| Player | Position | Proteam | Games | Qualfied Since |
| Catchers | ||||
| David Fry | 1B (C,OF) | Cle | 23 | Week 5 |
| Mitch Garver | DH (C) | Sea | 10 | Week 13 |
| Hunter Goodman | OF (C) | Col | 10 | Week 13 |
| Blake Sabol | OF (C) | SF | 8 | Week 7 |
| Matt Thaiss | 1B (C) | LAA | 25 | Week 4 |
| 1st Basemen | ||||
| Luis Arraez | 2B (1B) | SD | 52 | Week 5 |
| Cody Bellinger | OF (1B) | ChN | 13 | Week 11 |
| Cavan Biggio | 2B (1B,3B,OF) | LAD | 7 | Week 14 |
| Tyler Black | 3B (1B) | Mil | 6 | Week 13 |
| Alec Bohm | 3B (1B) | Phi | 13 | Week 7 |
| Trenton Brooks | OF (1B) | SF | 9 | Week 12 |
| Jake Burger | 3B (1B) | Mia | 46 | Week 2 |
| Alec Burleson | OF (1B) | StL | 8 | Week 14 |
| Mark Canha | OF (1B) | Det | 31 | Week 5 |
| Kody Clemens | 2B (1B) | Phi | 10 | Week 14 |
| J.D. Davis | 3B (1B) | NYA | 28 | Week 3 |
| Brandon Drury | 2B (1B) | LAA | 9 | Week 6 |
| Mauricio Dubon | 2B (1B,OF) | Hou | 15 | Week 12 |
| Ezequiel Duran | 3B (1B,SS,OF) | Tex | 11 | Week 4 |
| Wilmer Flores | 2B (1B) | SF | 56 | Week 1 |
| Joey Gallo | OF (1B) | Was | 36 | Week 2 |
| Romy Gonzalez | 2B (1B,SS) | Bos | 12 | Week 14 |
| Kike Hernandez | OF (1B,SS,3B) | LAD | 5 | Week 12 |
| Andy Ibáñez | 3B (1B,2B) | Det | 11 | Week 13 |
| Connor Joe | OF (1B) | Pit | 50 | Week 3 |
| D.J. LeMahieu | 3B (1B) | NYA | 11 | Week 13 |
| Tyler Locklear | 3B (1B) | Sea | 11 | Week 12 |
| Owen Miller | 2B (1B) | Mil | 8 | Week 9 |
| Jose Miranda | 3B (1B) | Min | 6 | Week 15 |
| Elehuris Montero | 3B (1B) | Col | 52 | Week 3 |
| Isaac Paredes | 3B (1B) | TB | 15 | Week 12 |
| Salvador Perez | C (1B) | KC | 25 | Week 3 |
| Luke Raley | OF (1B) | Sea | 15 | Week 8 |
| Emmanuel Rivera | 3B (1B) | Mia | 10 | Week 5 |
| Gavin Sheets | OF (1B) | ChA | 17 | Week 4 |
| Tyler Soderstrom | C (1B) | Oak | 46 | Week 8 |
| Donovan Solano | 2B (1B,3B) | SD | 5 | Week 15 |
| Spencer Steer | OF (1B) | Cin | 50 | Week 7 |
| Justin Turner | DH (1B,3B) | Tor | 11 | Week 10 |
| David Villar | 2B (1B) | SF | 6 | Week 15 |
| Patrick Wisdom | 3B (1B,OF) | ChN | 15 | Week 8 |
| Connor Wong | C (1B) | Bos | 6 | Week 18 |
| Juan Yepez | OF (1B) | Was | 16 | Week 16 |
| 2nd Basemen | ||||
| Blaze Alexander | SS (2B,3B) | Ari | 12 | Week 9 |
| Adael Amador | SS (2B) | Col | 10 | Week 12 |
| Gabriel Arias | SS (2B,3B,OF) | Cle | 5 | Week 10 |
| Brooks Baldwin | 3B (2B) | ChA | 7 | Week 18 |
| Ryan Bliss | SS (2B) | Sea | 22 | Week 10 |
| Jose Caballero | SS (2B,3B) | TB | 12 | Week 14 |
| Oswaldo Cabrera | SS (2B,3B) | NYA | 8 | Week 15 |
| Jake Cronenworth | 1B (2B) | SD | 44 | Week 10 |
| Santiago Espinal | SS (2B,3B) | Cin | 22 | Week 3 |
