*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 15.00 | Week 16, 2014 | SD | @SF@SF | 8 Tackles, 3 Assists, 1.0 Sack |
| 2. | 13.00 | Week 04, 2015 | SD | CleCle | 13 Tackles |
| 2. | 13.00 | Week 17, 2014 | SD | @KC@KC | 9 Tackles, 4 Assists |
| 4. | 12.00 | Week 17, 2015 | SD | @Den@Den | 7 Tackles, 2 Assists, 1 FF |
| 4. | 12.00 | Week 12, 2015 | SD | @Jac@Jac | 4 Tackles, 2 Assists, 1 Int, 1 PD |
| 6. | 11.00 | Week 02, 2015 | SD | @Cin@Cin | 5 Tackles, 5 Assists, 1 PD |
| 7. | 10.00 | Week 14, 2017 | NO | @Atl@Atl | 8 Tackles, 2 Assists |
| 7. | 10.00 | Week 01, 2016 | SD | @KC@KC | 8 Tackles, 2 Assists |
| 7. | 10.00 | Week 14, 2014 | SD | NENE | 1 Tackle, 2 Assists, 1 Int, 2 PD |
| 7. | 10.00 | Week 03, 2014 | SD | @Buf@Buf | 5 Tackles, 5 Assists |
| 7. | 10.00 | Week 17, 2013 | SD | KCKC | 7 Tackles, 3 Assists |
| 12. | 9.00 | Week 11, 2015 | SD | KCKC | 5 Tackles, 1.0 Sack |
| 12. | 9.00 | Week 09, 2013 | SD | @Was@Was | 4 Tackles, 5 Assists |
| 14. | 8.00 | Week 15, 2017 | NO | NYJNYJ | 5 Tackles, 2 Assists, 1 PD |
| 14. | 8.00 | Week 15, 2015 | SD | MiaMia | 8 Tackles |
| 14. | 8.00 | Week 05, 2015 | SD | PitPit | 5 Tackles, 3 Assists |
| 17. | 7.00 | Week 16, 2017 | NO | AtlAtl | 3 Tackles, 1 Assist, 1 Fum Rcvy |
| 18. | 6.00 | Week 17, 2017 | NO | @TB@TB | 5 Tackles, 1 PD |
| 18. | 6.00 | Week 10, 2017 | NO | @Buf@Buf | 3 Tackles, 3 Assists |
| 18. | 6.00 | Week 01, 2017 | NO | @Min@Min | 4 Tackles, 2 Assists |
| 18. | 6.00 | Week 16, 2015 | SD | @Oak@Oak | 6 Tackles |
| 18. | 6.00 | Week 13, 2015 | SD | DenDen | 4 Tackles, 2 Assists |
| 18. | 6.00 | Week 15, 2014 | SD | DenDen | 5 Tackles, 1 Assist |
| 18. | 6.00 | Week 01, 2014 | SD | @ARI@ARI | 6 Tackles |
| 18. | 6.00 | Week 13, 2013 | SD | CinCin | 3 Tackles, 2 Assists, 1 PD |
| 18. | 6.00 | Week 10, 2013 | SD | DenDen | 3 Tackles, 2 Assists, 1 PD |
| 27. | 5.00 | Week 16, 2019 | NO | @Ten@Ten | 4 Tackles, 1 Assist |
| 27. | 5.00 | Week 17, 2018 | NO | CarCar | 5 Tackles |
| 27. | 5.00 | Week 11, 2017 | NO | WasWas | 3 Tackles, 2 Assists |
| 27. | 5.00 | Week 03, 2017 | NO | @Car@Car | 2 Tackles, 3 Assists |
| 27. | 5.00 | Week 14, 2015 | SD | @KC@KC | 4 Tackles, 1 Assist |
| 27. | 5.00 | Week 03, 2015 | SD | @Min@Min | 3 Tackles, 2 Assists |
| 27. | 5.00 | Week 01, 2015 | SD | DetDet | 3 Tackles, 2 Assists |
| 27. | 5.00 | Week 11, 2013 | SD | @Mia@Mia | 4 Tackles, 1 Assist |
| 27. | 5.00 | Week 06, 2013 | SD | IndInd | 5 Tackles |
| 27. | 5.00 | Week 05, 2013 | SD | @Oak@Oak | 2 Tackles, 3 Assists |
| 37. | 4.00 | Week 02, 2018 | NO | CleCle | 1 Tackle, 3 Assists |
| 37. | 4.00 | Week 01, 2018 | NO | TBTB | 3 Tackles, 1 Assist |
| 37. | 4.00 | Week 08, 2017 | NO | ChiChi | 4 Tackles |
| 37. | 4.00 | Week 02, 2016 | SD | JacJac | 1 Tackle, 3 Assists |
| 37. | 4.00 | Week 13, 2014 | SD | @Bal@Bal | 4 Assists |
| 37. | 4.00 | Week 12, 2014 | SD | StlStl | 2 Tackles, 1 Assist, 1 PD |
| 37. | 4.00 | Week 16, 2013 | SD | OakOak | 2 Tackles, 2 Assists |
| 37. | 4.00 | Week 12, 2013 | SD | @KC@KC | 3 Tackles, 1 PD |
| 37. | 4.00 | Week 07, 2013 | SD | @Jac@Jac | 2 Tackles, 2 Assists |
| 46. | 3.00 | Week 07, 2018 | NO | @Bal@Bal | 3 Tackles |
| 46. | 3.00 | Week 02, 2017 | NO | NENE | 2 Tackles, 1 Assist |
| 46. | 3.00 | Week 03, 2016 | SD | @Ind@Ind | 2 Tackles, 1 Assist |
| 46. | 3.00 | Week 02, 2014 | SD | SeaSea | 1 Tackle, 2 Assists |
| 46. | 3.00 | Week 14, 2013 | SD | NYGNYG | 2 Tackles, 1 PD |