| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Kyler Murray | Ari | 19.78 | 20.80 | 166.36 | 262 Pass, 33 Rush, 1 TD |
| RB | Gus Edwards | Bal | 3.80 | 10.76 | 183.00 | 48 Rush, 1 Fumb |
| RB | Breece Hall | NYJ | 28.00 | 14.85 | 252.50 | 178 Rush, 12 Receiving, 2 Rec, 1 TD, 1 2-Pt |
| WR | Stefon Diggs | Buf | 12.20 | 13.02 | 221.30 | 87 Receiving, 7 Rec |
| WR | CeeDee Lamb | Dal | 29.00 | 19.86 | 337.70 | 7 Rush, 98 Receiving, 13 Rec, 2 TD |
| WR | Garrett Wilson | NYJ | 4.40 | 9.86 | 167.70 | 34 Receiving, 2 Rec |
| TE | Tucker Kraft | GB | 4.60 | 3.71 | 63.00 | 31 Receiving, 3 Rec |
| HB | Deebo Samuel | SF | 4.20 | 14.25 | 213.70 | 11 Rush, 21 Receiving, 2 Rec |
| PK | Greg Zuerlein | NYJ | 10.00 | 8.81 | 141.00 | 2 FG(<40), 1 FG(40-49) |
| DL | Jonathon Cooper | Den | 2.00 | 7.53 | 128.00 | 2 Assists |
| DL | T.J. Watt | Pit | 16.00 | 10.82 | 184.00 | 6 Tackles, 2 Assists, 2.0 Sacks |
| DL | Christian Wilkins | Mia | 15.00 | 6.71 | 114.00 | 5 Tackles, 1.0 Sack, 1 FF, 1 Fum Rcvy |
| LB | Zaire Franklin | Ind | 9.00 | 12.44 | 199.00 | 3 Tackles, 6 Assists |
| LB | Foyesade Oluokun | Jac | 7.00 | 12.53 | 213.00 | 3 Tackles, 4 Assists |
| LB | Logan Wilson | Cin | 11.00 | 10.53 | 179.00 | 2 Tackles, 3 Assists, 1 Int, 1 PD |
| CB | Paulson Adebo | NO | 8.00 | 8.40 | 126.00 | 4 Tackles, 3 Assists, 1 PD |
| S | Dax Hill | Cin | 5.00 | 7.94 | 135.00 | 4 Tackles, 1 Assist |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Flacco | Cle | 0 | 15.98 | 127.84 | Played, No Stats |
| RB | Latavius Murray | Buf | DNP | 4.65 | 74.40 | Did Not Play |
| WR | DeVante Parker | NE | 0(1.10) | 4.30 | 55.90 | 6 Receiving, 1 Rec |
| TE | Hunter Henry | NE | DNP | 7.06 | 98.90 | Did Not Play |
| RB | Joshua Kelley | LAC | 0(0.10) | 3.45 | 58.70 | 1 Rush |
| DL | Cameron Jordan | NO | 0(3.00) | 3.35 | 57.00 | 1 Tackle, 2 Assists |
| LB | Alex Anzalone | Det | 0(9.00) | 9.31 | 149.00 | 8 Tackles, 1 Assist |
| CB | Tre Brown | Sea | 0(1.00) | 4.40 | 66.00 | 1 Tackle |
| S | Jalen Pitre | Hou | 0(7.00) | 6.13 | 92.00 | 4 Tackles, 3 Assists |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| LB | Drue Tranquill | KC | 0 | 6.38 | 102.00 | Played, No Stats |
| Offense = 115.98 Defense = 73 Total = 188.98 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Anthony Richardson | Ind | DNP | 19.92 | 79.68 | Did Not Play |
| RB | J.K. Dobbins | Bal | DNP | 0.00 | 0.00 | Did Not Play |
| RB | Zach Evans | LAR | 0.30 | 0.17 | 1.90 | 3 Rush |
| RB | Zack Moss | Ind | 3.00 | 11.15 | 156.10 | 30 Rush |
| WR | Michael Gallup | Dal | 0.00 | 4.16 | 70.80 | Played, No Stats |
| TE | T.J. Hockenson | Min | DNP | 0.00 | 0.00 | Did Not Play |