| Kyle Farmer | SS (2B,3B) | Min | 38 | Week 2 |
| Tyler Fitzgerald | OF (2B,SS) | SF | 6 | Week 15 |
| Tyler Freeman | SS (2B,OF) | Cle | 5 | Week 18 |
| Maikel Garcia | 3B (2B) | KC | 12 | Week 14 |
| Nick Gordon | OF (2B) | Mia | 6 | Week 12 |
| David Hamilton | SS (2B) | Bos | 21 | Week 8 |
| Jackson Holliday | SS (2B) | Bal | 10 | Week 4 |
| Spencer Horwitz | 1B (2B) | Tor | 28 | Week 12 |
| Andy Ibáñez | 3B (1B,2B) | Det | 30 | Week 6 |
| Jose Iglesias | SS (2B,3B) | NYN | 23 | Week 11 |
| Tony Kemp | OF (2B) | Bal | 5 | Week 3 |
| Isiah Kiner-Falefa | 3B (2B,SS) | Tor | 38 | Week 3 |
| Nick Loftin | 3B (2B) | KC | 28 | Week 2 |
| Gavin Lux | SS (2B) | LAD | 84 | Week 1 |
| Curtis Mead | 3B (2B) | TB | 21 | Week 2 |
| Andruw Monasterio | 3B (2B) | Mil | 9 | Week 9 |
| Dylan Moore | 3B (2B,SS,OF) | Sea | 24 | Week 9 |
| Kevin Newman | SS (2B) | Ari | 15 | Week 5 |
| Joey Ortiz | 3B (2B) | Mil | 6 | Week 7 |
| Richie Palacios | OF (2B) | TB | 34 | Week 7 |
| Kyren Paris | SS (2B) | LAA | 17 | Week 8 |
| Ceddanne Rafaela | OF (2B,SS) | Bos | 5 | Week 4 |
| Miguel Rojas | SS (2B,3B) | LAD | 12 | Week 7 |
| Amed Rosario | SS (2B,3B,OF) | TB | 21 | Week 4 |
| Max Schuemann | OF (2B,SS) | Oak | 7 | Week 6 |
| Braden Shewmake | SS (2B,3B) | ChA | 6 | Week 6 |
| Edmundo Sosa | SS (2B,3B) | Phi | 8 | Week 14 |
| Chris Taylor | OF (2B,3B) | LAD | 13 | Week 14 |
| Abraham Toro | 3B (2B) | Oak | 17 | Week 6 |
| Alan Trejo | SS (2B) | Col | 16 | Week 4 |
| Jared Triolo | 3B (2B,SS) | Pit | 36 | Week 2 |
| Alika Williams | SS (2B) | Pit | 13 | Week 4 |
| Shortstops | ||||
| Mookie Betts | 2B (SS) | LAD | 65 | Week 1 |
| Vidal Brujan | 2B (SS,3B,OF) | Mia | 21 | Week 6 |
| Willi Castro | 2B (SS,3B,OF) | Min | 28 | Week 3 |
| Ezequiel Duran | 3B (1B,SS,OF) | Tex | 5 | Week 13 |
| Xavier Edwards | 2B (SS) | Mia | 21 | Week 15 |
| Tyler Fitzgerald | OF (2B,SS) | SF | 15 | Week 7 |
| Romy Gonzalez | 2B (1B,SS) | Bos | 17 | Week 7 |
| Gunnar Henderson | 3B (SS) | Bal | 99 | Week 2 |
| Kike Hernandez | OF (1B,SS,3B) | LAD | 9 | Week 16 |
| Nico Hoerner | 2B (SS) | ChN | 10 | Week 7 |
| Leo Jimenez | 3B (SS) | Tor | 12 | Week 16 |
| Isiah Kiner-Falefa | 3B (2B,SS) | Tor | 15 | Week 12 |
| Nicky Lopez | 2B (SS) | ChA | 15 | Week 13 |
| Miles Mastrobuoni | 2B (SS,3B) | ChN | 9 | Week 8 |
| Jorge Mateo | 2B (SS) | Bal | 6 | Week 13 |
| Zach McKinstry | 2B (SS,3B,OF) | Det | 35 | Week 6 |
| Dylan Moore | 3B (2B,SS,OF) | Sea | 32 | Week 5 |
| Nasim Nunez | 2B (SS) | Was | 10 | Week 9 |
| Jace Peterson | 2B (SS) | Ari | 5 | Week 4 |
| Ceddanne Rafaela | OF (2B,SS) | Bos | 53 | Week 5 |
