| Week | Add | Drop |
| Week 1 |
Round 1: RB Cordarrelle Patterson - Pit Round 2: CB Cam Taylor-Britt - Cin Round 3: DL Ed Oliver - Buf | |
| Week 2 |
Round 1: WR Devaughn Vele - Den Round 2: LB Henry To'oTo'o - Hou Round 3: TE Zach Ertz - Was |
Round 1: RB Cordarrelle Patterson - Pit Round 2: LB Drue Tranquill - KC Round 3: TE Greg Dulcich - Den |
| Week 3 |
Round 1: LB Dorian Williams - Buf Round 2: DL Tyquan Lewis - Ind |
Round 1: WR Demario Douglas - NE Round 2: LB Ivan Pace - Min |
| Week 4 |
Round 1: WR Demario Douglas - NE Round 3: TE Elijah Higgins - Ari |
Round 1: DL Ed Oliver - Buf Round 3: WR Devaughn Vele - Den |
| 1st Team | 2nd Team |
| Pre-Season | |
| Buffalo Bison | Bernie Kosar |
|
WR
Chris Olave
NO |
RB
Austin Ekeler
Was Rookie Round 3, 3rd Pick (RB Braelon Allen NYJ) Rookie Round 3, 6th Pick (RB Tyrone Tracy Jr. NYG) |
| Pre-Season | |
| Buffalo Bison | Young Gunz II |
|
LB
Roquan Smith
Bal LB Foyesade Oluokun Jac |
Round 3, 1st Pick (WR Mike Williams NYJ) Round 7, 1st Pick (RB Justice Hill Bal) |
| Pre-Season | |
| Buffalo Bison | Bernie Kosar |
|
WR
Diontae Johnson
Car |
Rookie Round 3, 5th Pick (QB J.J. McCarthy Min) |
| Pre-Season | |
| Buffalo Bison | Pimpin Ain't Easy |
|
DL
Aidan Hutchinson
Det |
QB
Dak Prescott
Dal |
| Pre-Season | |
| Buffalo Bison | Young Gunz II |
|
Rookie Round 2, 8th Pick (WR Adonai Mitchell Ind) Round 5, 8th Pick (DL Carl Granderson NO) |
LB
Alex Singleton
Den |
| Pre-Season | |
| Buffalo Bison | Zekeinjunction |
|
Rookie Round 1, 8th Pick (QB Jayden Daniels Was) Round 3, 8th Pick (TE Pat Freiermuth Pit) Round 4, 8th Pick (RB Roschon Johnson Chi) |
S
Kyle Dugger
NE |
| Pre-Season | |
| Buffalo Bison | Foosball Bobbys |
|
Round 2, 8th Pick (DL Danielle Hunter Hou) |
CB
Paulson Adebo
NO |
| Pre-Season | |
| Buffalo Bison | Chicago Blitz |
|
Round 1, 8th Pick (RB Jaleel McLaughlin Den) |
S
Julian Blackmon
Ind |
| Pre-Season | |
| Buffalo Bison | Bernie Kosar |
|
WR
Christian Watson
GB |
Round 6, 6th Pick (LB Ivan Pace Min) |