| Round | Overall | Player |
|---|---|---|
| 1 | 8th | QB Peyton Manning Ind |
| 2 | 17th | RB Maurice Jones-Drew Jac |
| 3 | 32nd | RB Clinton Portis Was |
| 4 | 41st | RB Brandon Jacobs NYG |
| 5 | 56th | WR Calvin Johnson Det |
| 6 | 65th | TE Kellen Winslow Jr. Cle |
| 7 | 80th | WR Braylon Edwards Cle |
| 8 | 89th | QB Matt Leinart F/A |
| 9 | 104th | RB Warrick Dunn Atl |
| 10 | 113th | LB Kirk Morrison Oak |
| 11 | 128th | WR Kevin Curtis Phi |
| 12 | 137th | LB Adalius Thomas NE |
| 13 | 152nd | RB Kevin Jones Det |
| 14 | 161st | DL Derrick Burgess Oak |
| 15 | 176th | QB Byron Leftwich Atl |
| 16 | 185th | WR Isaac Bruce StL |
| 17 | 200th | RB Chris Brown Ten |
| 18 | 209th | TE Eric Johnson NO |
| 19 | 224th | PK Neil Rackers Ari |
| 20 | 233rd | S Donte Whitner Buf |
| 21 | 248th | WR Troy Williamson Min |
| 22 | 257th | DL James Hall StL |
| 23 | 272nd | CB Charles Woodson GB |
| 24 | 281st | LB Dan Morgan Car |
| 25 | 296th | PK Olindo Mare NO |
| 26 | 305th | S Rodney Harrison NE |
| 27 | 320th | DL Aaron Smith Pit |
| 28 | 329th | CB Anthony Henry Dal |