| Round | Overall | Player |
|---|---|---|
| 1 | 12th | QB Matthew Stafford Det |
| 2 | 13th | TE Rob Gronkowski NE |
| 3 | 36th | WR Dwayne Bowe KC |
| 4 | 37th | WR DeSean Jackson F/A |
| 5 | 60th | LB Patrick Willis SF |
| 6 | 61st | RB Donald Brown F/A |
| 7 | 84th | RB Beanie Wells Ari |
| 8 | 85th | LB James Laurinaitis StL |
| 9 | 108th | DL Trent Cole Phi |
| 10 | 109th | WR Reggie Wayne Ind |
| 11 | 132nd | RB Roy Helu F/A |
| 12 | 133rd | DL Osi Umenyiora NYG |
| 13 | 156th | RB Shane Vereen NE |
| 14 | 157th | S Morgan Burnett GB |
| 15 | 180th | QB Alex Smith SF |
| 16 | 181st | PK Garrett Hartley NO |
| 17 | 204th | LB James Harrison Pit |
| 18 | 205th | WR Darrius Heyward-Bey Oak |
| 19 | 228th | DL Matt Shaughnessy Oak |
| 20 | 229th | S William Moore Atl |
| 21 | 252nd | QB Matt Flynn Sea |
| 22 | 253rd | WR Jerome Simpson Min |
| 23 | 276th | CB Alterraun Verner Ten |
| 24 | 277th | LB David Hawthorne NO |
| 25 | 300th | TE Ed Dickson Bal |
| 26 | 301st | RB Ronnie Brown SD |
| 27 | 324th | PK Rob Bironas Ten |
| 28 | 325th | DL Tommy Kelly Oak |