| Round | Overall | Player |
|---|---|---|
| 1 | 3rd | QB Drew Brees NO |
| 2 | 22nd | LB Patrick Willis SF |
| 3 | 27th | RB Jahvid Best Det |
| 4 | 46th | RB Matt Forte Chi |
| 5 | 51st | WR Dez Bryant Dal |
| 6 | 70th | LB Brian Cushing Hou |
| 7 | 75th | WR Vincent Jackson SD |
| 8 | 94th | S Tyvon Branch Oak |
| 9 | 99th | DL Trent Cole Phi |
| 10 | 118th | S Eric Weddle SD |
| 11 | 123rd | WR Devery Henderson NO |
| 12 | 142nd | DL Aaron Schobel Buf |
| 13 | 147th | TE Tony Gonzalez Atl |
| 14 | 166th | WR Braylon Edwards NYJ |
| 15 | 171st | RB Fred Jackson Buf |
| 16 | 190th | LB David Hawthorne Sea |
| 17 | 195th | S Brandon Meriweather NE |
| 18 | 214th | CB Terrell Thomas NYG |
| 19 | 219th | DL Calais Campbell Ari |
| 20 | 238th | RB Toby Gerhart Min |
| 21 | 243rd | WR Derrick Mason Bal |
| 22 | 262nd | QB Trent Edwards Jac |
| 23 | 267th | PK Matt Prater Den |
| 24 | 286th | PK Robbie Gould Chi |
| 25 | 291st | RB Brian Westbrook SF |
| 26 | 310th | LB Dhani Jones Cin |
| 27 | 315th | TE Fred Davis Was |
| 28 | 334th | WR Legedu Naanee SD |