |
| RB | Devin Singletary | Hou | 0(10.10) | 8.83 | 141.34 | 80 Rush, 6 Receiving, 3 Rec |
| PK | Nicholas Folk | Ten | 0(5.00) | 7.81 | 125.00 | 1 FG(50-59) |
| DL | Boye Mafe | Sea | 0(4.00) | 6.53 | 98.00 | 1 Tackle, 2 Assists, 1 PD |
| LB | Kaden Elliss | Atl | 13.00 | 8.63 | 138.00 | 6 Tackles, 3 Assists, 1.0 Sack |
| CB | L'Jarius Sneed | KC | 0(4.00) | 6.69 | 107.00 | 2 Tackles, 1 Assist, 1 PD |
| S | Julian Love | Sea | 0(17.00) | 9.63 | 154.00 | 10 Tackles, 4 Assists, 1 FF |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Tommy DeVito | NYG | 0 | 10.00 | 109.98 | Played, No Stats |
| RB | Tyjae Spears | Ten | 0(4.90) | 6.73 | 107.70 | 29 Receiving, 4 Rec |
| WR | Kalif Raymond | Det | 0(1.60) | 4.62 | 73.90 | 11 Receiving, 1 Rec |
| WR | Justin Watson | KC | 0(4.60) | 4.78 | 76.50 | 41 Receiving, 1 Rec |
| LB | Drue Tranquill | KC | 0(1.00) | 6.80 | 102.00 | 1 Tackle |
| S | Harrison Smith | Min | 0(5.00) | 7.06 | 113.00 | 3 Tackles, 2 Assists |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| WR | Mike Williams | LAC | DNP | 13.57 | 40.70 | Did Not Play |