*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 32.00 | Week 16, 2007 | SF | TBTB | 12 Tackles, 8 Assists, 2.0 Sacks, 1 FF, 1 PD |
| 2. | 30.00 | Week 04, 2009 * | SF | StLStL | 5 Tackles, 3 Assists, 2.5 Sacks, 1 Int, 1 TD, 1 PD |
| 3. | 22.00 | Week 05, 2008 | SF | NENE | 14 Tackles, 4 Assists, 1.0 Sack |
| 4. | 21.00 | Week 11, 2010 | SF | TBTB | 9 Tackles, 4 Assists, 2.0 Sacks |
| 4. | 21.00 | Week 12, 2007 | SF | @Ari@Ari | 17 Tackles, 1 Assist, 0.5 Sack, 1 PD |
| 6. | 20.00 | Week 09, 2011 | SF | @Was@Was | 9 Tackles, 4 Assists, 2 FF, 1 PD |
| 6. | 20.00 | Week 02, 2008 | SF | @Sea@Sea | 8 Tackles, 1 Int, 1 TD, 1 PD |
| 8. | 19.00 | Week 16, 2013 | SF | AtlAtl | 15 Tackles, 3 Assists, 1 PD |
| 8. | 19.00 | Week 16, 2010 | SF | @StL@StL | 12 Tackles, 1.0 Sack, 1 FF |
| 8. | 19.00 | Week 01, 2009 | SF | @Ari@Ari | 11 Tackles, 2 Assists, 1 Int, 1 PD |
| 11. | 18.00 | Week 11, 2011 | SF | AriAri | 6 Tackles, 1 Assist, 1 Int, 1 FF, 3 PD |
| 11. | 18.00 | Week 10, 2010 | SF | StLStL | 8 Tackles, 3 Assists, 1.0 Sack, 1 FF |
| 11. | 18.00 | Week 05, 2009 | SF | AtlAtl | 6 Tackles, 6 Assists, 2 FF |
| 11. | 18.00 | Week 13, 2008 | SF | @Buf@Buf | 10 Tackles, 4 Assists, 1 FF, 1 PD |
| 11. | 18.00 | Week 13, 2007 | SF | @Car@Car | 17 Tackles, 1 Assist |
| 16. | 17.00 | Week 04, 2012 | SF | @NYJ@NYJ | 3 Tackles, 7 Assists, 1 Int, 2 PD |
| 16. | 17.00 | Week 17, 2007 | SF | @Cle@Cle | 12 Tackles, 1.0 Sack, 1 PD |
| 18. | 16.00 | Week 05, 2011 | SF | TBTB | 10 Tackles, 2 Assists, 1 Fum Rcvy, 1 PD |
| 18. | 16.00 | Week 14, 2009 | SF | AriAri | 9 Tackles, 1.0 Sack, 1 FF |
| 18. | 16.00 | Week 13, 2009 | SF | @Sea@Sea | 12 Tackles, 4 Assists |
| 21. | 15.00 | Week 10, 2011 | SF | NYGNYG | 9 Tackles, 2 Assists, 1.0 Sack |
| 21. | 15.00 | Week 16, 2009 | SF | DetDet | 6 Tackles, 3 Assists, 1 Int, 1 PD |
| 23. | 14.00 | Week 09, 2007 | SF | @Atl@Atl | 8 Tackles, 2 Assists, 1.0 Sack |
| 23. | 14.00 | Week 01, 2007 | SF | AriAri | 9 Tackles, 2 Assists, 1 FF |
| 25. | 13.00 | Week 03, 2012 | SF | @Min@Min | 5 Tackles, 5 Assists, 1 Fum Rcvy |
| 25. | 13.00 | Week 02, 2010 | SF | NONO | 8 Tackles, 1 Assist, 1.0 Sack |
| 25. | 13.00 | Week 12, 2009 | SF | JacJac | 6 Tackles, 5 Assists, 0.5 Sack |
| 25. | 13.00 | Week 16, 2008 | SF | @StL@StL | 13 Tackles |
| 25. | 13.00 | Week 04, 2008 | SF | @NO@NO | 9 Tackles, 1 Fum Rcvy, 1 PD |
| 25. | 13.00 | Week 07, 2007 | SF | @NYG@NYG | 11 Tackles, 2 Assists |
| 31. | 12.00 | Week 01, 2014 | SF | @DAL@DAL | 6 Tackles, 1 Int, 1 PD |
| 31. | 12.00 | Week 16, 2012 | SF | @Sea@Sea | 2 Tackles, 4 Assists, 1 Int, 1 PD |
| 31. | 12.00 | Week 12, 2012 | SF | @NO@NO | 7 Tackles, 3 Assists, 0.5 Sack |
| 31. | 12.00 | Week 02, 2011 | SF | DalDal | 8 Tackles, 1 Assist, 1 FF |
| 31. | 12.00 | Week 07, 2008 | SF | @NYG@NYG | 8 Tackles, 1 Assist, 3 PD |
| 31. | 12.00 | Week 05, 2007 | SF | BalBal | 6 Tackles, 6 Assists |
| 31. | 12.00 | Week 04, 2007 | SF | SeaSea | 10 Tackles, 2 Assists |
| 38. | 11.00 | Week 12, 2013 | SF | @Was@Was | 7 Tackles, 4 Assists |
| 38. | 11.00 | Week 10, 2013 | SF | CarCar | 6 Tackles, 1 Assist, 1.0 Sack |
| 38. | 11.00 | Week 06, 2013 | SF | AriAri | 6 Tackles, 2 Assists, 1 FF |
| 38. | 11.00 | Week 15, 2012 | SF | @NE@NE | 5 Tackles, 6 Assists |
| 38. | 11.00 | Week 08, 2011 | SF | CleCle | 6 Tackles, 1 Assist, 1.0 Sack |
| 38. | 11.00 | Week 07, 2010 | SF | @Car@Car | 8 Tackles, 3 Assists |
| 38. | 11.00 | Week 10, 2009 | SF | ChiChi | 8 Tackles, 3 Assists |
| 38. | 11.00 | Week 07, 2009 | SF | @Hou@Hou | 8 Tackles, 2 Assists, 1 PD |
| 38. | 11.00 | Week 10, 2008 | SF | @Ari@Ari | 9 Tackles, 2 Assists |
| 38. | 11.00 | Week 14, 2007 | SF | MinMin | 6 Tackles, 2 Assists, 1 Fum Rcvy |
| 48. | 10.00 | Week 15, 2013 | SF | @TB@TB | 6 Tackles, 1.0 Sack |
| 48. | 10.00 | Week 07, 2012 | SF | SeaSea | 7 Tackles, 1 Assist, 2 PD |
| 48. | 10.00 | Week 05, 2012 | SF | BufBuf | 7 Tackles, 1 FF |