| Daniel Schneemann | 3B (SS,OF) | Cle | 13 | Week 14 |
| Max Schuemann | OF (2B,SS) | Oak | 66 | Week 7 |
| Zack Short | 3B (SS) | Atl | 7 | Week 15 |
| Josh Smith | 3B (SS) | Tex | 22 | Week 4 |
| Bryson Stott | 2B (SS) | Phi | 12 | Week 8 |
| Jared Triolo | 3B (2B,SS) | Pit | 9 | Week 15 |
| Ildemaro Vargas | 2B (SS,3B,OF) | Was | 7 | Week 10 |
| Brett Wisely | 2B (SS) | SF | 30 | Week 10 |
| 3rd Basemen | ||||
| Ehire Adrianza | SS (3B) | LAA | 6 | Week 6 |
| Blaze Alexander | SS (2B,3B) | Ari | 7 | Week 12 |
| Gabriel Arias | SS (2B,3B,OF) | Cle | 18 | Week 4 |
| Addison Barger | OF (3B) | Tor | 9 | Week 13 |
| Jon Berti | SS (3B) | NYA | 16 | Week 3 |
| Cavan Biggio | 2B (1B,3B,OF) | LAD | 18 | Week 12 |
| David Bote | 2B (3B) | ChN | 11 | Week 13 |
| Vidal Brujan | 2B (SS,3B,OF) | Mia | 14 | Week 5 |
| Jose Caballero | SS (2B,3B) | TB | 13 | Week 13 |
| Oswaldo Cabrera | SS (2B,3B) | NYA | 58 | Week 2 |
| Jeimer Candelario | 1B (3B) | Cin | 54 | Week 2 |
| Willi Castro | 2B (SS,3B,OF) | Min | 22 | Week 2 |
| Ernie Clement | SS (3B) | Tor | 62 | Week 2 |
| Brandon Crawford | SS (3B) | StL | 5 | Week 16 |
| Bobby Dalbec | 1B (3B) | Bos | 13 | Week 3 |
| Paul DeJong | SS (3B) | ChA | 7 | Week 18 |
| Brendan Donovan | 2B (3B,OF) | StL | 9 | Week 9 |
| Santiago Espinal | SS (2B,3B) | Cin | 39 | Week 4 |
| Kyle Farmer | SS (2B,3B) | Min | 22 | Week 3 |
| Luis Guillorme | 2B (3B) | LAA | 12 | Week 10 |
| Darell Hernaiz | SS (3B) | Oak | 15 | Week 2 |
| Kike Hernandez | OF (1B,SS,3B) | LAD | 41 | Week 6 |
| Jose Iglesias | SS (2B,3B) | NYN | 13 | Week 15 |
| Brooks Lee | SS (3B) | Min | 11 | Week 16 |
| Otto Lopez | 2B (3B) | Mia | 6 | Week 6 |
| Nick Madrigal | 2B (3B) | ChN | 25 | Week 2 |
| Miles Mastrobuoni | 2B (SS,3B) | ChN | 13 | Week 16 |
| Zach McKinstry | 2B (SS,3B,OF) | Det | 19 | Week 3 |
| Danny Mendick | 2B (3B) | ChA | 25 | Week 5 |
| Whit Merrifield | 2B (3B,OF) | Atl | 12 | Week 7 |
| Christopher Morel | OF (3B) | ChN | 73 | Week 2 |
| Tyler Nevin | 1B (3B,OF) | Oak | 18 | Week 5 |
| Luis Rengifo | 2B (3B) | LAA | 44 | Week 5 |
| Pablo Reyes | 2B (3B) | Bos | 11 | Week 4 |
| Josh Rojas | 2B (3B,OF) | Sea | 80 | Week 2 |
| Miguel Rojas | SS (2B,3B) | LAD | 9 | Week 10 |
| Amed Rosario | SS (2B,3B,OF) | TB | 14 | Week 10 |
| Eguy Rosario | SS (3B) | SD | 25 | Week 1 |
| Miguel Sano | 1B (3B) | LAA | 14 | Week 5 |
| Braden Shewmake | SS (2B,3B) | ChA | 7 | Week 6 |
| Donovan Solano | 2B (1B,3B) | SD | 25 | Week 9 |
| Edmundo Sosa | SS (2B,3B) | Phi | 10 | Week 13 |
| Lenyn Sosa | 2B (3B) | ChA | 40 | Week 3 |
| Chris Taylor | OF (2B,3B) | LAD | 22 | Week 11 |
