| Round | Overall | Player |
|---|---|---|
| 1 | 8th | QB Drew Brees NO |
| 2 | 17th | WR Reggie Wayne Ind |
| 3 | 32nd | RB Ronnie Brown Phi |
| 4 | 41st | RB Knowshon Moreno Den |
| 5 | 56th | WR Percy Harvin Min |
| 6 | 65th | RB Reggie Bush Mia |
| 7 | 80th | WR Donald Driver GB |
| 8 | 89th | TE Owen Daniels Hou |
| 9 | 104th | RB Jerome Harrison Phi |
| 10 | 113th | WR Mike Williams TB |
| 11 | 128th | LB Demarcus Ware Dal |
| 12 | 137th | LB Karlos Dansby Mia |
| 13 | 152nd | QB Kyle Orton Den |
| 14 | 161st | RB Chester Taylor Chi |
| 15 | 176th | S Louis Delmas Det |
| 16 | 185th | DL Darnell Dockett Ari |
| 17 | 200th | WR Mohamed Massaquoi Cle |
| 18 | 209th | RB Larry Johnson Was |
| 19 | 224th | PK Mason Crosby GB |
| 20 | 233rd | LB Stewart Bradley Phi |
| 21 | 248th | TE Aaron Hernandez NE |
| 22 | 257th | QB Sam Bradford StL |
| 23 | 272nd | CB Johnathan Joseph Cin |
| 24 | 281st | WR Mardy Gilyard StL |
| 25 | 296th | DL John Abraham Atl |
| 26 | 305th | S Jairus Byrd Buf |
| 27 | 320th | WR Golden Tate Sea |
| 28 | 329th | DL Connor Barwin Hou |