*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 17.00 | Week 13, 2009 | SF | @Sea@Sea | 4 Tackles, 3 Assists, 1.0 Sack, 1 FF, 1 Fum Rcvy |
| 2. | 14.00 | Week 03, 2013 | Buf | @NYJ@NYJ | 11 Tackles, 3 Assists |
| 3. | 13.00 | Week 08, 2008 | SF | SeaSea | 7 Tackles, 2 Assists, 1.0 Sack |
| 4. | 12.00 | Week 17, 2013 | Buf | @NE@NE | 5 Tackles, 1 Assist, 1 Int, 1 PD |
| 4. | 12.00 | Week 11, 2013 | Buf | NYJNYJ | 3 Tackles, 2 Assists, 1.0 Sack, 1 Fum Rcvy |
| 4. | 12.00 | Week 10, 2011 | Cin | PitPit | 4 Tackles, 6 Assists, 0.5 Sack |
| 4. | 12.00 | Week 02, 2007 | SF | @StL@StL | 6 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 8. | 11.00 | Week 08, 2010 | SF | DenDen | 3 Tackles, 1.0 Sack, 1 FF, 1 PD |
| 8. | 11.00 | Week 03, 2009 | SF | @Min@Min | 7 Tackles, 4 Assists |
| 8. | 11.00 | Week 02, 2006 | SF | StLStL | 3 Tackles, 2.0 Sacks |
| 11. | 10.00 | Week 06, 2015 | Buf | CinCin | 5 Tackles, 5 Assists |
| 11. | 10.00 | Week 05, 2013 | Buf | @Cle@Cle | 4 Tackles, 3 Assists, 1 FF |
| 11. | 10.00 | Week 16, 2010 | SF | @StL@StL | 5 Tackles, 2 Assists, 1 Fum Rcvy |
| 11. | 10.00 | Week 12, 2009 | SF | JacJac | 1 Tackle, 1 Assist, 1.0 Sack, 1 FF, 1 PD |
| 11. | 10.00 | Week 12, 2008 | SF | @Dal@Dal | 1 Tackle, 1 Assist, 1.0 Sack, 1 Fum Rcvy, 1 PD |
| 16. | 9.00 | Week 17, 2015 | Buf | NYJNYJ | 2 Tackles, 1 Int, 2 PD |
| 16. | 9.00 | Week 13, 2013 | Buf | AtlAtl | 2 Tackles, 3 Assists, 1.0 Sack |
| 16. | 9.00 | Week 04, 2013 | Buf | BalBal | 5 Tackles, 1.0 Sack |
| 16. | 9.00 | Week 12, 2012 | Cin | OakOak | 1 Tackle, 1 Assist, 1.0 Sack, 1 FF |
| 16. | 9.00 | Week 14, 2011 | Cin | HouHou | 2 Tackles, 3 Assists, 1.0 Sack |
| 16. | 9.00 | Week 05, 2010 | SF | PhiPhi | 2 Tackles, 1.0 Sack, 1 FF |
| 16. | 9.00 | Week 11, 2009 | SF | @GB@GB | 5 Tackles, 1.0 Sack |
| 16. | 9.00 | Week 07, 2009 | SF | @Hou@Hou | 4 Tackles, 1 Assist, 1.0 Sack |
| 16. | 9.00 | Week 12, 2006 | SF | @StL@StL | 3 Tackles, 1 Int1 PD |
| 16. | 9.00 | Week 09, 2006 | SF | MinMin | 5 Tackles, 1 Assist, 1 Fum Rcvy |
| 26. | 8.00 | Week 13, 2015 | Buf | HouHou | 7 Tackles, 1 Assist |
| 26. | 8.00 | Week 04, 2012 | Cin | @Jac@Jac | 4 Tackles, 1.0 Sack |
| 26. | 8.00 | Week 17, 2010 | SF | AriAri | 4 Tackles, 2 Assists, 0.5 Sack |
| 26. | 8.00 | Week 11, 2010 | SF | TBTB | 6 Tackles, 2 Assists |
| 26. | 8.00 | Week 06, 2010 | SF | OakOak | 2 Tackles, 1 Int, 1 PD |
| 26. | 8.00 | Week 16, 2009 | SF | DetDet | 7 Tackles, 1 PD |
| 32. | 7.00 | Week 11, 2015 | Buf | @NE@NE | 2 Tackles, 1 Assist, 1.0 Sack |
| 32. | 7.00 | Week 15, 2013 | Buf | @Jac@Jac | 3 Tackles, 1.0 Sack |
| 32. | 7.00 | Week 14, 2010 | SF | SeaSea | 4 Tackles, 2 Assists, 1 PD |
| 32. | 7.00 | Week 05, 2009 | SF | AtlAtl | 4 Tackles, 1 FF |
| 32. | 7.00 | Week 04, 2009 | SF | StLStL | 3 Tackles, 2 Assists, 0.5 Sack |
| 32. | 7.00 | Week 11, 2008 | SF | StLStL | 3 Tackles, 1.0 Sack |
| 32. | 7.00 | Week 07, 2008 | SF | @NYG@NYG | 2 Tackles, 2 Assists, 1 FF |
| 32. | 7.00 | Week 08, 2006 | SF | @Chi@Chi | 6 Tackles, 1 Assist |
| 40. | 6.00 | Week 14, 2013 | Buf | @TB@TB | 5 Tackles, 1 Assist |
| 40. | 6.00 | Week 01, 2012 | Cin | @Bal@Bal | 6 Tackles |
| 40. | 6.00 | Week 13, 2011 | Cin | @Pit@Pit | 3 Tackles, 3 Assists |
| 40. | 6.00 | Week 11, 2011 | Cin | @Bal@Bal | 5 Tackles, 1 Assist |
| 40. | 6.00 | Week 03, 2010 | SF | @KC@KC | 6 Tackles |
| 40. | 6.00 | Week 02, 2010 | SF | NONO | 4 Tackles, 1 Assist, 1 PD |
| 40. | 6.00 | Week 09, 2009 | SF | TenTen | 2 Tackles, 1.0 Sack |
| 40. | 6.00 | Week 16, 2008 | SF | @StL@StL | 6 Tackles |
| 40. | 6.00 | Week 15, 2006 | SF | @Sea@Sea | 2 Tackles, 1.0 Sack |
| 40. | 6.00 | Week 01, 2006 | SF | @Ari@Ari | 6 Tackles |
| 50. | 5.00 | Week 15, 2015 | Buf | @Was@Was | 2 Tackles, 1 Assist, 2 PD |