*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 13.00 | Week 03, 2014 | SD | @Buf@Buf | 5 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 1. | 13.00 | Week 16, 2012 | SD | @NYJ@NYJ | 3 Tackles, 2 Assists, 2.0 Sacks |
| 3. | 11.00 | Week 07, 2014 | SD | KCKC | 4 Tackles, 2 Assists, 1.0 Sack, 1 PD |
| 3. | 11.00 | Week 12, 2012 | SD | BalBal | 5 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 3. | 11.00 | Week 08, 2012 | SD | @Cle@Cle | 2 Tackles, 3 Assists, 1.0 Sack, 2 PD |
| 6. | 9.00 | Week 06, 2018 | LAC | @Cle@Cle | 2 Tackles, 1 Assist, 1.5 Sacks |
| 6. | 9.00 | Week 11, 2015 | SD | KCKC | 5 Tackles, 1.0 Sack |
| 6. | 9.00 | Week 06, 2015 | SD | @GB@GB | 4 Tackles, 1 Assist, 1.0 Sack |
| 6. | 9.00 | Week 12, 2014 | SD | StlStl | 2 Tackles, 1.0 Sack, 1 FF |
| 6. | 9.00 | Week 01, 2014 | SD | @ARI@ARI | 4 Tackles, 1 Assist, 1.0 Sack |
| 6. | 9.00 | Week 04, 2013 | SD | DalDal | 3 Tackles, 2 Assists, 1.0 Sack |
| 12. | 8.00 | Week 03, 2017 | LAC | KCKC | 2 Tackles, 1 Assist, 0.5 Sack, 1 FF |
| 12. | 8.00 | Week 16, 2014 | SD | @SF@SF | 2 Tackles, 2 Fum Rcvy |
| 12. | 8.00 | Week 17, 2013 | SD | KCKC | 3 Tackles, 1 Assist, 1.0 Sack |
| 12. | 8.00 | Week 05, 2012 | SD | @NO@NO | 1 Tackle, 1 Assist, 1.0 Sack, 2 PD |
| 16. | 7.00 | Week 14, 2014 | SD | NENE | 4 Tackles, 3 Assists |
| 16. | 7.00 | Week 14, 2012 | SD | @Pit@Pit | 1 Tackle, 1.0 Sack, 2 PD |
| 18. | 6.00 | Week 17, 2019 | Buf | NYJNYJ | 5 Tackles, 1 Assist |
| 18. | 6.00 | Week 12, 2017 | LAC | @Dal@Dal | 1 Tackle, 1 Assist, 1.0 Sack |
| 18. | 6.00 | Week 07, 2015 | SD | OakOak | 6 Tackles |
| 18. | 6.00 | Week 05, 2015 | SD | PitPit | 2 Tackles, 1.0 Sack |
| 18. | 6.00 | Week 17, 2014 | SD | @KC@KC | 2 Tackles, 1.0 Sack |
| 18. | 6.00 | Week 13, 2014 | SD | @Bal@Bal | 5 Tackles, 1 Assist |
| 18. | 6.00 | Week 09, 2014 | SD | @Mia@Mia | 5 Tackles, 1 PD |
| 18. | 6.00 | Week 10, 2012 | SD | @TB@TB | 5 Tackles, 1 Assist |
| 18. | 6.00 | Week 15, 2011 | SD | BalBal | 2 Tackles, 1.0 Sack |
| 27. | 5.00 | Week 10, 2020 | Hou | @CLE@CLE | 1 Tackle, 1.0 Sack |
| 27. | 5.00 | Week 11, 2019 | Buf | @Mia@Mia | 1 Tackle, 1.0 Sack |
| 27. | 5.00 | Week 09, 2018 | LAC | @Sea@Sea | 4 Tackles, 1 Assist |
| 27. | 5.00 | Week 13, 2016 | SD | TBTB | 4 Tackles, 1 Assist |
| 27. | 5.00 | Week 04, 2016 | SD | NONO | 3 Tackles, 2 PD |
| 27. | 5.00 | Week 04, 2015 | SD | CleCle | 3 Tackles, 2 Assists |
| 27. | 5.00 | Week 02, 2015 | SD | @Cin@Cin | 3 Tackles, 2 Assists |
| 27. | 5.00 | Week 15, 2014 | SD | DenDen | 3 Tackles, 2 Assists |
| 27. | 5.00 | Week 14, 2013 | SD | NYGNYG | 2 Tackles, 1 Assist, 0.5 Sack |
| 27. | 5.00 | Week 09, 2013 | SD | @Was@Was | 1 Tackle, 2 Assists, 2 PD |
| 27. | 5.00 | Week 07, 2013 | SD | @Jac@Jac | 1 Tackle, 1.0 Sack |
| 27. | 5.00 | Week 15, 2012 | SD | CarCar | 4 Tackles, 1 Assist |
| 27. | 5.00 | Week 13, 2012 | SD | CinCin | 3 Tackles, 2 Assists |
| 27. | 5.00 | Week 09, 2012 | SD | KCKC | 3 Tackles, 1 Assist, 1 PD |
| 27. | 5.00 | Week 10, 2011 | SD | OakOak | 2 Assists, 1 Fum Rcvy |
| 42. | 4.00 | Week 10, 2018 | LAC | @Oak@Oak | 1 Assist, 1 Fum Rcvy |
| 42. | 4.00 | Week 14, 2017 | LAC | WasWas | 1 Tackle, 1 Assist, 0.5 Sack |
| 42. | 4.00 | Week 05, 2017 | LAC | @NYG@NYG | 1 Tackle, 1 Assist, 2 PD |
| 42. | 4.00 | Week 17, 2016 | SD | KCKC | 3 Tackles, 1 Assist |
| 42. | 4.00 | Week 03, 2016 | SD | @Ind@Ind | 3 Tackles, 1 Assist |
| 42. | 4.00 | Week 02, 2016 | SD | JacJac | 1 Tackle, 1 Fum Rcvy |
| 42. | 4.00 | Week 08, 2014 | SD | @Den@Den | 4 Tackles |
| 42. | 4.00 | Week 05, 2013 | SD | @Oak@Oak | 3 Tackles, 1 Assist |
| 42. | 4.00 | Week 04, 2012 | SD | @KC@KC | 1 Assist, 1 Fum Rcvy |