*=Offensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 30.00 | Week 01, 2015 | SF | MinMin | 168 Rush, 14 Receiving, 2 TD |
| 2. | 26.00 | Week 14, 2016 | SF | NYJNYJ | 193 Rush, 7 Receiving, 1 TD |
| 3. | 24.00 | Week 03, 2016 | SF | @Sea@Sea | 103 Rush, 2 Receiving, 2 TD, 1 2-Pt |
| 4. | 23.30 | Week 03, 2018 | Cle | NYJNYJ | 98 Rush, 5 Receiving, 2 Rec, 2 TD |
| 5. | 21.00 | Week 17, 2017 | SF | @LAR@LAR | 90 Rush, 10 Receiving, 2 TD, 1 Fumb |
| 5. | 21.00 | Week 03, 2017 | SF | LARLAR | 84 Rush, 10 Receiving, 2 TD |
| 5. | 21.00 | Week 01, 2016 | SF | LALA | 88 Rush, 5 Receiving, 2 TD |
| 8. | 19.00 | Week 06, 2017 | SF | @Was@Was | 28 Rush, 47 Receiving, 2 TD |
| 9. | 18.50 | Week 06, 2019 | Hou | @KC@KC | 116 Rush, 14 Receiving, 1 Rec, 1 TD, 1 Fumb |
| 10. | 17.00 | Week 05, 2016 | SF | AriAri | 78 Rush, 36 Receiving, 1 TD |
| 11. | 16.50 | Week 11, 2020 | Sea | ARIARI | 79 Rush, 16 Receiving, 2 Rec, 1 TD |
| 12. | 16.40 | Week 15, 2019 | Hou | @Ten@Ten | 104 Rush, 1 TD |
| 13. | 15.10 | Week 07, 2020 | Sea | @ARI@ARI | 68 Rush, 8 Receiving, 3 Rec, 1 TD |
| 14. | 15.00 | Week 09, 2019 | Hou | @Jac@Jac | 160 Rush, 1 Fumb |
| 14. | 15.00 | Week 12, 2016 | SF | @Mia@Mia | 65 Rush, 30 Receiving, 1 TD |
| 14. | 15.00 | Week 05, 2015 | SF | @NYG@NYG | 93 Rush, 4 Receiving, 1 TD |
| 17. | 14.20 | Week 04, 2018 | Cle | @Oak@Oak | 82 Rush, 1 TD |
| 18. | 14.00 | Week 02, 2017 | SF | @Sea@Sea | 124 Rush, 19 Receiving |
| 19. | 13.30 | Week 15, 2020 | Sea | @WAS@WAS | 55 Rush, 8 Receiving, 2 Rec, 1 TD |
| 20. | 13.00 | Week 01, 2018 | Cle | PitPit | 62 Rush, 3 Receiving, 1 Rec, 1 TD |
| 20. | 13.00 | Week 16, 2017 | SF | JacJac | 54 Rush, 19 Receiving, 1 TD |
| 20. | 13.00 | Week 14, 2017 | SF | @Hou@Hou | 78 Rush, 1 TD |
| 20. | 13.00 | Week 04, 2016 | SF | DalDal | 74 Rush, 5 Receiving, 1 TD |
| 24. | 12.50 | Week 11, 2019 | Hou | @Bal@Bal | 65 Rush, 1 TD |
| 25. | 12.00 | Week 05, 2019 | Hou | AtlAtl | 60 Rush, 1 TD |
| 25. | 12.00 | Week 09, 2017 | SF | AriAri | 41 Rush, 84 Receiving |
| 27. | 11.50 | Week 02, 2018 | Cle | @NO@NO | 43 Rush, 7 Receiving, 1 Rec, 1 TD |
| 28. | 11.00 | Week 16, 2016 | SF | @LA@LA | 38 Rush, 24 Receiving, 1 TD, 1 Fumb |
| 28. | 11.00 | Week 11, 2016 | SF | NENE | 86 Rush, 24 Receiving |
| 28. | 11.00 | Week 01, 2014 | SF | @DAL@DAL | 50 Rush, 1 TD |
| 31. | 10.20 | Week 08, 2021 | Jac | @SEA@SEA | 32 Rush, 40 Receiving, 6 Rec |
| 31. | 10.20 | Week 16, 2019 | Hou | @TB@TB | 27 Rush, 10 Receiving, 1 Rec, 1 TD |
| 33. | 10.00 | Week 10, 2017 | SF | NYGNYG | 98 Rush, 6 Receiving |
| 34. | 9.00 | Week 02, 2019 | Hou | JacJac | |
| 34. | 9.00 | Week 01, 2019 | Hou | @NO@NO | 83 Rush, 2 Receiving, 1 Rec |
| 34. | 9.00 | Week 04, 2017 | SF | @Ari@Ari | 68 Rush, 27 Receiving |
| 34. | 9.00 | Week 13, 2016 | SF | @Chi@Chi | 92 Rush, 6 Receiving |
| 34. | 9.00 | Week 10, 2014 | SF | @NO@NO | 36 Rush, 1 TD |
| 39. | 8.80 | Week 14, 2019 | Hou | DenDen | 73 Rush, 5 Receiving, 2 Rec |
| 40. | 8.70 | Week 05, 2018 | Cle | BalBal | 63 Rush, 14 Receiving, 2 Rec |
| 41. | 8.40 | Week 04, 2019 | Hou | CarCar | 58 Rush, 6 Receiving, 4 Rec |
| 42. | 8.30 | Week 01, 2020 | Sea | @Atl@Atl | 23 Rush, 1 TD |
| 42. | 8.30 | Week 08, 2019 | Hou | OakOak | 83 Rush |
| 44. | 8.00 | Week 07, 2017 | SF | DalDal | 68 Rush, 20 Receiving |
| 45. | 7.90 | Week 03, 2019 | Hou | @LAC@LAC | 19 Rush, 1 TD |
| 46. | 7.80 | Week 13, 2021 | Jac | @LAR@LAR | 24 Rush, - 1 Receiving, 1 Rec, 1 TD, 1 Fumb |
| 47. | 7.00 | Week 01, 2017 | SF | CarCar | 45 Rush, 32 Receiving |
| 47. | 7.00 | Week 03, 2014 | SF | @Ari@Ari | 13 Rush, - 2 Receiving, 1 TD |
| 49. | 6.80 | Week 09, 2021 | Jac | BUFBUF | 67 Rush, 6 Receiving, 1 Rec, 1 Fumb |
| 49. | 6.80 | Week 01, 2021 | Jac | @HOU@HOU | 44 Rush, 14 Receiving, 2 Rec |