*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 35.00 | Week 11, 2012 * | SF | ChiChi | 6 Tackles, 1 Assist, 5.5 Sacks, 2 FF |
| 2. | 17.00 | Week 03, 2020 | Dal | @Sea@Sea | 4 Tackles, 3.0 Sacks, 1 PD |
| 3. | 15.00 | Week 01, 2020 | Dal | @LAR@LAR | 6 Tackles, 5 Assists, 1.0 Sack |
| 3. | 15.00 | Week 02, 2013 | SF | @Sea@Sea | 6 Tackles, 1 Assist, 2.0 Sacks |
| 3. | 15.00 | Week 04, 2012 | SF | @NYJ@NYJ | 3 Tackles, 1 Assist, 2.0 Sacks, 1 FF |
| 6. | 14.00 | Week 14, 2012 | SF | MiaMia | 5 Tackles, 1 Assist, 2.0 Sacks |
| 6. | 14.00 | Week 10, 2012 | SF | StLStL | 6 Tackles, 2.0 Sacks |
| 6. | 14.00 | Week 08, 2012 | SF | @Ari@Ari | 6 Tackles, 2.0 Sacks |
| 9. | 12.00 | Week 14, 2020 | Dal | @CIN@CIN | 1 Tackle, 2 Assists, 1 Fum Rcvy |
| 9. | 12.00 | Week 15, 2013 | SF | @TB@TB | 4 Tackles, 2.0 Sacks |
| 11. | 11.00 | Week 12, 2014 | SF | WasWas | 3 Tackles, 2.0 Sacks |
| 11. | 11.00 | Week 12, 2013 | SF | @Was@Was | 2 Tackles, 1 Assist, 2.0 Sacks |
| 11. | 11.00 | Week 01, 2013 | SF | GBGB | 2 Tackles, 3 Assists, 1.5 Sacks |
| 11. | 11.00 | Week 12, 2012 | SF | @NO@NO | 4 Tackles, 1 Assist, 1.5 Sacks |
| 11. | 11.00 | Week 04, 2011 | SF | @Phi@Phi | 4 Tackles, 1 Assist, 1.5 Sacks |
| 16. | 10.00 | Week 03, 2013 | SF | IndInd | 6 Tackles, 1.0 Sack |
| 17. | 9.00 | Week 02, 2012 | SF | DetDet | 4 Tackles, 1 Assist, 1.0 Sack |
| 18. | 8.00 | Week 07, 2012 | SF | SeaSea | 3 Tackles, 1 Assist, 1.0 Sack |
| 19. | 7.00 | Week 08, 2020 | Dal | @PHI@PHI | 2 Tackles, 1 Assist, 1.0 Sack |
| 19. | 7.00 | Week 10, 2015 | Oak | MinMin | 3 Tackles, 1.0 Sack |
| 19. | 7.00 | Week 09, 2015 | Oak | @Pit@Pit | 3 Tackles, 1.0 Sack |
| 19. | 7.00 | Week 15, 2012 | SF | @NE@NE | 1 Assist, 1 PD |
| 19. | 7.00 | Week 13, 2012 | SF | @StL@StL | 2 Tackles, 1 Assist, 1.0 Sack |
| 19. | 7.00 | Week 01, 2012 | SF | @GB@GB | 2 Tackles, 1 Assist, 1.0 Sack |
| 25. | 6.00 | Week 16, 2012 | SF | @Sea@Sea | 1 Tackle, 5 Assists |
| 26. | 5.00 | Week 02, 2020 | Dal | AtlAtl | 2 Tackles, 3 Assists |
| 26. | 5.00 | Week 15, 2014 | SF | @Sea@Sea | 3 Tackles, 2 Assists |
| 28. | 4.00 | Week 12, 2020 | Dal | WASWAS | 2 Tackles, 2 Assists |
| 28. | 4.00 | Week 06, 2020 | Dal | ARIARI | 2 Tackles, 1 Assist, 1 PD |
| 28. | 4.00 | Week 05, 2020 | Dal | NYGNYG | 3 Tackles, 1 Assist |
| 28. | 4.00 | Week 08, 2015 | Oak | NYJNYJ | 3 Tackles, 1 Assist |
| 28. | 4.00 | Week 17, 2013 | SF | @Ari@Ari | 4 Tackles |
| 33. | 3.00 | Week 15, 2020 | Dal | SFSF | 1 Fum Rcvy |
| 33. | 3.00 | Week 11, 2020 | Dal | @MIN@MIN | 3 Tackles |
| 33. | 3.00 | Week 07, 2020 | Dal | @WAS@WAS | 1 Tackle, 2 Assists |
| 33. | 3.00 | Week 03, 2012 | SF | @Min@Min | 3 Tackles |
| 37. | 2.00 | Week 09, 2020 | Dal | PITPIT | 2 Tackles |
| 37. | 2.00 | Week 04, 2020 | Dal | CLECLE | 2 Tackles |
| 37. | 2.00 | Week 17, 2014 | SF | AriAri | 1 Tackle, 1 Assist |
| 37. | 2.00 | Week 13, 2014 | SF | SeaSea | 2 Assists |
| 37. | 2.00 | Week 13, 2013 | SF | StLStL | 2 Tackles |
| 37. | 2.00 | Week 17, 2012 | SF | AriAri | 2 Tackles |
| 37. | 2.00 | Week 06, 2012 | SF | NYGNYG | 1 Tackle, 1 Assist |
| 37. | 2.00 | Week 06, 2011 | SF | @Det@Det | 1 Safety |
| 45. | 1.00 | Week 16, 2020 | Dal | PHIPHI | 1 Tackle |
| 45. | 1.00 | Week 13, 2020 | Dal | @BAL@BAL | 1 Assist |
| 45. | 1.00 | Week 16, 2014 | SF | SDSD | 1 Tackle |
| 45. | 1.00 | Week 16, 2013 | SF | AtlAtl | 1 Tackle |
| 45. | 1.00 | Week 14, 2013 | SF | SeaSea | 1 Tackle |
| 45. | 1.00 | Week 11, 2013 | SF | @NO@NO | 1 Tackle |