*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 21.00 | Week 07, 2011 | SD | @NYJ@NYJ | 6 Tackles, 3 Assists, 1 TD, 1 FF, 1 Fum Rcvy |
| 2. | 20.00 | Week 04, 2012 | SD | @KC@KC | 4 Tackles, 2 Assists, 0.5 Sack, 1 Int, 1 TD, 1 PD |
| 3. | 15.00 | Week 01, 2013 | SD | HouHou | 9 Tackles, 4 Assists, 0.5 Sack |
| 4. | 13.00 | Week 02, 2015 | SD | @Cin@Cin | 3 Tackles, 4 Assists, 1 FF, 1 Fum Rcvy |
| 4. | 13.00 | Week 04, 2014 | SD | JacJac | 7 Tackles, 3 Assists, 1 Fum Rcvy |
| 6. | 12.00 | Week 14, 2013 | SD | NYGNYG | 3 Tackles, 2 Assists, 1 Int, 2 PD |
| 6. | 12.00 | Week 03, 2012 | SD | AtlAtl | 8 Tackles, 4 Assists |
| 6. | 12.00 | Week 01, 2012 | SD | @Oak@Oak | 7 Tackles, 1 Assist, 1.0 Sack |
| 6. | 12.00 | Week 02, 2011 | SD | @NE@NE | 5 Tackles, 3 Assists, 1.0 Sack |
| 10. | 11.00 | Week 17, 2013 | SD | KCKC | 9 Tackles, 1 Assist, 1 PD |
| 10. | 11.00 | Week 10, 2013 | SD | DenDen | 7 Tackles, 1 Fum Rcvy, 1 PD |
| 10. | 11.00 | Week 11, 2012 | SD | @Den@Den | 7 Tackles, 1 Assist, 1 FF |
| 10. | 11.00 | Week 08, 2012 | SD | @Cle@Cle | 5 Tackles, 6 Assists |
| 14. | 10.00 | Week 07, 2014 | SD | KCKC | 5 Tackles, 5 Assists |
| 14. | 10.00 | Week 06, 2014 | SD | @Oak@Oak | 7 Tackles, 2 Assists, 1 PD |
| 14. | 10.00 | Week 13, 2013 | SD | CinCin | 9 Tackles, 1 Assist |
| 14. | 10.00 | Week 16, 2012 | SD | @NYJ@NYJ | 2 Tackles, 3 Assists, 1.0 Sack, 1 PD |
| 14. | 10.00 | Week 09, 2012 | SD | KCKC | 9 Tackles, 1 PD |
| 14. | 10.00 | Week 17, 2011 | SD | @Oak@Oak | 9 Tackles, 1 Assist |
| 20. | 9.00 | Week 03, 2014 | SD | @Buf@Buf | 4 Tackles, 5 Assists |
| 20. | 9.00 | Week 13, 2011 | SD | @Jac@Jac | 6 Tackles, 2 Assists, 1 PD |
| 20. | 9.00 | Week 05, 2011 | SD | @Den@Den | 4 Tackles, 1 Int |
| 23. | 8.00 | Week 09, 2014 | SD | @Mia@Mia | 6 Tackles, 2 Assists |
| 23. | 8.00 | Week 12, 2013 | SD | @KC@KC | 7 Tackles, 1 PD |
| 23. | 8.00 | Week 05, 2013 | SD | @Oak@Oak | 6 Tackles, 2 Assists |
| 23. | 8.00 | Week 04, 2013 | SD | DalDal | 8 Tackles |
| 23. | 8.00 | Week 10, 2012 | SD | @TB@TB | 3 Tackles, 1 Assist, 1.0 Sack |
| 23. | 8.00 | Week 08, 2011 | SD | @KC@KC | 5 Tackles, 3 Assists |
| 23. | 8.00 | Week 03, 2011 | SD | KCKC | 8 Tackles |
| 30. | 7.00 | Week 11, 2014 | SD | OakOak | 3 Tackles, 1 Fum Rcvy, 1 PD |
| 30. | 7.00 | Week 05, 2014 | SD | NYJNYJ | 3 Tackles, 1.0 Sack |
| 30. | 7.00 | Week 16, 2011 | SD | @Det@Det | 2 Tackles, 1 Assist, 1.0 Sack |
| 30. | 7.00 | Week 15, 2011 | SD | BalBal | 4 Tackles, 1 FF |
| 34. | 6.00 | Week 07, 2015 | SD | OakOak | 5 Tackles, 1 Assist |
| 34. | 6.00 | Week 01, 2015 | SD | DetDet | 4 Tackles, 2 Assists |
| 34. | 6.00 | Week 15, 2013 | SD | @Den@Den | 6 Tackles |
| 34. | 6.00 | Week 12, 2011 | SD | DenDen | 6 Tackles |
| 34. | 6.00 | Week 10, 2011 | SD | OakOak | 6 Tackles |
| 34. | 6.00 | Week 01, 2011 | SD | MinMin | 5 Tackles, 1 Assist |
| 40. | 5.00 | Week 08, 2015 | SD | @Bal@Bal | 1 Tackle, 2 Assists, 0.5 Sack |
| 40. | 5.00 | Week 12, 2014 | SD | StlStl | 2 Tackles, 3 Assists |
| 40. | 5.00 | Week 01, 2014 | SD | @ARI@ARI | 2 Tackles, 1 Fum Rcvy |
| 40. | 5.00 | Week 12, 2012 | SD | BalBal | 3 Tackles, 2 Assists |
| 40. | 5.00 | Week 09, 2011 | SD | GBGB | 4 Tackles, 1 Assist |
| 40. | 5.00 | Week 04, 2011 | SD | MiaMia | 4 Tackles, 1 Assist |
| 46. | 4.00 | Week 15, 2015 | SD | MiaMia | 4 Assists |
| 46. | 4.00 | Week 06, 2015 | SD | @GB@GB | 2 Tackles, 2 Assists |
| 46. | 4.00 | Week 05, 2015 | SD | PitPit | 3 Tackles, 1 Assist |
| 46. | 4.00 | Week 03, 2015 | SD | @Min@Min | 1 Tackle, 3 Assists |
| 46. | 4.00 | Week 14, 2014 | SD | NENE | 1 Tackle, 3 Assists |