| Week | Add | Drop |
| Week 1 |
Round 1: PK Cameron Dicker - LAC Round 2: DL Micheal Clemons - NYJ |
Round 1: RB Israel Abanikanda - NYJ Round 2: DL Christian Barmore - NE |
| Week 2 |
Round 1: WR Jauan Jennings - SF Round 2: LB SirVocea Dennis - TB |
Round 1: LB Cody Barton - Den Round 2: WR Darius Slayton - NYG |
| Week 3 |
Round 1: WR Jalen Nailor - Min |
Round 1: WR Malachi Corley - NYJ |
| 1st Team | 2nd Team |
| Pre-Season | |
| Detroit Panthers | The Clown Babies |
|
Rookie Round 1, 9th Pick (RB Jaylen Wright Mia) Rookie Round 2, 9th Pick (WR Roman Wilson Pit) Round 1, 9th Pick (DL Danielle Hunter Hou) Round 2, 9th Pick (WR Tyler Lockett Sea) Round 5, 9th Pick (LB Jordyn Brooks Mia) |
CB
Kenny Moore
Ind |
| Pre-Season | |
| Detroit Panthers | 9 Gamers |
|
Round 4, 9th Pick (LB C.J. Mosley NYJ) |
WR
Jameson Williams
Det |
| Pre-Season | |
| Detroit Panthers | Ecclesiastes |
|
DL
Myles Garrett
Cle WR Jameson Williams Det |
Round 1, 10th Pick (TE Jake Ferguson Dal) |
| Pre-Season | |
| Detroit Panthers | Extreme Bukkake |
|
RB
D'Andre Swift
Chi |
Round 3, 9th Pick |
| Pre-Season | |
| Detroit Panthers | The Clown Babies |
|
QB
Kyler Murray
Ari |
QB
Trevor Lawrence
Jac Round 3, 1st Pick (RB Chuba Hubbard Car) |
| Pre-Season | |
| Detroit Panthers | 9 Gamers |
|
WR
DeAndre Hopkins
Ten |
RB
James Conner
Ari |
| Pre-Season | |
| Detroit Panthers | Extreme Bukkake |
|
Round 3, 9th Pick |
S
Kevin Byard
Chi |