*=Offensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 56.00 | Week 08, 2014 * | Pit | IndInd | 522 Pass, - 1 Rush, 6 TD |
| 2. | 48.00 | Week 09, 2014 * | Pit | BalBal | 340 Pass, 1 Rush, 6 TD, 1 Fumb |
| 3. | 45.82 | Week 10, 2018 * | Pit | CarCar | 328 Pass, 27 Rush, 5 TD |
| 4. | 44.98 | Week 02, 2018 | Pit | KCKC | 452 Pass, 9 Rush, 4 TD, 1 2-Pt |
| 5. | 44.00 | Week 04, 2016 * | Pit | KCKC | 300 Pass, - 1 Rush, 5 TD, 1 2-Pt |
| 6. | 41.00 | Week 13, 2015 | Pit | IndInd | 364 Pass, 13 Rush, 4 TD, 1 2-Pt |
| 7. | 40.00 | Week 11, 2010 * | Pit | OakOak | 275 Pass, 55 Rush, 4 TD |
| 8. | 39.00 | Week 11, 2013 * | Pit | DetDet | 367 Pass, 12 Rush, 4 TD |
| 8. | 39.00 | Week 03, 2012 * | Pit | @Oak@Oak | 384 Pass, 8 Rush, 4 TD |
| 10. | 38.00 | Week 12, 2017 | Pit | GBGB | 351 Pass, 25 Rush, 4 TD, 2 Int, 1 2-Pt |
| 10. | 38.00 | Week 05, 2016 * | Pit | NYJNYJ | 380 Pass, 4 TD, 1 Fumb |
| 10. | 38.00 | Week 15, 2009 | Pit | GBGB | 503 Pass, 7 Rush, 3 TD |
| 10. | 38.00 | Week 09, 2007 | Pit | BalBal | 209 Pass, 5 TD |
| 14. | 37.32 | Week 10, 2020 | Pit | CINCIN | 333 Pass, 4 TD |
| 15. | 37.00 | Week 05, 2011 * | Pit | TenTen | 228 Pass, 5 TD, 1 Int |
| 16. | 36.00 | Week 11, 2017 * | Pit | TenTen | 299 Pass, 10 Rush, 4 TD |
| 16. | 36.00 | Week 02, 2015 * | Pit | SFSF | 369 Pass, - 1 Rush, 3 TD, 2 2-Pt |
| 18. | 35.60 | Week 16, 2018 | Pit | @NO@NO | 380 Pass, 4 Rush, 3 TD, 1 2-Pt |
| 19. | 35.00 | Week 09, 2013 | Pit | @NE@NE | 400 Pass, - 1 Rush, 4 TD, 2 Int, 1 Fumb |
| 20. | 34.00 | Week 10, 2016 | Pit | DalDal | 408 Pass, 1 Rush, 3 TD |
| 20. | 34.00 | Week 14, 2014 | Pit | @Cin@Cin | 350 Pass, - 1 Rush, 3 TD, 1 2-Pt |
| 22. | 33.00 | Week 10, 2007 | Pit | CleCle | 278 Pass, 49 Rush, 3 TD, 1 Int, 1 2-Pt |
| 23. | 32.00 | Week 14, 2017 | Pit | BalBal | 506 Pass, 5 Rush, 2 TD |
| 23. | 32.00 | Week 07, 2011 | Pit | @Ari@Ari | 361 Pass, - 2 Rush, 3 TD |
| 23. | 32.00 | Week 10, 2010 | Pit | NENE | 387 Pass, 12 Rush, 3 TD, 1 Int |
| 23. | 32.00 | Week 07, 2007 | Pit | @Den@Den | 290 Pass, 20 Rush, 4 TD, 2 Int, 1 Fumb |
| 27. | 31.48 | Week 16, 2020 | Pit | INDIND | 342 Pass, - 2 Rush, 3 TD |
| 28. | 31.04 | Week 09, 2020 | Pit | @DAL@DAL | 306 Pass, 8 Rush, 3 TD |
| 29. | 31.00 | Week 10, 2015 | Pit | CleCle | 379 Pass, - 2 Rush, 3 TD, 1 Int |
| 30. | 30.82 | Week 14, 2021 | Pit | @MIN@MIN | 308 Pass, 5 Rush, 3 TD, 1 Int, 1 2-Pt |
| 31. | 30.02 | Week 03, 2018 | Pit | @TB@TB | 353 Pass, - 1 Rush, 3 TD, 1 Int |
| 32. | 30.00 | Week 14, 2013 | Pit | MiaMia | 349 Pass, 8 Rush, 3 TD, 1 Fumb |
| 32. | 30.00 | Week 01, 2007 | Pit | @Cle@Cle | 161 Pass, 2 Rush, 4 TD |
| 34. | 29.20 | Week 09, 2018 | Pit | @Bal@Bal | 270 Pass, 4 Rush, 3 TD |
| 35. | 29.00 | Week 15, 2015 | Pit | DenDen | 380 Pass, - 3 Rush, 3 TD, 2 Int |
| 35. | 29.00 | Week 13, 2014 | Pit | NONO | 435 Pass, 8 Rush, 2 TD, 2 Int, 2 2-Pt |
| 35. | 29.00 | Week 04, 2014 | Pit | TBTB | 314 Pass, 4 Rush, - 6 Receiving, 3 TD, 1 Fumb |
| 35. | 29.00 | Week 14, 2012 | Pit | SDSD | 285 Pass, 31 Rush, 3 TD, 1 Int, 1 Fumb |
| 35. | 29.00 | Week 11, 2009 | Pit | @KC@KC | 398 Pass, 4 Rush, 3 TD, 2 Int |
| 35. | 29.00 | Week 16, 2007 | Pit | @StL@StL | 261 Pass, 11 Rush, 3 TD |
| 41. | 28.92 | Week 11, 2021 | Pit | @LAC@LAC | 273 Pass, 3 TD |
| 42. | 28.06 | Week 01, 2020 | Pit | @NYG@NYG | 229 Pass, 9 Rush, 3 TD |
| 43. | 28.00 | Week 01, 2016 | Pit | @Was@Was | 300 Pass, - 2 Rush, 3 TD, 1 Int |
| 43. | 28.00 | Week 05, 2008 | Pit | @Jac@Jac | 309 Pass, 2 Rush, 3 TD, 1 Int |
| 43. | 28.00 | Week 10, 2006 | Pit | NONO | 264 Pass, 1 Rush, 3 TD |
| 46. | 27.60 | Week 05, 2018 | Pit | AtlAtl | 250 Pass, 16 Rush, 3 TD, 1 Int |
| 47. | 27.36 | Week 05, 2020 | Pit | PHIPHI | 239 Pass, - 2 Rush, 3 TD |
| 48. | 27.00 | Week 17, 2015 | Pit | @Cle@Cle | 349 Pass, - 2 Rush, 3 TD, 2 Int |
| 48. | 27.00 | Week 05, 2009 | Pit | @Det@Det | 277 Pass, - 3 Rush, 3 TD, 1 Int |
| 48. | 27.00 | Week 13, 2005 | Pit | CinCin | 386 Pass, 2 Rush, 3 TD, 3 Int |