| Round | Overall | Player |
|---|---|---|
| 1 | 11th | WR Calvin Johnson Det |
| 2 | 14th | TE Jimmy Graham NO |
| 3 | 35th | RB Frank Gore SF |
| 4 | 38th | RB DeMarco Murray Dal |
| 5 | 59th | WR Hakeem Nicks NYG |
| 6 | 62nd | QB Robert Griffin III Was |
| 7 | 83rd | DL Jason Pierre-Paul NYG |
| 8 | 86th | DL Anthony Spencer F/A |
| 9 | 107th | WR Kenbrell Thompkins NE |
| 10 | 110th | RB Chris Ivory NYJ |
| 11 | 131st | WR Michael Floyd Ari |
| 12 | 134th | LB Kiko Alonso Buf |
| 13 | 155th | QB Philip Rivers SD |
| 14 | 158th | WR Cordarrelle Patterson Min |
| 15 | 179th | RB Roy Helu Was |
| 16 | 182nd | WR Markus Wheaton Pit |
| 17 | 203rd | RB Kendall Hunter SF |
| 18 | 206th | LB Jon Bostic Chi |
| 19 | 227th | S Johnathan Cyprien Jac |
| 20 | 230th | RB Christine Michael Sea |
| 21 | 251st | DL Cliff Avril Sea |
| 22 | 254th | LB Nick Roach Oak |
| 23 | 275th | QB E.J. Manuel Buf |
| 24 | 278th | PK Randy Bullock Hou |
| 25 | 299th | RB Robert Turbin Sea |
| 26 | 302nd | RB Joseph Randle Dal |
| 27 | 323rd | CB Johnthan Banks TB |
| 28 | 326th | RB Mike Goodson F/A |