*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 8.00 | Week 02, 2019 | Buf | @NYG@NYG | |
| 2. | 7.00 | Week 01, 2019 | Buf | @NYJ@NYJ | 5 Tackles, 2 Assists |
| 3. | 6.00 | Week 05, 2022 | Buf | PitPit | 1 Tackle, 1 Assist, 4 PD |
| 3. | 6.00 | Week 17, 2019 | Buf | NYJNYJ | 5 Tackles, 1 Assist |
| 3. | 6.00 | Week 03, 2019 | Buf | CinCin | 6 Tackles |
| 3. | 6.00 | Week 17, 2018 | Buf | MiaMia | 6 Tackles |
| 7. | 5.00 | Week 16, 2022 | Buf | @Chi@Chi | 3 Tackles, 2 Assists |
| 7. | 5.00 | Week 09, 2021 | Buf | @Jac@Jac | 4 Tackles, 1 Assist |
| 7. | 5.00 | Week 05, 2021 | Buf | @KC@KC | 1 Tackle, 1 Assist, 1 FF |
| 7. | 5.00 | Week 14, 2018 | Buf | NYJNYJ | 2 Tackles, 1 FF |
| 7. | 5.00 | Week 04, 2018 | Buf | @GB@GB | 1 Tackle, 1.0 Sack |
| 12. | 4.00 | Week 11, 2023 | Buf | NYJNYJ | 4 Tackles |
| 12. | 4.00 | Week 17, 2021 | Buf | ATLATL | 4 Tackles |
| 12. | 4.00 | Week 08, 2021 | Buf | MIAMIA | 2 Tackles, 2 Assists |
| 12. | 4.00 | Week 04, 2021 | Buf | HOUHOU | 2 Tackles, 2 Assists |
| 12. | 4.00 | Week 17, 2020 | Buf | MIAMIA | 2 Tackles, 1 Assist, 1 PD |
| 12. | 4.00 | Week 05, 2019 | Buf | @Ten@Ten | 2 Tackles, 2 Assists |
| 18. | 3.00 | Week 13, 2021 | Buf | NENE | 1 Fum Rcvy |
| 18. | 3.00 | Week 14, 2020 | Buf | PITPIT | 3 Assists |
| 18. | 3.00 | Week 08, 2019 | Buf | PhiPhi | 1 FF |
| 18. | 3.00 | Week 06, 2018 | Buf | @Hou@Hou | 1 Fum Rcvy |
| 22. | 2.00 | Week 06, 2023 | Buf | NYGNYG | 2 Tackles |
| 22. | 2.00 | Week 04, 2023 | Buf | MiaMia | 2 Tackles |
| 22. | 2.00 | Week 03, 2023 | Buf | @Was@Was | 2 Assists |
| 22. | 2.00 | Week 14, 2022 | Buf | NYJNYJ | 2 Tackles |
| 22. | 2.00 | Week 13, 2022 | Buf | @NE@NE | 2 Tackles |
| 22. | 2.00 | Week 08, 2022 | Buf | GBGB | 2 Tackles |
| 22. | 2.00 | Week 06, 2022 | Buf | @KC@KC | 2 Tackles |
| 22. | 2.00 | Week 02, 2022 | Buf | TenTen | 1 Tackle, 1 Assist |
| 22. | 2.00 | Week 12, 2021 | Buf | @NO@NO | 1 Tackle, 1 Assist |
| 22. | 2.00 | Week 10, 2021 | Buf | @NYJ@NYJ | 2 Tackles |
| 22. | 2.00 | Week 01, 2021 | Buf | PITPIT | 2 Tackles |
| 22. | 2.00 | Week 10, 2020 | Buf | @ARI@ARI | 2 Tackles |
| 22. | 2.00 | Week 08, 2020 | Buf | NENE | 2 Tackles |
| 22. | 2.00 | Week 06, 2020 | Buf | KCKC | 2 Tackles |
| 22. | 2.00 | Week 14, 2019 | Buf | BalBal | 2 Tackles |
| 22. | 2.00 | Week 02, 2018 | Buf | LACLAC | 2 Tackles |
| 38. | 1.00 | Week 15, 2023 | Buf | DalDal | 1 Assist |
| 38. | 1.00 | Week 05, 2023 | Buf | JacJac | 1 Assist |
| 38. | 1.00 | Week 01, 2023 | Buf | @NYJ@NYJ | 1 Tackle |
| 38. | 1.00 | Week 17, 2022 | Buf | @Cin@Cin | 1 Assist |
| 38. | 1.00 | Week 09, 2022 | Buf | @NYJ@NYJ | 1 Assist |
| 38. | 1.00 | Week 01, 2022 | Buf | @LAR@LAR | 1 Assist |
| 38. | 1.00 | Week 16, 2021 | Buf | @NE@NE | 1 Tackle |
| 38. | 1.00 | Week 06, 2021 | Buf | @TEN@TEN | 1 Tackle |
| 38. | 1.00 | Week 02, 2021 | Buf | @MIA@MIA | 1 Assist |
| 38. | 1.00 | Week 16, 2020 | Buf | @NE@NE | 1 Tackle |
| 38. | 1.00 | Week 15, 2020 | Buf | @DEN@DEN | 1 Assist |
| 38. | 1.00 | Week 02, 2020 | Buf | @Mia@Mia | 1 Tackle |
| 38. | 1.00 | Week 16, 2019 | Buf | @NE@NE | 1 Assist |