*=Offensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 36.64 | Week 07, 2019 | Ind | HouHou | 326 Pass, 6 Rush, 4 TD, 1 Fumb |
| 2. | 32.86 | Week 11, 2022 | Cle | @Buf@Buf | 324 Pass, 29 Rush, 3 TD, 1 Fumb |
| 3. | 29.00 | Week 03, 2017 | Ind | CleCle | 259 Pass, 14 Rush, 3 TD |
| 4. | 28.50 | Week 04, 2019 | Ind | OakOak | 265 Pass, 19 Rush, 3 TD, 1 Int |
| 5. | 27.14 | Week 14, 2019 | Ind | @TB@TB | 251 Pass, 26 Rush, 1 Rec, 2 TD, 1 2-Pt |
| 6. | 24.80 | Week 03, 2019 | Ind | AtlAtl | 310 Pass, 4 Rush, 2 TD |
| 7. | 24.00 | Week 09, 2017 | Ind | @Hou@Hou | 308 Pass, 12 Rush, 2 TD, 1 Fumb |
| 8. | 23.34 | Week 02, 2019 | Ind | @Ten@Ten | |
| 9. | 23.32 | Week 08, 2022 | Cle | CinCin | 278 Pass, 12 Rush, 2 TD, 1 Fumb |
| 10. | 21.90 | Week 03, 2022 | Cle | PitPit | 220 Pass, 11 Rush, 2 TD |
| 11. | 20.50 | Week 01, 2019 | Ind | @LAC@LAC | 190 Pass, 9 Rush, 2 TD |
| 12. | 20.30 | Week 03, 2021 | Mia | @LV@LV | 215 Pass, 37 Rush, 1 TD, 1 2-Pt |
| 13. | 20.00 | Week 05, 2021 | Mia | @TB@TB | 275 Pass, 2 TD, 1 Int, 1 Fumb |
| 14. | 19.76 | Week 04, 2021 | Mia | INDIND | 199 Pass, 8 Rush, 2 TD, 1 Fumb |
| 15. | 19.00 | Week 08, 2017 | Ind | @Cin@Cin | 233 Pass, 6 Rush, 2 TD, 1 Int |
| 16. | 18.48 | Week 10, 2022 | Cle | @Mia@Mia | 212 Pass, 40 Rush, 1 TD |
| 17. | 18.00 | Week 10, 2017 | Ind | PitPit | 222 Pass, 7 Rush, 2 TD, 1 Int |
| 18. | 17.86 | Week 15, 2023 | Was | @LAR@LAR | 124 Pass, 9 Rush, 2 TD |
| 19. | 17.46 | Week 02, 2022 | Cle | NYJNYJ | 229 Pass, 43 Rush, 1 TD, 1 Int |
| 20. | 17.12 | Week 11, 2019 | Ind | JacJac | 148 Pass, 12 Rush, 2 TD, 1 Int |
| 21. | 17.00 | Week 05, 2017 | Ind | SFSF | 314 Pass, 14 Rush, 1 TD, 1 Int |
| 22. | 16.40 | Week 05, 2022 | Cle | LACLAC | 230 Pass, 32 Rush, 1 TD, 1 Int |
| 23. | 15.16 | Week 16, 2019 | Ind | CarCar | 119 Pass, 37 Rush, 2 Receiving, 1 Rec, 1 TD |
| 24. | 15.10 | Week 12, 2022 | Cle | TBTB | 210 Pass, 27 Rush, 1 TD, 1 Int |
| 25. | 15.00 | Week 06, 2017 | Ind | @Ten@Ten | 212 Pass, 15 Rush, 1 TD |
| 26. | 14.96 | Week 04, 2022 | Cle | @Atl@Atl | 234 Pass, 16 Rush, 1 TD, 1 Int |
| 27. | 14.66 | Week 13, 2019 | Ind | TenTen | 319 Pass, - 1 Rush, 1 TD, 2 Int |
| 28. | 14.00 | Week 16, 2017 | Ind | @Bal@Bal | 215 Pass, 8 Rush, 1 TD |
| 28. | 14.00 | Week 03, 2016 | NE | HouHou | 103 Pass, 48 Rush, 1 TD |
| 30. | 13.16 | Week 12, 2019 | Ind | @Hou@Hou | 129 Pass, 20 Rush, 1 TD |
| 31. | 13.00 | Week 15, 2017 | Ind | DenDen | 158 Pass, 18 Rush, 1 TD |
| 32. | 12.88 | Week 01, 2022 | Cle | @CAR@CAR | 147 Pass, 10 Rush, 1 TD |
| 33. | 12.30 | Week 12, 2020 | Ind | TENTEN | |
| 34. | 12.00 | Week 04, 2017 | Ind | @Sea@Sea | 157 Pass, 33 Rush, 1 TD, 1 Int, 1 Fumb |
| 35. | 11.64 | Week 06, 2022 | Cle | NENE | 266 Pass, 1 TD, 2 Int, 1 Fumb |
| 36. | 11.46 | Week 09, 2021 | Mia | HOUHOU | 244 Pass, 7 Rush, 1 TD, 2 Int, 1 Fumb |
| 37. | 11.12 | Week 07, 2022 | Cle | @Bal@Bal | 258 Pass, 18 Rush, 1 Fumb |
| 38. | 11.00 | Week 16, 2023 | Was | @NYJ@NYJ | |
| 38. | 11.00 | Week 17, 2017 | Ind | HouHou | 114 Pass, 18 Rush, 1 TD |
| 38. | 11.00 | Week 13, 2017 | Ind | @Jac@Jac | 174 Pass, 36 Rush, 1 TD, 2 Int |
| 38. | 11.00 | Week 07, 2017 | Ind | JacJac | 200 Pass, 31 Rush |
| 42. | 10.94 | Week 05, 2019 | Ind | @KC@KC | 151 Pass, 9 Rush, 1 TD, 1 Int |
| 43. | 10.48 | Week 08, 2019 | Ind | DenDen | 202 Pass, 34 Rush, 1 Fumb |
| 44. | 9.00 | Week 14, 2017 | Ind | @Buf@Buf | 69 Pass, 10 Rush, 1 TD |
| 44. | 9.00 | Week 04, 2016 | NE | BufBuf | 205 Pass, 23 Rush, 1 Fumb |
| 46. | 8.00 | Week 02, 2017 | Ind | AriAri | 216 Pass, 22 Rush, 1 Int |
| 47. | 7.30 | Week 15, 2019 | Ind | @NO@NO | 165 Pass, 7 Rush |
| 48. | 7.00 | Week 12, 2017 | Ind | TenTen | 196 Pass, 16 Rush, 1 Fumb |
| 49. | 6.64 | Week 10, 2021 | Mia | BALBAL | 156 Pass, 4 Rush |
| 50. | 6.20 | Week 10, 2020 | Ind | @TEN@TEN | 2 Rush, 1 TD |