*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 22.00 | Week 13, 2017 | Bal | DetDet | 2 Tackles, 1 Assist, 1.0 Sack, 1 Int, 1 TD, 1 FF, 1 PD |
| 2. | 21.00 | Week 14, 2016 | Bal | @NE@NE | 6 Tackles, 5 Assists, 1.0 Sack, 1 Int, 1 PD |
| 3. | 19.00 | Week 08, 2011 | SD | @KC@KC | 7 Tackles, 2 Int, 2 PD |
| 3. | 19.00 | Week 03, 2009 | SD | MiaMia | 6 Tackles, 1 Assist, 1 Int, 1 TD, 1 PD |
| 3. | 19.00 | Week 13, 2008 | SD | AtlAtl | 7 Tackles, 3 Assists, 1 TD, 1 Fum Rcvy |
| 6. | 18.00 | Week 11, 2012 | SD | @Den@Den | 5 Tackles, 1 Assist, 1 Int, 1 TD, 1 PD |
| 7. | 17.00 | Week 04, 2019 | LAR | TBTB | 10 Tackles, 5 Assists, 2 PD |
| 7. | 17.00 | Week 13, 2013 | SD | CinCin | 7 Tackles, 1 Assist, 1 Int, 1 Fum Rcvy, 1 PD |
| 7. | 17.00 | Week 16, 2010 | SD | @Cin@Cin | 11 Tackles, 5 Assists, 1 PD |
| 7. | 17.00 | Week 12, 2010 | SD | @Ind@Ind | 4 Tackles, 1 Int, 1 TD, 2 PD |
| 11. | 16.00 | Week 09, 2015 | SD | ChiChi | 9 Tackles, 4 Assists, 1 Fum Rcvy |
| 11. | 16.00 | Week 07, 2014 | SD | KCKC | 12 Tackles, 4 Assists |
| 11. | 16.00 | Week 17, 2013 | SD | KCKC | 9 Tackles, 7 Assists |
| 14. | 15.00 | Week 04, 2017 | Bal | PitPit | 4 Tackles, 4 Assists, 1 Int, 2 PD |
| 14. | 15.00 | Week 09, 2013 | SD | @Was@Was | 9 Tackles, 6 Assists |
| 16. | 14.00 | Week 04, 2015 | SD | CleCle | 8 Tackles, 4 Assists, 0.5 Sack |
| 16. | 14.00 | Week 08, 2014 | SD | @Den@Den | 9 Tackles, 2 Assists, 1 FF |
| 16. | 14.00 | Week 01, 2013 | SD | HouHou | 11 Tackles, 2 Assists, 1 PD |
| 16. | 14.00 | Week 05, 2012 | SD | @NO@NO | 6 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 16. | 14.00 | Week 04, 2011 | SD | MiaMia | 6 Tackles, 2 Assists, 1 Int, 1 PD |
| 21. | 13.00 | Week 01, 2015 | SD | DetDet | 11 Tackles, 2 PD |
| 21. | 13.00 | Week 16, 2014 | SD | @SF@SF | 8 Tackles, 2 Assists, 1 FF |
| 21. | 13.00 | Week 08, 2012 | SD | @Cle@Cle | 5 Tackles, 1 Assist, 1 FF, 1 Fum Rcvy, 1 PD |
| 21. | 13.00 | Week 06, 2010 | SD | @StL@StL | 11 Tackles, 1 Assist, 1 PD |
| 21. | 13.00 | Week 03, 2008 | SD | NYJNYJ | 5 Tackles, 2 Assists, 1 Int, 1 PD |
| 26. | 12.00 | Week 05, 2018 | Bal | @Cle@Cle | 7 Tackles, 1 Assist, 1.0 Sack |
| 26. | 12.00 | Week 02, 2016 | Bal | @Cle@Cle | 5 Tackles, 1 Assist, 1 Int, 1 PD |
| 26. | 12.00 | Week 12, 2013 | SD | @KC@KC | 6 Tackles, 1 FF, 1 Fum Rcvy |
| 26. | 12.00 | Week 11, 2013 | SD | @Mia@Mia | 7 Tackles, 1.0 Sack, 1 PD |
| 26. | 12.00 | Week 07, 2011 | SD | @NYJ@NYJ | 5 Tackles, 1 Assist, 1 Int, 1 PD |
| 26. | 12.00 | Week 02, 2011 | SD | @NE@NE | 8 Tackles, 4 Assists |
| 26. | 12.00 | Week 17, 2010 | SD | @Den@Den | 5 Tackles, 1 Assist, 1 Int, 1 PD |
| 26. | 12.00 | Week 08, 2010 | SD | TenTen | 10 Tackles, 1 Assist, 1 PD |
| 26. | 12.00 | Week 17, 2008 | SD | DenDen | 10 Tackles, 1 Assist, 1 PD |
| 26. | 12.00 | Week 01, 2008 | SD | CarCar | 7 Tackles, 4 Assists, 1 PD |
| 36. | 11.00 | Week 03, 2014 | SD | @Buf@Buf | 9 Tackles, 1 Assist, 1 PD |
| 36. | 11.00 | Week 04, 2012 | SD | @KC@KC | 3 Tackles, 2 Assists, 1 Int, 1 PD |
| 36. | 11.00 | Week 16, 2009 | SD | @Ten@Ten | 4 Tackles, 1 Int, 2 PD |
| 36. | 11.00 | Week 16, 2008 | SD | @TB@TB | 9 Tackles, 1 Assist, 1 PD |
| 36. | 11.00 | Week 11, 2008 | SD | @Pit@Pit | 7 Tackles, 4 Assists |
| 36. | 11.00 | Week 06, 2008 | SD | NENE | 11 Tackles |
| 36. | 11.00 | Week 08, 2007 | SD | HouHou | 4 Tackles, 1 Assist, 1 Int, 1 PD |
| 43. | 10.00 | Week 12, 2019 | LAR | BalBal | 8 Tackles, 1 Assist, 1 PD |
| 43. | 10.00 | Week 06, 2019 | LAR | SFSF | 4 Tackles, 6 Assists |
| 43. | 10.00 | Week 11, 2017 | Bal | @GB@GB | 4 Tackles, 1 Int, 1 PD |
| 43. | 10.00 | Week 09, 2017 | Bal | @Ten@Ten | 4 Tackles, 1 Int, 1 PD |
| 43. | 10.00 | Week 02, 2017 | Bal | CleCle | 4 Tackles, 1 Int, 1 PD |
| 43. | 10.00 | Week 13, 2016 | Bal | MiaMia | 2 Tackles, 1 Assist, 1 Int, 2 PD |
| 43. | 10.00 | Week 10, 2016 | Bal | CleCle | 4 Tackles, 1 Int, 1 PD |
| 43. | 10.00 | Week 07, 2016 | Bal | @NYJ@NYJ | 3 Tackles, 7 Assists |