*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 26.00 | Week 17, 2013 | SF | @Ari@Ari | 9 Tackles, 1 Assist, 1.0 Sack, 1 Int, 1 FF, 1 Fum Rcvy, 1 PD |
| 2. | 23.00 | Week 16, 2013 | SF | AtlAtl | 9 Tackles, 2 Assists, 1 Int, 1 TD, 1 PD |
| 3. | 18.00 | Week 04, 2013 | SF | @StL@StL | 5 Tackles, 1 Assist, 2.0 Sacks, 1 FF, 1 PD |
| 3. | 18.00 | Week 03, 2012 | SF | @Min@Min | 7 Tackles, 11 Assists |
| 3. | 18.00 | Week 01, 2012 | SF | @GB@GB | 8 Tackles, 3 Assists, 1 Int, 2 PD |
| 6. | 16.00 | Week 05, 2015 | SF | @NYG@NYG | 13 Tackles, 3 Assists |
| 6. | 16.00 | Week 14, 2013 | SF | SeaSea | 8 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 6. | 16.00 | Week 16, 2012 | SF | @Sea@Sea | 4 Tackles, 12 Assists |
| 6. | 16.00 | Week 16, 2011 | SF | @Sea@Sea | 7 Tackles, 5 Assists, 1.0 Sack |
| 6. | 16.00 | Week 10, 2011 | SF | NYGNYG | 12 Tackles, 4 Assists |
| 11. | 15.00 | Week 17, 2017 | Oak | @LAC@LAC | 8 Tackles, 5 Assists, 0.5 Sack |
| 11. | 15.00 | Week 01, 2016 | SF | LALA | 7 Tackles, 2 Assists, 1 Int, 1 PD |
| 11. | 15.00 | Week 06, 2015 | SF | BalBal | 13 Tackles, 2 Assists |
| 11. | 15.00 | Week 13, 2013 | SF | StLStL | 10 Tackles, 1 Assist, 1.0 Sack |
| 11. | 15.00 | Week 11, 2013 | SF | @NO@NO | 13 Tackles, 2 Assists |
| 11. | 15.00 | Week 15, 2012 | SF | @NE@NE | 9 Tackles, 3 Assists, 1 FF |
| 11. | 15.00 | Week 17, 2011 | SF | @StL@StL | 9 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 11. | 15.00 | Week 06, 2011 | SF | @Det@Det | 8 Tackles, 6 Assists, 1 PD |
| 19. | 14.00 | Week 14, 2017 | Oak | @KC@KC | 8 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 19. | 14.00 | Week 13, 2015 | SF | @Chi@Chi | 13 Tackles, 1 Assist |
| 19. | 14.00 | Week 11, 2012 | SF | ChiChi | 13 Tackles, 1 Assist |
| 19. | 14.00 | Week 08, 2011 | SF | CleCle | 11 Tackles, 2 Assists, 1 PD |
| 23. | 13.00 | Week 12, 2017 | Oak | DenDen | 2 Tackles, 5 Assists, 1 Int, 1 PD |
| 23. | 13.00 | Week 08, 2015 | SF | @Stl@Stl | 7 Tackles, 6 Assists |
| 23. | 13.00 | Week 05, 2013 | SF | HouHou | 11 Tackles, 2 Assists |
| 23. | 13.00 | Week 10, 2012 | SF | StLStL | 10 Tackles, 3 Assists |
| 23. | 13.00 | Week 06, 2012 | SF | NYGNYG | 8 Tackles, 5 Assists |
| 23. | 13.00 | Week 09, 2011 | SF | @Was@Was | 7 Tackles, 1 Assist, 1 Fum Rcvy, 2 PD |
| 23. | 13.00 | Week 03, 2011 | SF | @Cin@Cin | 8 Tackles, 5 Assists |
| 30. | 12.00 | Week 13, 2017 | Oak | NYGNYG | 8 Tackles, 1 Assist, 1 Fum Rcvy |
| 30. | 12.00 | Week 04, 2016 | SF | DalDal | 7 Tackles, 1 Assist, 1.0 Sack |
| 30. | 12.00 | Week 02, 2016 | SF | @Car@Car | 4 Tackles, 7 Assists, 1 PD |
| 30. | 12.00 | Week 17, 2015 | SF | StlStl | 9 Tackles, 1 FF |
| 30. | 12.00 | Week 16, 2015 | SF | @Det@Det | 8 Tackles, 2 Assists, 0.5 Sack |
| 30. | 12.00 | Week 15, 2015 | SF | CinCin | 8 Tackles, 4 Assists |
| 30. | 12.00 | Week 09, 2015 | SF | AtlAtl | 6 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 30. | 12.00 | Week 01, 2013 | SF | GBGB | 7 Tackles, 1 Assist, 1 FF, 1 PD |
| 38. | 11.00 | Week 08, 2017 | Oak | @Buf@Buf | 7 Tackles, 4 Assists |
| 38. | 11.00 | Week 07, 2017 | Oak | KCKC | 6 Tackles, 5 Assists |
| 38. | 11.00 | Week 01, 2015 | SF | MinMin | 7 Tackles, 1.0 Sack |
| 38. | 11.00 | Week 08, 2013 | SF | @Jac@Jac | 10 Tackles, 1 PD |
| 38. | 11.00 | Week 03, 2013 | SF | IndInd | 9 Tackles, 2 PD |
| 38. | 11.00 | Week 02, 2013 | SF | @Sea@Sea | 4 Tackles, 7 Assists |
| 38. | 11.00 | Week 07, 2012 | SF | SeaSea | 7 Tackles, 1.0 Sack |
| 38. | 11.00 | Week 02, 2011 | SF | DalDal | 9 Tackles, 1 Assist, 1 PD |
| 46. | 10.00 | Week 09, 2017 | Oak | @Mia@Mia | 5 Tackles, 5 Assists |
| 46. | 10.00 | Week 05, 2017 | SF | @Ind@Ind | 5 Tackles, 5 Assists |
| 46. | 10.00 | Week 02, 2017 | SF | @Sea@Sea | 7 Tackles, 3 Assists |
| 46. | 10.00 | Week 03, 2016 | SF | @Sea@Sea | 6 Tackles, 1 Assist, 1 FF |
| 46. | 10.00 | Week 07, 2015 | SF | SeaSea | 6 Tackles, 4 Assists |