*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 17.00 | Week 09, 2020 | Buf | SEASEA | 6 Tackles, 2 Assists, 1 Int, 1 Fum Rcvy, 1 PD |
| 2. | 16.00 | Week 15, 2019 | Buf | @Pit@Pit | 3 Tackles, 1 Assist, 2 Int, 2 PD |
| 2. | 16.00 | Week 03, 2017 | Buf | DenDen | 6 Tackles, 1 Assist, 1 Int, 4 PD |
| 4. | 15.00 | Week 12, 2020 | Buf | LACLAC | 4 Tackles, 4 Assists, 1 Int, 2 PD |
| 4. | 15.00 | Week 15, 2017 | Buf | MiaMia | 3 Tackles, 4 Assists, 1 Int, 3 PD |
| 6. | 14.00 | Week 07, 2019 | Buf | MiaMia | 4 Tackles, 1 Assist, 1 Int, 1 FF, 1 PD |
| 6. | 14.00 | Week 04, 2017 | Buf | @Atl@Atl | 3 Tackles, 1 Assist, 1 TD, 1 Fum Rcvy, 1 PD |
| 8. | 13.00 | Week 03, 2019 | Buf | CinCin | 1 Tackle, 2 Int, 2 PD |
| 9. | 12.00 | Week 15, 2020 | Buf | @DEN@DEN | 3 Tackles, 1.0 Sack, 1 FF, 2 PD |
| 9. | 12.00 | Week 12, 2019 | Buf | DenDen | 3 Tackles, 1 Int, 4 PD |
| 11. | 11.00 | Week 10, 2021 | Buf | @NYJ@NYJ | 3 Tackles, 2 Assists, 1 Int, 1 PD |
| 11. | 11.00 | Week 13, 2017 | Buf | NENE | 4 Tackles, 1 Assist, 1 Int, 1 PD |
| 13. | 10.00 | Week 18, 2022 | Buf | NENE | 2 Tackles, 2 Assists, 1 Int, 1 PD |
| 13. | 10.00 | Week 13, 2020 | Buf | @SF@SF | 3 Tackles, 1 Assist, 1 Int, 1 PD |
| 13. | 10.00 | Week 10, 2019 | Buf | @Cle@Cle | 6 Tackles, 4 PD |
| 16. | 9.00 | Week 03, 2023 | Buf | @Was@Was | 3 Tackles, 1 Int, 1 PD |
| 16. | 9.00 | Week 09, 2021 | Buf | @Jac@Jac | 2 Tackles, 4 Assists, 0.5 Sack, 1 PD |
| 16. | 9.00 | Week 02, 2021 | Buf | @MIA@MIA | 7 Tackles, 2 Assists |
| 16. | 9.00 | Week 04, 2020 | Buf | @LV@LV | 6 Tackles, 2 Assists, 1 PD |
| 16. | 9.00 | Week 09, 2018 | Buf | ChiChi | 2 Tackles, 1 Assist, 1 Int, 1 PD |
| 16. | 9.00 | Week 08, 2018 | Buf | NENE | 6 Tackles, 2 Assists, 1 PD |
| 22. | 8.00 | Week 05, 2021 | Buf | @KC@KC | 3 Tackles, 2 Assists, 1 Fum Rcvy |
| 22. | 8.00 | Week 09, 2019 | Buf | WasWas | 3 Tackles, 1 Assist, 1.0 Sack |
| 22. | 8.00 | Week 02, 2019 | Buf | @NYG@NYG | |
| 22. | 8.00 | Week 17, 2018 | Buf | MiaMia | 2 Tackles, 1 Int, 1 PD |
| 22. | 8.00 | Week 04, 2018 | Buf | @GB@GB | 5 Tackles, 3 PD |
| 27. | 7.00 | Week 11, 2021 | Buf | INDIND | 5 Tackles, 2 Assists |
| 27. | 7.00 | Week 08, 2019 | Buf | PhiPhi | 3 Tackles, 2 Assists, 2 PD |
| 27. | 7.00 | Week 17, 2017 | Buf | @Mia@Mia | 5 Tackles, 2 Assists |
| 27. | 7.00 | Week 12, 2017 | Buf | @KC@KC | 1 Tackle, 1 Int, 1 PD |
| 27. | 7.00 | Week 07, 2017 | Buf | TBTB | 1 Tackle, 1 FF, 1 Fum Rcvy |
| 27. | 7.00 | Week 02, 2017 | Buf | @Car@Car | 4 Tackles, 2 Assists, 1 PD |
| 33. | 6.00 | Week 16, 2022 | Buf | @Chi@Chi | 4 Tackles, 1 Assist, 1 PD |
| 33. | 6.00 | Week 15, 2022 | Buf | MiaMia | 3 Tackles, 3 PD |
| 33. | 6.00 | Week 03, 2021 | Buf | WASWAS | 2 Tackles, 1 Assist, 1 FF |
| 33. | 6.00 | Week 07, 2020 | Buf | @NYJ@NYJ | 2 Tackles, 2 Assists, 0.5 Sack |
| 33. | 6.00 | Week 06, 2020 | Buf | KCKC | 4 Tackles, 2 Assists |
| 33. | 6.00 | Week 02, 2020 | Buf | @Mia@Mia | 4 Tackles, 2 PD |
| 33. | 6.00 | Week 13, 2019 | Buf | @Dal@Dal | 1 Tackle, 3 Assists, 2 PD |
| 33. | 6.00 | Week 11, 2019 | Buf | @Mia@Mia | 6 Tackles |
| 33. | 6.00 | Week 15, 2018 | Buf | DetDet | 5 Tackles, 1 Assist |
| 33. | 6.00 | Week 01, 2017 | Buf | NYJNYJ | 4 Tackles, 2 PD |
| 43. | 5.00 | Week 13, 2022 | Buf | @NE@NE | 3 Tackles, 1 Assist, 1 PD |
| 43. | 5.00 | Week 14, 2020 | Buf | PITPIT | 3 Tackles, 1 Assist, 1 PD |
| 43. | 5.00 | Week 03, 2018 | Buf | @Min@Min | 4 Tackles, 1 PD |
| 43. | 5.00 | Week 16, 2017 | Buf | @NE@NE | 3 Tackles, 2 Assists |
| 43. | 5.00 | Week 11, 2017 | Buf | @LAC@LAC | 4 Tackles, 1 Assist |
| 43. | 5.00 | Week 10, 2017 | Buf | NONO | 3 Tackles, 1 Assist, 1 PD |
| 43. | 5.00 | Week 09, 2017 | Buf | @NYJ@NYJ | 4 Tackles, 1 Assist |
| 43. | 5.00 | Week 05, 2017 | Buf | @Cin@Cin | 2 Tackles, 3 PD |