| Round | Overall | Player |
|---|---|---|
| 1 | 12th | RB DeAngelo Williams Car |
| 2 | 13th | QB Philip Rivers SD |
| 3 | 36th | RB Jamaal Charles KC |
| 4 | 37th | DL Jared Allen Min |
| 5 | 60th | TE Brent Celek Phi |
| 6 | 61st | LB James Laurinaitis StL |
| 7 | 84th | WR Pierre Garcon Ind |
| 8 | 85th | WR Robert Meachem NO |
| 9 | 108th | QB Jay Cutler Chi |
| 10 | 109th | RB Justin Forsett Sea |
| 11 | 132nd | LB Jonathan Vilma NO |
| 12 | 133rd | PK Garrett Hartley NO |
| 13 | 156th | DL Robert Mathis Ind |
| 14 | 157th | CB Charles Tillman Chi |
| 15 | 180th | WR Kenny Britt Ten |
| 16 | 181st | S Eric Berry KC |
| 17 | 204th | WR Lee Evans Buf |
| 18 | 205th | DL Brandon Graham Phi |
| 19 | 228th | TE Tony Scheffler Det |
| 20 | 229th | S Kerry Rhodes Ari |
| 21 | 252nd | CB Dunta Robinson Atl |
| 22 | 253rd | LB Daryl Washington Ari |
| 23 | 276th | RB Rashad Jennings Jac |
| 24 | 277th | PK Graham Gano Was |
| 25 | 300th | WR Brian Hartline Mia |
| 26 | 301st | QB Dennis Dixon Pit |
| 27 | 324th | LB Sean Weatherspoon Atl |
| 28 | 325th | S Nate Allen Phi |