Note: To qualify, non-pitching players must average at least .75 games played per week. This criteria may limit your search results to less than the requested amount (i.e., there may not be enough players at the position requested to fill the amount requested).
| Rank | PPG | Total | Games | Player | Position | Proteam |
| 1. | 29.49 | 383 | 13 | Lamar Jackson | QB | Bal |
| 2. | 26.87 | 322 | 12 | Joe Burrow | QB | Cin |
| 3. | 24.48 | 294 | 12 | Josh Allen | QB | Buf |
| 4. | 24.27 | 291 | 12 | Baker Mayfield | QB | TB |
| 5. | 24.19 | 290 | 12 | Jalen Hurts | QB | Phi |
| 6. | 22.44 | 292 | 13 | Jayden Daniels | QB | Was |
| 7. | 21.40 | 257 | 12 | Sam Darnold | QB | Min |
| 8. | 20.96 | 273 | 13 | Jared Goff | QB | Det |
| 9. | 20.91 | 230 | 11 | Jordan Love | QB | GB |
| 10. | 20.08 | 241 | 12 | Patrick Mahomes | QB | KC |
| 11. | 20.07 | 261 | 13 | Bo Nix | QB | Den |
| 12. | 19.85 | 218 | 11 | Brock Purdy | QB | SF |
| 13. | 19.49 | 234 | 12 | Kyler Murray | QB | Ari |
| 14. | 18.31 | 220 | 12 | Caleb Williams | QB | Chi |
| 15. | 18.20 | 218 | 12 | Geno Smith | QB | Sea |
| 16. | 17.60 | 211 | 12 | Justin Herbert | QB | LAC |
| 17. | 17.47 | 210 | 12 | Aaron Rodgers | QB | NYJ |
| 18. | 17.20 | 206 | 12 | Matthew Stafford | QB | LAR |
| 19. | 16.51 | 215 | 13 | C.J. Stroud | QB | Hou |
| 20. | 16.34 | 196 | 12 | Kirk Cousins | QB | Atl |
| 21. | 13.94 | 153 | 11 | Daniel Jones | QB | NYG |
| 22. | 0.00 | 0 | 11 | Feleipe Franks | QB | Car |