*=Offensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 51.00 | Week 06, 2009 * | NE | TenTen | 380 Pass, 6 TD |
| 2. | 50.00 | Week 07, 2007 * | NE | @Mia@Mia | 354 Pass, 6 TD |
| 3. | 47.74 | Week 05, 2021 | TB | MIAMIA | 411 Pass, 13 Rush, 5 TD |
| 4. | 46.00 | Week 03, 2017 * | NE | HouHou | 378 Pass, 6 Rush, 5 TD, 1 2-Pt, 1 Fumb |
| 5. | 44.86 | Week 07, 2020 | TB | @LV@LV | 369 Pass, 1 Rush, 5 TD |
| 6. | 44.00 | Week 08, 2014 | NE | ChiChi | 354 Pass, 5 TD |
| 6. | 44.00 | Week 11, 2007 * | NE | @Buf@Buf | 373 Pass, 9 Rush, 5 TD |
| 6. | 44.00 | Week 06, 2007 | NE | @Dal@Dal | 388 Pass, 5 Rush, 5 TD, 1 Fumb |
| 9. | 43.68 | Week 17, 2022 | TB | CarCar | 432 Pass, 4 Rush, 4 TD, 1 2-Pt |
| 10. | 42.46 | Week 04, 2020 | TB | LACLAC | 369 Pass, - 3 Rush, 5 TD, 1 Int |
| 11. | 42.00 | Week 01, 2011 * | NE | @Mia@Mia | 517 Pass, 3 Rush, 4 TD, 1 Int |
| 11. | 42.00 | Week 08, 2007 * | NE | WasWas | 306 Pass, 14 Rush, 5 TD, 1 Fumb |
| 13. | 41.00 | Week 09, 2013 | NE | PitPit | 432 Pass, - 1 Rush, 4 TD |
| 14. | 40.64 | Week 02, 2021 | TB | ATLATL | 276 Pass, 6 Rush, 5 TD, 1 Fumb |
| 15. | 39.00 | Week 14, 2007 * | NE | PitPit | 399 Pass, 4 Rush, 4 TD |
| 16. | 38.26 | Week 17, 2020 | TB | ATLATL | 399 Pass, 3 Rush, 4 TD, 1 Int |
| 17. | 38.00 | Week 08, 2015 | NE | MiaMia | 356 Pass, 1 Rush, 4 TD |
| 17. | 38.00 | Week 06, 2014 | NE | @Buf@Buf | 361 Pass, 3 Rush, 4 TD |
| 17. | 38.00 | Week 10, 2010 | NE | @Pit@Pit | 350 Pass, 3 Rush, 4 TD |
| 17. | 38.00 | Week 03, 2002 | NE | KCKC | 410 Pass, 2 Rush, 4 TD, 1 Int |
| 21. | 37.92 | Week 16, 2020 | TB | @DET@DET | 348 Pass, 4 TD |
| 22. | 37.84 | Week 10, 2020 * | TB | @CAR@CAR | 341 Pass, 2 Rush, 4 TD |
| 23. | 37.00 | Week 08, 2016 | NE | @Buf@Buf | 315 Pass, 15 Rush, 4 TD |
| 23. | 37.00 | Week 13, 2015 | NE | PhiPhi | 312 Pass, 17 Rush, 36 Receiving, 4 TD, 2 Int |
| 23. | 37.00 | Week 04, 2012 * | NE | @Buf@Buf | 340 Pass, 4 Rush, 4 TD |
| 23. | 37.00 | Week 13, 2010 * | NE | NYJNYJ | 326 Pass, 3 Rush, 4 TD |
| 23. | 37.00 | Week 12, 2010 | NE | @Det@Det | 341 Pass, 1 Rush, 4 TD |
| 28. | 36.62 | Week 13, 2021 * | TB | @ATL@ATL | 368 Pass, - 1 Rush, 4 TD, 1 Int |
| 29. | 36.00 | Week 11, 2016 * | NE | @SF@SF | 280 Pass, 12 Rush, 4 TD |
| 29. | 36.00 | Week 12, 2012 | NE | @NYJ@NYJ | 323 Pass, 5 Rush, 4 TD |
| 29. | 36.00 | Week 08, 2012 | NE | @StL@StL | 304 Pass, 3 Rush, 4 TD |
| 29. | 36.00 | Week 08, 2006 | NE | @Min@Min | 372 Pass, 1 Rush, 4 TD, 1 Int |
| 29. | 36.00 | Week 09, 2002 | NE | @Buf@Buf | 310 Pass, -1 Rush, 4 TD |
| 34. | 35.16 | Week 01, 2021 | TB | DALDAL | 379 Pass, 4 TD, 2 Int |
| 35. | 35.00 | Week 02, 2017 * | NE | @NO@NO | 447 Pass, 9 Rush, 3 TD |
| 35. | 35.00 | Week 05, 2016 | NE | @Cle@Cle | 406 Pass, 14 Rush, 3 TD |
| 35. | 35.00 | Week 02, 2015 | NE | @Buf@Buf | 466 Pass, - 4 Rush, 3 TD, 1 Fumb |
| 35. | 35.00 | Week 01, 2015 * | NE | PitPit | 288 Pass, 1 Rush, 4 TD |
| 35. | 35.00 | Week 09, 2014 | NE | DenDen | 333 Pass, 4 Rush, 4 TD, 1 Int |
| 35. | 35.00 | Week 14, 2012 | NE | HouHou | 296 Pass, 6 Rush, 4 TD |
| 35. | 35.00 | Week 03, 2007 | NE | BufBuf | 311 Pass, 2 Rush, 4 TD, 1 Fumb |
| 35. | 35.00 | Week 11, 2001 * | NE | NONO | 258 Pass, 14 Rush, 4 TD |
| 43. | 34.20 | Week 08, 2021 * | TB | @NO@NO | 375 Pass, 2 Rush, 4 TD, 2 Int, 1 Fumb |
| 44. | 34.12 | Week 14, 2021 | TB | BUFBUF | 363 Pass, 16 Rush, 3 TD |
| 45. | 34.00 | Week 17, 2018 | NE | NYJNYJ | 250 Pass, 4 TD |
| 45. | 34.00 | Week 12, 2011 | NE | @Phi@Phi | 361 Pass, 28 Rush, 3 TD |
| 45. | 34.00 | Week 02, 2011 * | NE | SDSD | 423 Pass, 3 Rush, 3 TD |
| 45. | 34.00 | Week 16, 2009 | NE | JacJac | 267 Pass, 4 Rush, 4 TD |
| 49. | 33.54 | Week 05, 2018 | NE | IndInd | 341 Pass, - 1 Rush, 4 TD, 2 Int |
| 50. | 33.00 | Week 06, 2016 | NE | CinCin | 376 Pass, 2 Rush, 3 TD |