| Round | Overall | Player |
|---|---|---|
| 1 | 11th | RB C.J. Spiller Buf |
| 2 | 14th | RB Matt Forte Chi |
| 3 | 35th | WR Vincent Jackson TB |
| 4 | 38th | WR Wesley Welker Den |
| 5 | 59th | RB Frank Gore SF |
| 6 | 62nd | WR Eric Decker Den |
| 7 | 83rd | WR T.Y. Hilton Ind |
| 8 | 86th | QB Eli Manning NYG |
| 9 | 107th | DL Greg Hardy Car |
| 10 | 110th | DL Anthony Spencer F/A |
| 11 | 131st | LB Lawrence Timmons Pit |
| 12 | 134th | TE Antonio Gates SD |
| 13 | 155th | QB Andy Dalton Cin |
| 14 | 158th | S Tyvon Branch Oak |
| 15 | 179th | LB Aldon Smith SF |
| 16 | 182nd | RB Ronnie Hillman Den |
| 17 | 203rd | CB Jason McCourty Ten |
| 18 | 206th | RB Fred Jackson Buf |
| 19 | 227th | DL John Abraham Ari |
| 20 | 230th | LB Karlos Dansby Ari |
| 21 | 251st | WR Malcom Floyd F/A |
| 22 | 254th | PK Matt Prater Den |
| 23 | 275th | LB Lance Briggs Chi |
| 24 | 278th | CB Antoine Winfield Ret |
| 25 | 299th | DL Vince Wilfork F/A |
| 26 | 302nd | TE Brent Celek Phi |
| 27 | 323rd | S Donte Whitner SF |
| 28 | 326th | PK Robbie Gould Chi |