*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 23.00 | Week 13, 2014 | StL | OakOak | 5 Tackles, 3.0 Sacks, 2 FF |
| 2. | 22.00 | Week 11, 2021 | Chi | BALBAL | 4 Tackles, 1 Assist, 3.5 Sacks, 1 FF |
| 2. | 22.00 | Week 05, 2012 * | StL | AriAri | 4 Tackles, 2 Assists, 3.0 Sacks, 1 FF, 1 PD |
| 4. | 21.00 | Week 12, 2013 | StL | ChiChi | 4 Tackles, 1.0 Sack, 1 TD, 1 FF, 1 Fum Rcvy, 1 PD |
| 4. | 21.00 | Week 01, 2013 | StL | AriAri | 3 Tackles, 3.0 Sacks, 2 FF |
| 6. | 19.00 | Week 15, 2013 | StL | NONO | 5 Tackles, 2.0 Sacks, 1 FF, 1 Fum Rcvy |
| 7. | 18.00 | Week 16, 2013 | StL | TBTB | 6 Tackles, 3.0 Sacks |
| 8. | 17.00 | Week 08, 2013 | StL | SeaSea | 5 Tackles, 3.0 Sacks |
| 9. | 16.00 | Week 09, 2014 | StL | @SF@SF | 4 Tackles, 2.0 Sacks, 1 FF, 1 PD |
| 9. | 16.00 | Week 08, 2014 | StL | @KC@KC | 5 Tackles, 2.0 Sacks, 1 FF |
| 11. | 15.00 | Week 15, 2021 | Chi | MINMIN | 2 Tackles, 2 Assists, 2.0 Sacks, 1 FF |
| 11. | 15.00 | Week 14, 2014 | StL | @Was@Was | 3 Tackles, 2 Assists, 1.5 Sacks, 1 FF, 1 PD |
| 11. | 15.00 | Week 10, 2013 | StL | @Ind@Ind | 3 Tackles, 1 Assist, 2.0 Sacks, 1 FF |
| 14. | 13.00 | Week 16, 2019 | Dal | @Phi@Phi | 5 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 14. | 13.00 | Week 15, 2017 | LAR | @Sea@Sea | 2 Tackles, 2.0 Sacks, 1 FF |
| 14. | 13.00 | Week 05, 2015 | StL | @GB@GB | 4 Tackles, 2 Assists, 1.0 Sack, 1 FF |
| 14. | 13.00 | Week 01, 2015 | StL | SeaSea | 3 Tackles, 2 Assists, 2.0 Sacks |
| 18. | 12.00 | Week 04, 2021 | Chi | DETDET | 5 Tackles, 1.0 Sack, 1 FF |
| 18. | 12.00 | Week 04, 2019 | Dal | @NO@NO | 3 Tackles, 2.0 Sacks, 1 PD |
| 18. | 12.00 | Week 12, 2017 | LAR | NONO | 3 Tackles, 2 Assists, 1.0 Sack, 1 FF |
| 21. | 10.00 | Week 14, 2021 | Chi | @GB@GB | 2 Tackles, 2.0 Sacks |
| 21. | 10.00 | Week 06, 2019 | Dal | @NYJ@NYJ | 2 Tackles, 2.0 Sacks |
| 21. | 10.00 | Week 03, 2016 | LA | @TB@TB | 3 Tackles, 1.0 Sack, 1 FF |
| 21. | 10.00 | Week 10, 2012 | StL | @SF@SF | 3 Tackles, 1 Assist, 1.5 Sacks |
| 25. | 9.00 | Week 12, 2021 | Chi | @DET@DET | 4 Tackles, 1 Assist, 1.0 Sack |
| 25. | 9.00 | Week 15, 2020 | Chi | @MIN@MIN | 1 Tackle, 1 Assist, 1.0 Sack, 1 FF |
| 25. | 9.00 | Week 13, 2018 | Mia | BufBuf | 2 Tackles, 1.0 Sack, 1 FF |
| 25. | 9.00 | Week 10, 2018 | Mia | @GB@GB | 2 Tackles, 1 Assist, 1.5 Sacks |
| 25. | 9.00 | Week 03, 2015 | StL | PitPit | 1 Tackle, 1.0 Sack, 1 FF, 1 PD |
| 25. | 9.00 | Week 17, 2013 | StL | @Sea@Sea | 2 Tackles, 3 Assists, 1.0 Sack |
| 25. | 9.00 | Week 11, 2011 | StL | SeaSea | 5 Tackles, 1.0 Sack |
| 32. | 8.00 | Week 17, 2021 | Chi | NYGNYG | 1 Tackle, 1.0 Sack, 1 FF |
| 32. | 8.00 | Week 09, 2021 | Chi | @PIT@PIT | 4 Tackles, 1.0 Sack |
| 32. | 8.00 | Week 06, 2021 | Chi | GBGB | 3 Tackles, 1 Assist, 1.0 Sack |
| 32. | 8.00 | Week 03, 2021 | Chi | @CLE@CLE | 1 Tackle, 1 Assist, 1.5 Sacks |
| 32. | 8.00 | Week 02, 2020 | Chi | NYGNYG | 1 Tackle, 1.0 Sack, 1 FF |
| 32. | 8.00 | Week 12, 2019 | Dal | @NE@NE | 1 Tackle, 1.0 Sack, 1 FF |
| 32. | 8.00 | Week 08, 2015 | StL | SFSF | 3 Tackles, 1.0 Sack, 1 PD |
| 32. | 8.00 | Week 10, 2014 | StL | @Ari@Ari | 2 Tackles, 2 Assists, 1.0 Sack |
| 32. | 8.00 | Week 07, 2014 | StL | SeaSea | 3 Tackles, 1 Assist, 1.0 Sack |
| 32. | 8.00 | Week 06, 2013 | StL | @Hou@Hou | 1 Tackle, 1.0 Sack, 1 FF |
| 32. | 8.00 | Week 02, 2013 | StL | @Atl@Atl | 4 Tackles, 1.0 Sack |
| 43. | 7.00 | Week 02, 2021 | Chi | CINCIN | 3 Tackles, 1.0 Sack |
| 43. | 7.00 | Week 17, 2019 | Dal | WasWas | 2 Tackles, 1 Assist, 1.0 Sack |
| 43. | 7.00 | Week 11, 2019 | Dal | @Det@Det | 3 Tackles, 1.0 Sack |
| 43. | 7.00 | Week 10, 2019 | Dal | MinMin | 1 Tackle, 2 Assists, 1.0 Sack |
| 43. | 7.00 | Week 07, 2019 | Dal | PhiPhi | 1 Tackle, 1 Assist, 1.0 Sack, 1 PD |
| 43. | 7.00 | Week 03, 2019 | Dal | MiaMia | 3 Tackles, 1.0 Sack |
| 43. | 7.00 | Week 16, 2018 | Mia | JacJac | 2 Tackles, 1 Assist, 1.0 Sack |
| 43. | 7.00 | Week 14, 2018 | Mia | NENE | 1 Tackle, 2 Assists, 1.0 Sack |