| Round | Overall | Player |
|---|---|---|
| 1 | 3rd | RB Christian McCaffrey SF |
| 2 | 22nd | RB Leonard Fournette TB |
| 3 | 27th | RB James Conner Ari |
| 4 | 46th | QB Patrick Mahomes KC |
| 5 | 51st | TE George Kittle SF |
| 6 | 70th | RB Josh Jacobs LV |
| 7 | 75th | WR Hunter Renfrow LV |
| 8 | 94th | WR Allen Lazard GB |
| 9 | 99th | WR Chase Claypool Chi |
| 10 | 118th | LB Roquan Smith Bal |
| 11 | 123rd | WR Tyler Lockett Sea |
| 12 | 142nd | LB Logan Wilson Cin |
| 13 | 147th | DL Marcus Davenport NO |
| 14 | 166th | WR George Pickens Pit |
| 15 | 171st | DL Chandler Jones LV |
| 16 | 190th | DL Christian Wilkins Mia |
| 17 | 195th | LB Deion Jones Cle |
| 18 | 214th | RB Ronald Jones KC |
| 19 | 219th | WR Marvin Jones Jac |
| 20 | 238th | PK Evan McPherson Cin |
| 21 | 243rd | QB Baker Mayfield LAR |
| 22 | 262nd | DL Arik Armstead SF |
| 23 | 267th | LB Kyzir White Phi |
| 24 | 286th | S Kyle Dugger NE |
| 25 | 291st | TE Noah Fant Sea |
| 26 | 310th | S Johnathan Abram Sea |
| 27 | 315th | QB Deshaun Watson Cle |
| 28 | 334th | WR Kendrick Bourne NE |
| 29 | 339th | WR Donovan Peoples-Jones Cle |
| 30 | 358th | CB Jonathan Jones NE |
| 31 | 363rd | CB Carlton Davis TB |
| 32 | 382nd | WR A.J. Green Ari |
| 33 | 387th | WR Cedrick Wilson Mia |