| Week | Add | Drop |
| 1st Team | 2nd Team |
| Pre-Season | |
| Kittle Me This Jimmy G | Hosea |
|
Rookie Round 1, 6th Pick Rookie Round 1, 11th Pick |
WR
Deebo Samuel
SF WR Tee Higgins Cin |
| Pre-Season | |
| Kittle Me This Jimmy G | No Clue |
|
Rookie Round 1, 10th Pick |
RB
Joe Mixon
Hou |
| Pre-Season | |
| Kittle Me This Jimmy G | Hosea |
|
S
Amani Hooker
Ten |
Rookie Round 1, 10th Pick |
| Pre-Season | |
| Kittle Me This Jimmy G | Bad Reputation |
|
Round 19, 6th Pick |
Rookie Round 1, 11th Pick |