*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 19.00 | Week 04, 2022 | Buf | @Bal@Bal | 4 Tackles, 2 Assists, 2 Int, 3 PD |
| 1. | 19.00 | Week 03, 2019 | Buf | CinCin | 12 Tackles, 1 Assist, 1 FF, 1 Fum Rcvy |
| 3. | 18.00 | Week 16, 2017 | Buf | @NE@NE | 2 Tackles, 4 Assists, 1 Int, 1 TD, 1 PD |
| 3. | 18.00 | Week 02, 2017 | Buf | @Car@Car | 7 Tackles, 4 Assists, 1.0 Sack, 3 PD |
| 5. | 17.00 | Week 07, 2023 | Buf | @NE@NE | 5 Tackles, 5 Assists, 1.0 Sack, 1 FF |
| 5. | 17.00 | Week 10, 2021 | Buf | @NYJ@NYJ | 4 Tackles, 6 Assists, 1 Int, 2 PD |
| 5. | 17.00 | Week 08, 2021 | Buf | MIAMIA | 11 Tackles, 1 Int, 1 PD |
| 5. | 17.00 | Week 16, 2018 | Buf | @NE@NE | 4 Tackles, 3 Assists, 1.0 Sack, 1 Int, 1 PD |
| 9. | 16.00 | Week 09, 2020 | Buf | SEASEA | 7 Tackles, 3 Assists, 1 Int, 1 PD |
| 9. | 16.00 | Week 12, 2018 | Buf | JacJac | 9 Tackles, 1 Assist, 1 Int, 1 PD |
| 11. | 14.00 | Week 14, 2020 | Buf | PITPIT | 7 Tackles, 3 Assists, 1 FF, 1 PD |
| 11. | 14.00 | Week 03, 2020 | Buf | LARLAR | 10 Tackles, 4 Assists |
| 11. | 14.00 | Week 16, 2019 | Buf | @NE@NE | 10 Tackles, 1 Assist, 1 FF |
| 11. | 14.00 | Week 01, 2017 | Buf | NYJNYJ | 3 Tackles, 1.0 Sack, 1 Int, 2 PD |
| 11. | 14.00 | Week 03, 2016 | Cle | @Mia@Mia | 10 Tackles, 3 Assists, 1 PD |
| 11. | 14.00 | Week 07, 2015 | Cle | @Stl@Stl | 5 Tackles, 6 Assists, 1 Fum Rcvy |
| 17. | 13.00 | Week 15, 2019 | Buf | @Pit@Pit | 3 Tackles, 1 Assist, 1 Int, 1 Fum Rcvy, 1 PD |
| 17. | 13.00 | Week 01, 2019 | Buf | @NYJ@NYJ | 6 Tackles, 3 Assists, 1.0 Sack |
| 17. | 13.00 | Week 15, 2017 | Buf | MiaMia | 4 Tackles, 2 Assists, 1 Int, 2 PD |
| 17. | 13.00 | Week 11, 2017 | Buf | @LAC@LAC | 8 Tackles, 3 Assists, 2 PD |
| 21. | 12.00 | Week 18, 2022 | Buf | NENE | 7 Tackles, 2 Assists, 1 FF |
| 21. | 12.00 | Week 18, 2021 | Buf | NYJNYJ | 3 Tackles, 1 Assist, 2.0 Sacks |
| 21. | 12.00 | Week 02, 2020 | Buf | @Mia@Mia | 4 Tackles, 4 Assists, 1.0 Sack |
| 21. | 12.00 | Week 17, 2018 | Buf | MiaMia | 9 Tackles, 2 Assists, 1 PD |
| 21. | 12.00 | Week 04, 2018 | Buf | @GB@GB | 4 Tackles, 2 Assists, 1 Int, 1 PD |
| 21. | 12.00 | Week 05, 2017 | Buf | @Cin@Cin | 3 Tackles, 1 Int, 1 Fum Rcvy, 1 PD |
| 21. | 12.00 | Week 17, 2015 | Cle | PitPit | 3 Tackles, 2 Assists, 1 Int, 2 PD |
| 28. | 11.00 | Week 09, 2023 | Buf | @Cin@Cin | 8 Tackles, 3 Assists |
| 28. | 11.00 | Week 02, 2022 | Buf | TenTen | 3 Tackles, 1 Assist, 1 Int, 2 PD |
| 28. | 11.00 | Week 14, 2021 | Buf | @TB@TB | 7 Tackles, 3 Assists, 1 PD |
| 28. | 11.00 | Week 12, 2020 | Buf | LACLAC | 9 Tackles, 2 Assists |
| 28. | 11.00 | Week 10, 2020 | Buf | @ARI@ARI | 3 Tackles, 1 Assist, 1 Int, 2 PD |
| 28. | 11.00 | Week 08, 2020 | Buf | NENE | 11 Tackles |
| 28. | 11.00 | Week 07, 2020 | Buf | @NYJ@NYJ | 4 Tackles, 2 Assists, 1.0 Sack, 1 PD |
| 28. | 11.00 | Week 14, 2019 | Buf | BalBal | 5 Tackles, 5 Assists, 1 PD |
| 28. | 11.00 | Week 15, 2018 | Buf | DetDet | 10 Tackles, 1 Assist |
| 28. | 11.00 | Week 06, 2018 | Buf | @Hou@Hou | 4 Tackles, 1 Assist, 1 Int, 1 PD |
| 38. | 10.00 | Week 17, 2023 | Buf | NENE | 8 Tackles, 2 Assists |
| 38. | 10.00 | Week 08, 2023 | Buf | TBTB | 3 Tackles, 5 Assists, 2 PD |
| 38. | 10.00 | Week 12, 2022 | Buf | @Det@Det | 8 Tackles, 2 Assists |
| 38. | 10.00 | Week 06, 2021 | Buf | @TEN@TEN | 3 Tackles, 1 Assist, 1 Int, 1 PD |
| 38. | 10.00 | Week 01, 2021 | Buf | PITPIT | 5 Tackles, 1 Assist, 1.0 Sack |
| 38. | 10.00 | Week 06, 2020 | Buf | KCKC | 9 Tackles, 1 Assist |
| 38. | 10.00 | Week 09, 2019 | Buf | WasWas | 4 Tackles, 3 Assists, 1 FF |
| 38. | 10.00 | Week 10, 2018 | Buf | @NYJ@NYJ | 3 Tackles, 3 Assists, 1.0 Sack |
| 38. | 10.00 | Week 02, 2018 | Buf | LACLAC | 6 Tackles, 1 Assist, 1 FF |
| 38. | 10.00 | Week 13, 2017 | Buf | NENE | 5 Tackles, 5 Assists |
| 38. | 10.00 | Week 10, 2017 | Buf | NONO | 7 Tackles, 3 Assists |
| 38. | 10.00 | Week 10, 2015 | Cle | @Pit@Pit | 2 Tackles, 2 Assists, 1 Int, 1 PD |
| 50. | 9.00 | Week 10, 2023 | Buf | DenDen | 7 Tackles, 2 Assists |