| Rank | Player | Position | Proteam | Passing Yards |
| 1. | Deshaun Watson | QB | Hou | 4823 |
| 2. | Patrick Mahomes | QB | KC | 4740 |
| 3. | Tom Brady | QB | TB | 4633 |
| 4. | Matt Ryan | QB | Atl | 4581 |
| 5. | Justin Herbert | QB | LAC | 4579 |
| 6. | Josh Allen | QB | Buf | 4546 |
| 7. | Aaron Rodgers | QB | GB | 4299 |
| 8. | Kirk Cousins | QB | Min | 4265 |
| 9. | Russell Wilson | QB | Sea | 4212 |
| 10. | Philip Rivers | QB | Ind | 4169 |
| 11. | Derek Carr | QB | LV | 4102 |
| 12. | Matthew Stafford | QB | Det | 4084 |
| 13. | Kyler Murray | QB | Ari | 3972 |
| 14. | Jared Goff | QB | LAR | 3951 |
| 15. | Ryan Tannehill | QB | Ten | 3817 |
| 16. | Ben Roethlisberger | QB | Pit | 3804 |
| 17. | Teddy Bridgewater | QB | Car | 3734 |
| 18. | Baker Mayfield | QB | Cle | 3563 |
| 19. | Daniel Jones | QB | NYG | 2943 |
| 20. | Drew Brees | QB | NO | 2942 |
| 21. | Drew Lock | QB | Den | 2933 |
| 22. | Lamar Jackson | QB | Bal | 2757 |
| 23. | Joe Burrow | QB | Cin | 2688 |
| 24. | Cam Newton | QB | NE | 2657 |
| 25. | Carson Wentz | QB | Phi | 2620 |
| 26. | Nick Mullens | QB | SF | 2434 |
| 27. | Gardner Minshew | QB | Jac | 2259 |
| 28. | Sam Darnold | QB | NYJ | 2208 |
| 29. | Andy Dalton | QB | Dal | 2169 |
| 30. | Ryan Fitzpatrick | QB | Mia | 2057 |
| 31. | Mitchell Trubisky | QB | Chi | 2055 |
| 32. | Dak Prescott | QB | Dal | 1856 |
| 33. | Nick Foles | QB | Chi | 1851 |
| 34. | Tua Tagovailoa | QB | Mia | 1814 |
| 35. | Alex Smith | QB | Was | 1582 |
| 36. | Dwayne Haskins | QB | Was | 1439 |
| 37. | Jimmy Garoppolo | QB | SF | 1096 |
| 38. | Mike Glennon | QB | Jac | 1072 |
| 39. | Jalen Hurts | QB | Phi | 991 |
| 40. | Taysom Hill | QB | NO | 928 |
| 41. | Brandon Allen | QB | Cin | 925 |
| 42. | Joe Flacco | QB | NYJ | 864 |
| 43. | C.J. Beathard | QB | SF | 787 |
| 44. | Jake Luton | QB | Jac | 624 |
| 45. | Kyle Allen | QB | Was | 610 |
| 46. | Jeff Driskel | QB | Det | 432 |
| 47. | Colt McCoy | QB | NYG | 375 |
| 48. | P.J. Walker | QB | Car | 368 |
| 49. | Mason Rudolph | QB | Pit | 324 |
| 50. | Brett Rypien | QB | F/A | 295 |