| Round | Overall | Player |
|---|---|---|
| 1 | 7th | RB Reggie Bush NO |
| 2 | 18th | WR Chad Johnson Cin |
| 3 | 31st | TE Antonio Gates SD |
| 4 | 42nd | WR Andre Johnson Hou |
| 5 | 55th | RB Ahman Green Hou |
| 6 | 66th | QB Philip Rivers SD |
| 7 | 79th | LB Shawne Merriman SD |
| 8 | 90th | DL Aaron Schobel Buf |
| 9 | 103rd | S Sean Jones Cle |
| 10 | 114th | RB LaMont Jordan Oak |
| 11 | 127th | DL Robert Mathis Ind |
| 12 | 138th | QB Alex Smith SF |
| 13 | 151st | LB Adalius Thomas NE |
| 14 | 162nd | WR James Jones GB |
| 15 | 175th | TE Randy McMichael StL |
| 16 | 186th | CB Dunta Robinson Hou |
| 17 | 199th | PK Jeff Wilkins StL |
| 18 | 210th | LB Patrick Willis SF |
| 19 | 223rd | DL Mike Strahan NYG |
| 20 | 234th | WR Jacoby Jones Hou |
| 21 | 247th | S Ken Hamlin Dal |
| 22 | 258th | RB Adrian Peterson Chi |
| 23 | 271st | PK Josh Brown Sea |
| 24 | 282nd | QB Jeff Garcia TB |
| 25 | 295th | RB Tony Hunt Phi |
| 26 | 306th | S Erik Coleman NYJ |
| 27 | 319th | WR Steve Smith NYG |
| 28 | 330th | CB Chris Gamble Car |