*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 17.00 | Week 14, 2016 | SF | NYJNYJ | 11 Tackles, 2 Assists, 1.0 Sack |
| 2. | 15.00 | Week 10, 2019 | SF | SeaSea | 5 Tackles, 4 Assists, 1 FF, 1 Fum Rcvy |
| 3. | 14.00 | Week 14, 2015 | SF | @Cle@Cle | 7 Tackles, 1 Assist, 1 Int, 1 PD |
| 4. | 13.00 | Week 01, 2017 | SF | CarCar | 7 Tackles, 1 Int, 1 PD |
| 5. | 11.00 | Week 13, 2015 | SF | @Chi@Chi | 5 Tackles, 2 Assists, 1.0 Sack |
| 6. | 10.00 | Week 01, 2020 | SF | AriAri | 3 Tackles, 1 Assist, 1 Int, 1 PD |
| 6. | 10.00 | Week 07, 2015 | SF | SeaSea | 8 Tackles, 2 Assists |
| 8. | 9.00 | Week 06, 2018 | SF | @GB@GB | 7 Tackles, 2 Assists |
| 8. | 9.00 | Week 05, 2017 | SF | @Ind@Ind | 3 Tackles, 4 Assists, 0.5 Sack |
| 8. | 9.00 | Week 08, 2015 | SF | @Stl@Stl | 5 Tackles, 1 Assist, 1 FF |
| 11. | 8.00 | Week 09, 2020 | SF | GBGB | 3 Tackles, 4 Assists, 1 PD |
| 11. | 8.00 | Week 03, 2017 | SF | LARLAR | 6 Tackles, 1 Assist, 1 PD |
| 11. | 8.00 | Week 17, 2016 | SF | SeaSea | 6 Tackles, 1 Assist, 1 PD |
| 11. | 8.00 | Week 15, 2016 | SF | @Atl@Atl | 7 Tackles, 1 Assist |
| 11. | 8.00 | Week 11, 2015 | SF | @Sea@Sea | 4 Tackles, 4 Assists |
| 11. | 8.00 | Week 01, 2015 | SF | MinMin | 4 Tackles, 1.0 Sack |
| 17. | 7.00 | Week 14, 2021 | SF | @CIN@CIN | 3 Tackles, 4 Assists |
| 17. | 7.00 | Week 05, 2021 | SF | @ARI@ARI | 3 Tackles, 4 Assists |
| 17. | 7.00 | Week 02, 2021 | SF | @PHI@PHI | 3 Tackles, 3 Assists, 1 PD |
| 17. | 7.00 | Week 01, 2021 | SF | @DET@DET | 5 Tackles, 2 Assists |
| 17. | 7.00 | Week 05, 2020 | SF | MIAMIA | 5 Tackles, 2 Assists |
| 17. | 7.00 | Week 08, 2018 | SF | @Ari@Ari | 1 Tackle, 1 Int, 1 PD |
| 17. | 7.00 | Week 07, 2018 | SF | LARLAR | 6 Tackles, 1 Assist |
| 17. | 7.00 | Week 01, 2018 | SF | @Min@Min | 5 Tackles, 1 Assist, 1 PD |
| 17. | 7.00 | Week 08, 2017 | SF | @Phi@Phi | 5 Tackles, 2 Assists |
| 17. | 7.00 | Week 04, 2017 | SF | @Ari@Ari | 4 Tackles, 3 Assists |
| 27. | 6.00 | Week 17, 2021 | SF | HOUHOU | 2 Tackles, 4 Assists |
| 27. | 6.00 | Week 16, 2021 | SF | @TEN@TEN | 5 Tackles, 1 Assist |
| 27. | 6.00 | Week 04, 2020 | SF | PHIPHI | 3 Tackles, 2 Assists, 1 PD |
| 27. | 6.00 | Week 12, 2019 | SF | GBGB | 3 Tackles, 1 Assist, 0.5 Sack |
| 27. | 6.00 | Week 11, 2019 | SF | AriAri | 3 Tackles, 1 Fum Rcvy |
| 27. | 6.00 | Week 09, 2019 | SF | @Ari@Ari | 5 Tackles, 1 Assist |
| 27. | 6.00 | Week 12, 2018 | SF | @TB@TB | 3 Tackles, 3 Assists |
| 27. | 6.00 | Week 07, 2017 | SF | DalDal | 5 Tackles, 1 Assist |
| 27. | 6.00 | Week 06, 2017 | SF | @Was@Was | 4 Tackles, 2 Assists |
| 27. | 6.00 | Week 02, 2017 | SF | @Sea@Sea | 2 Tackles, 3 Assists, 1 PD |
| 27. | 6.00 | Week 12, 2015 | SF | AriAri | 5 Tackles, 1 Assist |
| 27. | 6.00 | Week 09, 2015 | SF | AtlAtl | 3 Tackles, 1 Assist, 2 PD |
| 39. | 5.00 | Week 12, 2021 | SF | MINMIN | 5 Tackles |
| 39. | 5.00 | Week 05, 2019 | SF | CleCle | 3 Tackles, 2 Assists |
| 39. | 5.00 | Week 02, 2019 | SF | @Cin@Cin | |
| 39. | 5.00 | Week 01, 2019 | SF | @TB@TB | 3 Tackles, 2 Assists |
| 39. | 5.00 | Week 13, 2018 | SF | @Sea@Sea | 5 Tackles |
| 39. | 5.00 | Week 02, 2018 | SF | DetDet | 3 Tackles, 2 Assists |
| 39. | 5.00 | Week 16, 2016 | SF | @LA@LA | 3 Tackles, 2 Assists |
| 39. | 5.00 | Week 05, 2016 | SF | AriAri | 2 Tackles, 2 Assists, 1 PD |
| 47. | 4.00 | Week 15, 2021 | SF | ATLATL | 3 Tackles, 1 Assist |
| 47. | 4.00 | Week 13, 2021 | SF | @SEA@SEA | 4 Tackles |
| 47. | 4.00 | Week 04, 2021 | SF | SEASEA | 2 Tackles, 2 Assists |
| 47. | 4.00 | Week 03, 2021 | SF | GBGB | 3 Tackles, 1 Assist |