| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Trevor Lawrence | Jac | 18.66 | 19.93 | 279.00 | 264 Pass, 41 Rush, 1 TD, 2 Fumb |
| RB | Austin Ekeler | LAC | 5.80 | 12.81 | 140.90 | 9 Rush, 29 Receiving, 4 Rec |
| RB | Breece Hall | NYJ | 2.30 | 11.74 | 164.30 | 12 Rush, 6 Receiving, 1 Rec |
| WR | Brandon Aiyuk | SF | 5.20 | 13.35 | 173.50 | 37 Receiving, 3 Rec |
| WR | Cooper Kupp | LAR | 21.10 | 11.63 | 116.30 | 111 Receiving, 8 Rec, 1 TD |
| WR | Michael Pittman | Ind | 9.80 | 12.84 | 179.70 | 78 Receiving, 4 Rec |
| TE | Cade Otton | TB | 5.40 | 6.20 | 86.80 | 44 Receiving, 2 Rec |
| HB | Zack Moss | Ind | 10.80 | 11.78 | 153.10 | 13 Rush, 20 Receiving, 3 Rec, 1 TD |
| PK | Blake Grupe | NO | 8.00 | 8.71 | 122.00 | 1 FG(50-59), 3 XP |
| DL | Nick Bosa | SF | 8.00 | 6.93 | 97.00 | 1 Tackle, 1.0 Sack, 1 FF |
| DL | Khalil Mack | LAC | 5.00 | 10.00 | 140.00 | 2 Tackles, 1 Assist, 2 PD |
| DL | Montez Sweat | Chi | 20.00 | 8.00 | 112.00 | 5 Tackles, 2 Assists, 2.5 Sacks, 1 FF |
| LB | Christian Harris | Hou | 8.00 | 6.77 | 88.00 | 7 Tackles, 1 Assist |
| LB | C.J. Mosley | NYJ | 7.00 | 10.50 | 147.00 | 5 Tackles, 2 Assists |
| LB | Jeremiah Owusu-Koramoah | Cle | 17.00 | 7.86 | 110.00 | 6 Tackles, 1.0 Sack, 1 Int, 2 PD |
| CB | Jason Pinnock | NYG | 12.00 | 7.86 | 110.00 | 7 Tackles, 1 Assist, 1.0 Sack |
| S | Josh Metellus | Min | 9.00 | 9.00 | 126.00 | 5 Tackles, 1.0 Sack |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Matthew Stafford | LAR | 0(22.52) | 19.37 | 251.80 | 258 Pass, 2 Rush, 2 TD |
| RB | Gus Edwards | Bal | 0(13.40) | 10.99 | 153.90 | 58 Rush, 11 Receiving, 1 Rec, 1 TD |
| WR | Odell Beckham | Bal | 0(1.90) | 7.08 | 84.90 | 14 Receiving, 1 Rec |
| WR | Rashid Shaheed | NO | 0(5.10) | 8.94 | 107.30 | 36 Receiving, 3 Rec |
| DL | Zach Allen | Den | 0 | 5.21 | 73.00 | Played, No Stats |
| LB | Micah McFadden | NYG | 0(6.00) | 8.15 | 106.00 | 5 Tackles, 1 Assist |
| S | Kamren Curl | Was | 0(8.00) | 8.36 | 117.00 | 1 Tackle, 4 Assists, 1 Fum Rcvy |
| Offense = 87.06 Defense = 86 Total = 173.06 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Zach Charbonnet | Sea | 1.60 | 0.00 | 0.00 | |
| RB | D'Onta Foreman | Chi | -0.60 | 9.52 | 85.70 | -6 Rush |
| RB | Jerick McKinnon | KC | 16.66 | 6.16 | 73.96 | 4 Pass, 11 Rush, 19 Receiving, 3 Rec, 2 TD |
| RB | Samaje Perine | Den | 5.30 | 6.09 | 85.30 | 37 Rush, 11 Receiving, 1 Rec |
| WR | Tutu Atwell | LAR | DNP | 6.89 | 89.60 | Did Not Play |
| WR | Marquise Brown | Ari | 0.00 | 7.80 | 109.20 | Played, No Stats |
| WR | Chris Godwin | TB | 20.50 | 9.48 | 132.70 | 155 Receiving, 10 Rec |
| TE | Logan Thomas | Was | 1.20 | 6.48 | 84.30 | 7 Receiving, 1 Rec |
| LB | Shaquille Leonard | Phi | 4.00 | 0.00 | 0.00 | |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| WR | Josh Palmer | LAC | 19.30 | 9.19 | 73.50 | |