*=Offensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 38.00 | Week 12, 2016 | SF | @Mia@Mia | 296 Pass, 113 Rush, 3 TD, 1 Int |
| 2. | 36.00 | Week 01, 2013 | SF | GBGB | 412 Pass, 22 Rush, 3 TD |
| 3. | 34.00 | Week 06, 2014 | SF | @Stl@Stl | 343 Pass, 37 Rush, 3 TD |
| 4. | 32.00 | Week 15, 2012 | SF | @NE@NE | 216 Pass, 28 Rush, 4 TD, 1 Int |
| 5. | 31.00 | Week 02, 2015 | SF | @Pit@Pit | 335 Pass, 51 Rush, 2 TD, 1 2-Pt, 1 Fumb |
| 6. | 30.00 | Week 16, 2014 | SF | SDSD | 114 Pass, 151 Rush, 2 TD, 1 Fumb |
| 7. | 29.00 | Week 12, 2013 | SF | @Was@Was | 235 Pass, 20 Rush, 3 TD |
| 7. | 29.00 | Week 08, 2013 | SF | @Jac@Jac | 164 Pass, 54 Rush, 3 TD |
| 9. | 27.00 | Week 16, 2016 | SF | @LA@LA | 266 Pass, 15 Rush, 3 TD, 1 Int |
| 10. | 26.00 | Week 09, 2016 | SF | NONO | 398 Pass, 23 Rush, 2 TD, 1 Int, 1 Fumb |
| 10. | 26.00 | Week 06, 2015 | SF | BalBal | 340 Pass, 10 Rush, 2 TD |
| 10. | 26.00 | Week 17, 2014 | SF | AriAri | 204 Pass, 63 Rush, 2 TD |
| 10. | 26.00 | Week 17, 2013 | SF | @Ari@Ari | 310 Pass, 24 Rush, 2 TD |
| 14. | 25.00 | Week 10, 2016 | SF | @Ari@Ari | 210 Pass, 55 Rush, 2 TD |
| 15. | 24.00 | Week 05, 2015 | SF | @NYG@NYG | 262 Pass, 23 Rush, 2 TD |
| 15. | 24.00 | Week 16, 2013 | SF | AtlAtl | 197 Pass, 51 Rush, 2 TD |
| 15. | 24.00 | Week 15, 2013 | SF | @TB@TB | 203 Pass, 42 Rush, 2 TD |
| 18. | 23.00 | Week 11, 2016 | SF | NENE | 206 Pass, 32 Rush, 2 TD |
| 18. | 23.00 | Week 04, 2014 | SF | PhiPhi | 218 Pass, 58 Rush, 2 TD, 1 Int |
| 18. | 23.00 | Week 17, 2012 | SF | AriAri | 276 Pass, 5 Rush, 2 TD |
| 21. | 22.00 | Week 11, 2012 | SF | ChiChi | 243 Pass, 12 Rush, 2 TD |
| 22. | 21.00 | Week 15, 2016 | SF | @Atl@Atl | 183 Pass, 21 Rush, 2 TD |
| 22. | 21.00 | Week 01, 2014 | SF | @DAL@DAL | 201 Pass, 11 Rush, 2 TD |
| 22. | 21.00 | Week 12, 2012 | SF | @NO@NO | 231 Pass, 27 Rush, 2 TD, 1 Int |
| 25. | 20.00 | Week 03, 2014 | SF | @Ari@Ari | 245 Pass, 54 Rush, 1 TD |
| 25. | 20.00 | Week 06, 2013 | SF | AriAri | 252 Pass, 18 Rush, 2 TD, 1 Int, 1 Fumb |
| 27. | 19.00 | Week 06, 2016 | SF | @Buf@Buf | 187 Pass, 66 Rush, 1 TD |
| 27. | 19.00 | Week 13, 2013 | SF | StLStL | 275 Pass, 21 Rush, 1 TD |
| 27. | 19.00 | Week 07, 2013 | SF | @Ten@Ten | 199 Pass, 68 Rush, 1 TD |
| 30. | 18.00 | Week 04, 2013 | SF | @StL@StL | 167 Pass, 11 Rush, 2 TD, 1 Fumb |
| 30. | 18.00 | Week 14, 2012 | SF | MiaMia | 185 Pass, 53 Rush, 1 TD |
| 32. | 17.00 | Week 11, 2013 | SF | @NO@NO | 127 Pass, 25 Rush, 2 TD, 1 Int |
| 33. | 16.00 | Week 07, 2016 | SF | TBTB | 143 Pass, 84 Rush, 1 TD, 1 Int, 1 Fumb |
| 33. | 16.00 | Week 16, 2012 | SF | @Sea@Sea | 244 Pass, 31 Rush, 1 TD, 1 Int |
| 33. | 16.00 | Week 10, 2012 | SF | StLStL | 117 Pass, 66 Rush, 1 TD |
| 36. | 15.00 | Week 12, 2014 | SF | WasWas | 256 Pass, 14 Rush, 1 TD, 1 Int |
| 36. | 15.00 | Week 11, 2014 | SF | @NYG@NYG | 193 Pass, 24 Rush, 1 TD |
| 36. | 15.00 | Week 10, 2014 | SF | @NO@NO | 210 Pass, 24 Rush, 1 TD, 1 Fumb |
| 36. | 15.00 | Week 07, 2014 | SF | @Den@Den | 263 Pass, 18 Rush, 1 TD, 1 Int |
| 36. | 15.00 | Week 05, 2014 | SF | KCKC | 201 Pass, 18 Rush, 1 TD |
| 36. | 15.00 | Week 13, 2012 | SF | @StL@StL | 208 Pass, 84 Rush, 1 Fumb |
| 42. | 14.00 | Week 17, 2016 | SF | SeaSea | 215 Pass, 16 Rush, 1 TD, 1 Fumb |
| 42. | 14.00 | Week 09, 2014 | SF | StlStl | 237 Pass, 14 Rush, 1 TD, 2 Fumb |
| 42. | 14.00 | Week 02, 2014 | SF | ChiChi | 248 Pass, 66 Rush, 1 TD, 3 Int, 1 Fumb |
| 42. | 14.00 | Week 14, 2013 | SF | SeaSea | 175 Pass, 31 Rush, 1 TD, 1 Int |
| 46. | 13.00 | Week 14, 2016 | SF | NYJNYJ | 133 Pass, 23 Rush, 1 TD |
| 47. | 11.00 | Week 05, 2013 | SF | HouHou | 113 Pass, 14 Rush, 1 TD |
| 47. | 11.00 | Week 04, 2012 | SF | @NYJ@NYJ | 50 Rush, 1 TD |
| 49. | 10.00 | Week 01, 2015 | SF | MinMin | 165 Pass, 41 Rush |
| 49. | 10.00 | Week 14, 2014 | SF | @Oak@Oak | 174 Pass, 26 Rush, 1 TD, 2 Int |