| Round | Overall | Player |
|---|---|---|
| 1 | 6th | QB Drew Brees NO |
| 2 | 19th | WR Roddy White Atl |
| 3 | 30th | RB Trent Richardson Cle |
| 4 | 43rd | WR Brandon Lloyd NE |
| 5 | 54th | LB Patrick Willis SF |
| 6 | 67th | TE Jermichael Finley GB |
| 7 | 78th | RB Roy Helu F/A |
| 8 | 91st | RB Beanie Wells Ari |
| 9 | 102nd | WR Robert Meachem SD |
| 10 | 115th | RB Mikel LeShoure Det |
| 11 | 126th | DL Jason Babin Jac |
| 12 | 139th | CB DeAngelo Hall Was |
| 13 | 150th | LB Brian Cushing F/A |
| 14 | 163rd | WR Lance Moore NO |
| 15 | 174th | LB Von Miller Den |
| 16 | 187th | TE Owen Daniels Hou |
| 17 | 198th | QB Alex Smith SF |
| 18 | 211th | S Antrel Rolle NYG |
| 19 | 222nd | PK Matt Bryant Atl |
| 20 | 235th | WR Jerome Simpson Min |
| 21 | 246th | RB Evan Royster Was |
| 22 | 259th | DL Kyle Vanden Bosch Det |
| 23 | 270th | WR Emmanuel Sanders Pit |
| 24 | 283rd | CB William Gay Ari |
| 25 | 294th | S Edward Reed Bal |
| 26 | 307th | RB Montario Hardesty Cle |
| 27 | 318th | WR Earl Bennett Chi |
| 28 | 331st | DL Mike DeVito NYJ |