| Round | Overall | Player |
|---|---|---|
| 1 | 11th | QB Cam Newton Car |
| 2 | 14th | RB Adrian Peterson Min |
| 3 | 35th | WR Steve Smith Car |
| 4 | 38th | RB Trent Richardson Cle |
| 5 | 59th | RB Doug Martin TB |
| 6 | 62nd | WR Mike Wallace Pit |
| 7 | 83rd | QB Ben Roethlisberger Pit |
| 8 | 86th | LB London Fletcher Was |
| 9 | 107th | LB Derrick Johnson KC |
| 10 | 110th | TE Owen Daniels Hou |
| 11 | 131st | S Troy Polamalu Pit |
| 12 | 134th | CB Charles Woodson GB |
| 13 | 155th | PK David Akers SF |
| 14 | 158th | CB Charles Tillman Chi |
| 15 | 179th | TE Brent Celek Phi |
| 16 | 182nd | S Roman Harper NO |
| 17 | 203rd | DL Ahtyba Rubin Cle |
| 18 | 206th | DL Geno Atkins Cin |
| 19 | 227th | WR Randy Moss SF |
| 20 | 230th | WR Jonathan Baldwin KC |
| 21 | 251st | RB Tim Hightower F/A |
| 22 | 254th | WR Nate Burleson F/A |
| 23 | 275th | QB Mark Sanchez NYJ |
| 24 | 278th | PK Dan Carpenter Mia |
| 25 | 299th | LB James Anderson Car |
| 26 | 302nd | DL Vince Wilfork NE |
| 27 | 323rd | WR Kevin Walter Hou |
| 28 | 326th | RB Mike Tolbert Car |