*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 23.00 | Week 07, 2020 | Buf | @NYJ@NYJ | 5 Tackles, 1 Assist, 2.0 Sacks, 1 Int, 1 FF, 1 PD |
| 2. | 20.00 | Week 01, 2022 | Hou | INDIND | 3 Tackles, 2.0 Sacks, 1 Int, 1 FF, 1 PD |
| 3. | 17.00 | Week 09, 2015 | Buf | MiaMia | 3 Tackles, 2.0 Sacks, 1 FF, 1 Fum Rcvy |
| 4. | 16.00 | Week 05, 2014 | Buf | @Det@Det | 4 Tackles, 1 Assist, 2.0 Sacks, 1 FF |
| 5. | 15.00 | Week 13, 2014 | Buf | CleCle | 1 Tackle, 2 Assists, 1 TD, 1 FF, 1 Fum Rcvy |
| 6. | 14.00 | Week 02, 2017 | Buf | @Car@Car | 4 Tackles, 2 Assists, 2.0 Sacks |
| 6. | 14.00 | Week 01, 2016 | Buf | @Bal@Bal | 5 Tackles, 1 Assist, 2.0 Sacks |
| 6. | 14.00 | Week 06, 2013 | Buf | CinCin | 5 Tackles, 8 Assists, 1 PD |
| 6. | 14.00 | Week 05, 2013 | Buf | @Cle@Cle | 2 Tackles, 3 Assists, 1.5 Sacks, 1 FF |
| 10. | 13.00 | Week 09, 2022 | Hou | PhiPhi | 4 Tackles, 1 Assist, 2.0 Sacks |
| 10. | 13.00 | Week 12, 2014 | Buf | NYJNYJ | 4 Tackles, 1 Assist, 2.0 Sacks |
| 12. | 12.00 | Week 03, 2022 | Hou | @Chi@Chi | 3 Tackles, 1 Assist, 2.0 Sacks |
| 12. | 12.00 | Week 06, 2018 | Buf | @Hou@Hou | 1 Tackle, 2 Assists, 1.5 Sacks, 1 FF |
| 12. | 12.00 | Week 10, 2014 | Buf | KCKC | 3 Tackles, 1 Assist, 2.0 Sacks |
| 12. | 12.00 | Week 10, 2013 | Buf | @Pit@Pit | 4 Tackles, 2.0 Sacks |
| 12. | 12.00 | Week 06, 2012 | Ind | @NYJ@NYJ | 3 Tackles, 5 Assists, 1.0 Sack |
| 17. | 11.00 | Week 01, 2019 | Buf | @NYJ@NYJ | 1 Tackle, 2 Assists, 1.5 Sacks, 2 PD |
| 17. | 11.00 | Week 05, 2018 | Buf | TenTen | 4 Tackles, 1.0 Sack, 1 FF |
| 17. | 11.00 | Week 15, 2015 | Buf | @Was@Was | 4 Tackles, 3 Assists, 1.0 Sack |
| 17. | 11.00 | Week 02, 2015 | Buf | NENE | 2 Tackles, 1 Assist, 1.0 Sack, 1 FF, 1 PD |
| 17. | 11.00 | Week 07, 2014 | Buf | MinMin | 3 Tackles, 2 Assists, 1.5 Sacks |
| 17. | 11.00 | Week 06, 2014 | Buf | NENE | 5 Tackles, 2 Assists, 1.0 Sack |
| 23. | 10.00 | Week 02, 2018 | Buf | LACLAC | 5 Tackles, 1 Assist, 1.0 Sack |
| 23. | 10.00 | Week 04, 2017 | Buf | @Atl@Atl | 3 Tackles, 1.0 Sack, 1 FF |
| 23. | 10.00 | Week 13, 2015 | Buf | HouHou | 4 Tackles, 2 Assists, 1.0 Sack |
| 23. | 10.00 | Week 13, 2013 | Buf | AtlAtl | 2 Tackles, 2.0 Sacks |
| 27. | 9.00 | Week 16, 2023 | Hou | CleCle | |
| 27. | 9.00 | Week 15, 2020 | Buf | @DEN@DEN | 1 TD, 1 Fum Rcvy |
| 27. | 9.00 | Week 10, 2018 | Buf | @NYJ@NYJ | 2 Tackles, 2 Assists, 1.0 Sack, 1 PD |
| 27. | 9.00 | Week 02, 2014 | Buf | MiaMia | 3 Tackles, 2 Assists, 1.0 Sack |
| 31. | 8.00 | Week 17, 2023 | Hou | TenTen | 1 Tackle, 1.0 Sack, 1 FF |
| 31. | 8.00 | Week 17, 2022 | Hou | JacJac | 2 Tackles, 2 Assists, 1.0 Sack |
| 31. | 8.00 | Week 10, 2022 | Hou | @NYG@NYG | 4 Tackles, 1.0 Sack |
| 31. | 8.00 | Week 08, 2021 | Buf | MIAMIA | 1 Tackle, 1.0 Sack, 1 FF |
| 31. | 8.00 | Week 09, 2020 | Buf | SEASEA | 1 Tackle, 1.0 Sack, 1 FF |
| 31. | 8.00 | Week 03, 2018 | Buf | @Min@Min | 1 Tackle, 1.0 Sack, 1 FF |
| 31. | 8.00 | Week 15, 2013 | Buf | @Jac@Jac | 3 Tackles, 1.0 Sack, 1 PD |
| 31. | 8.00 | Week 09, 2013 | Buf | KCKC | 1 Tackle, 1.0 Sack, 1 FF |
| 39. | 7.00 | Week 04, 2023 | Hou | PitPit | 2 Tackles, 1 Assist, 1.0 Sack |
| 39. | 7.00 | Week 08, 2020 | Buf | NENE | 2 Tackles, 1 Assist, 1.0 Sack |
| 39. | 7.00 | Week 09, 2019 | Buf | WasWas | 2 Tackles, 1 Assist, 1.0 Sack |
| 39. | 7.00 | Week 15, 2016 | Buf | CleCle | 3 Tackles, 1.0 Sack |
| 39. | 7.00 | Week 09, 2016 | Buf | @Sea@Sea | 3 Tackles, 1.0 Sack |
| 39. | 7.00 | Week 05, 2016 | Buf | @LA@LA | 2 Tackles, 2 Assists, 1 FF |
| 39. | 7.00 | Week 04, 2016 | Buf | @NE@NE | 2 Tackles, 1 Assist, 1.0 Sack |
| 39. | 7.00 | Week 03, 2016 | Buf | AriAri | 2 Tackles, 1.0 Sack, 1 PD |
| 47. | 6.00 | Week 08, 2022 | Hou | TenTen | 2 Tackles, 1.0 Sack |
| 47. | 6.00 | Week 12, 2020 | Buf | LACLAC | 1 Tackle, 3 Assists, 0.5 Sack |
| 47. | 6.00 | Week 14, 2019 | Buf | BalBal | 2 Tackles, 1.0 Sack |
| 47. | 6.00 | Week 11, 2014 | Buf | @Mia@Mia | 3 Tackles, 1 FF |