| Round | Overall | Player |
|---|---|---|
| 1 | 9th | WR Andre Johnson Hou |
| 2 | 16th | RB Shonn Greene NYJ |
| 3 | 33rd | RB Jamaal Charles KC |
| 4 | 40th | LB Patrick Willis SF |
| 5 | 57th | QB Kevin Kolb Ari |
| 6 | 64th | LB Barrett Ruud TB |
| 7 | 81st | WR Pierre Garcon Ind |
| 8 | 88th | LB Terrell Suggs Bal |
| 9 | 105th | DL Robert Mathis Ind |
| 10 | 112th | TE Owen Daniels Hou |
| 11 | 129th | RB Ricky Williams Mia |
| 12 | 136th | WR Eddie Royal Den |
| 13 | 153rd | S Eric Weddle SD |
| 14 | 160th | WR Anthony Gonzalez Ind |
| 15 | 177th | QB Mark Sanchez NYJ |
| 16 | 184th | DL Aaron Schobel Buf |
| 17 | 201st | DL Stylez White TB |
| 18 | 208th | LB Brian Orakpo Was |
| 19 | 225th | PK Ryan Longwell Min |
| 20 | 232nd | CB Champ Bailey Den |
| 21 | 249th | QB Jason Campbell Oak |
| 22 | 256th | TE Dustin Keller NYJ |
| 23 | 273rd | DL Calais Campbell Ari |
| 24 | 280th | LB LaMarr Woodley Pit |
| 25 | 297th | WR Demaryius Thomas Den |
| 26 | 304th | RB Mewelde Moore Pit |
| 27 | 321st | PK Jeff Reed SF |
| 28 | 328th | S Kerry Rhodes Ari |