| Week | Add | Drop |
| 1st Team | 2nd Team |
| Pre-Season | |
| DMo BMo TMo | The Coach |
|
CB
Rasul Douglas
Buf |
Rookie Round 1, 5th Pick |
| Pre-Season | |
| DMo BMo TMo | Joe's Saints |
|
CB
JuJu Brents
Ind |
Rookie Round 1, 9th Pick Round 1, 9th Pick Round 2, 9th Pick Round 3, 9th Pick |
| Pre-Season | |
| DMo BMo TMo | Don Coryell |
|
LB
Denzel Perryman
LAC |
Round 4, 11th Pick |
| Pre-Season | |
| DMo BMo TMo | 2 GAMERS |
|
Round 4, 1st Pick |
Rookie Round 2, 12th Pick |
| Pre-Season | |
| DMo BMo TMo | Don Coryell |
|
Round 3, 1st Pick |
TE
T.J. Hockenson
Min |
| Pre-Season | |
| DMo BMo TMo | 02M LJ |
|
Round 1, 1st Pick Rookie Round 2, 12th Pick Rookie Round 1, 9th Pick |
Rookie Round 1, 2nd Pick |
| Pre-Season | |
| DMo BMo TMo | Bad Reputation |
|
WR
Brandon Aiyuk
SF LB Ernest Jones LAR Rookie Round 2, 9th Pick Round 2, 9th Pick |
Rookie Round 1, 3rd Pick Rookie Round 2, 3rd Pick Round 2, 3rd Pick |
| Pre-Season | |
| DMo BMo TMo | 02M LJ |
|
WR
Jayden Reed
GB Round 7, 1st Pick Round 15, 1st Pick Round 2, 3rd Pick Round 3, 11th Pick |
Round 19, 2nd Pick Rookie Round 1, 12th Pick Rookie Round 1, 9th Pick |
| Pre-Season | |
| DMo BMo TMo | Joe's Saints |
|
WR
George Pickens
Pit Round 2, 1st Pick Round 3, 9th Pick |
WR
D.K. Metcalf
Sea Rookie Round 2, 9th Pick |
| Pre-Season | |
| DMo BMo TMo | Don Coryell |
|
WR
Jaxon Smith-Njigba
Sea Round 8, 1st Pick Round 9, 1st Pick |
Rookie Round 2, 11th Pick Rookie Round 3, 11th Pick Round 3, 11th Pick |
| Pre-Season | |
| DMo BMo TMo | Off Constantly |
|
Round 5, 1st Pick Round 6, 1st Pick Rookie Round 1, 12th Pick Rookie Round 2, 11th Pick Rookie Round 3, 11th Pick Round 4, 11th Pick Round 1, 9th Pick |
Rookie Round 1, 6th Pick Rookie Round 1, 8th Pick |