| Round | Overall | Player |
|---|---|---|
| 1 | 8th | RB Frank Gore SF |
| 2 | 17th | RB Shonn Greene NYJ |
| 3 | 32nd | WR Michael Crabtree SF |
| 4 | 41st | WR Marques Colston NO |
| 5 | 56th | TE Antonio Gates SD |
| 6 | 65th | RB Darren McFadden Oak |
| 7 | 80th | LB Rolando McClain Oak |
| 8 | 89th | QB Brett Favre Ret |
| 9 | 104th | RB Donald Brown Ind |
| 10 | 113th | QB Eli Manning NYG |
| 11 | 128th | WR Demaryius Thomas Den |
| 12 | 137th | QB Sam Bradford StL |
| 13 | 152nd | DL John Abraham Atl |
| 14 | 161st | PK Nate Kaeding SD |
| 15 | 176th | DL Tamba Hali KC |
| 16 | 185th | RB Ben Tate Hou |
| 17 | 200th | CB Brandon Flowers KC |
| 18 | 209th | S Antoine Bethea Ind |
| 19 | 224th | LB Clay Matthews GB |
| 20 | 233rd | LB Brian Orakpo Was |
| 21 | 248th | WR Louis Murphy Oak |
| 22 | 257th | WR Jacoby Jones Hou |
| 23 | 272nd | WR Austin Collie Ind |
| 24 | 281st | TE Kevin Boss NYG |
| 25 | 296th | LB A.J. Hawk GB |
| 26 | 305th | PK Dan Carpenter Mia |
| 27 | 320th | DL Cliff Avril Det |
| 28 | 329th | LB Jon Alston TB |