| Cole Tucker | SS (3B,OF) | LAA | 9 | Week 7 |
| Justin Turner | DH (1B,3B) | Tor | 5 | Week 7 |
| Ramon Urias | SS (3B) | Bal | 51 | Week 2 |
| Giovanny Urshela | 1B (3B) | Det | 58 | Week 2 |
| Ildemaro Vargas | 2B (SS,3B,OF) | Was | 27 | Week 5 |
| Matt Vierling | OF (3B) | Det | 39 | Week 4 |
| Tyler Wade | 2B (3B,OF) | SD | 26 | Week 1 |
| Joey Wendle | 2B (3B) | Atl | 5 | Week 8 |
| Jordan Westburg | 2B (3B) | Bal | 64 | Week 3 |
| Outfielders | ||||
| Miguel Andújar | 3B (OF) | Oak | 49 | Week 10 |
| Gabriel Arias | SS (2B,3B,OF) | Cle | 8 | Week 6 |
| Ji Hwan Bae | 2B (OF) | Pit | 7 | Week 10 |
| Jake Bauers | 1B (OF) | Mil | 14 | Week 7 |
| Cavan Biggio | 2B (1B,3B,OF) | LAD | 13 | Week 6 |
| Seth Brown | 1B (OF) | Oak | 58 | Week 2 |
| Vidal Brujan | 2B (SS,3B,OF) | Mia | 13 | Week 12 |
| Kris Bryant | 1B (OF) | Col | 5 | Week 18 |
| Trey Cabbage | 1B (OF) | Hou | 28 | Week 8 |
| Willi Castro | 2B (SS,3B,OF) | Min | 40 | Week 6 |
| Brendan Donovan | 2B (3B,OF) | StL | 82 | Week 1 |
| Mauricio Dubon | 2B (1B,OF) | Hou | 54 | Week 3 |
| Ezequiel Duran | 3B (1B,SS,OF) | Tex | 13 | Week 7 |
| Adam Frazier | 2B (OF) | KC | 18 | Week 6 |
| Tyler Freeman | SS (2B,OF) | Cle | 82 | Week 2 |
| David Fry | 1B (C,OF) | Cle | 20 | Week 7 |
| Sam Haggerty | 2B (OF) | Sea | 6 | Week 7 |
| Garrett Hampson | 2B (OF) | KC | 47 | Week 2 |
| Jahmai Jones | 2B (OF) | NYA | 10 | Week 12 |
| Alex Kirilloff | 1B (OF) | Min | 30 | Week 3 |
| Justyn-Henry Malloy | 3B (OF) | Det | 10 | Week 13 |
| Angel Martinez | 2B (OF) | Cle | 15 | Week 16 |
| Zach McKinstry | 2B (SS,3B,OF) | Det | 9 | Week 11 |
| Jeff McNeil | 2B (OF) | NYN | 16 | Week 5 |
| Whit Merrifield | 2B (3B,OF) | Atl | 26 | Week 3 |
| Jackson Merrill | SS (OF) | SD | 99 | Week 1 |
| Dylan Moore | 3B (2B,SS,OF) | Sea | 21 | Week 3 |
| Tyler Nevin | 1B (3B,OF) | Oak | 26 | Week 3 |
| Jhonkensy Noel | 1B (OF) | Cle | 14 | Week 15 |
| Ryan O'Hearn | 1B (OF) | Bal | 17 | Week 7 |
| Rob Refsnyder | 2B (OF) | Bos | 46 | Week 5 |
| Josh Rojas | 2B (3B,OF) | Sea | 6 | Week 7 |
| Amed Rosario | SS (2B,3B,OF) | TB | 18 | Week 2 |
| Daniel Schneemann | 3B (SS,OF) | Cle | 21 | Week 13 |
| Davis Schneider | 2B (OF) | Tor | 64 | Week 2 |
| Michael Toglia | 1B (OF) | Col | 15 | Week 4 |
| Cole Tucker | SS (3B,OF) | LAA | 8 | Week 11 |
| Ildemaro Vargas | 2B (SS,3B,OF) | Was | 15 | Week 8 |
| Miguel Vargas | 2B (OF) | LAD | 26 | Week 10 |
| Ryan Vilade | SS (OF) | Det | 7 | Week 16 |
| Tyler Wade | 2B (3B,OF) | SD | 9 | Week 13 |
| LaMonte Wade Jr | 1B (OF) | SF | 11 | Week 2 |
| Weston Wilson | 1B (OF) | Phi | 6 | Week 18 |
| Patrick Wisdom | 3B (1B,OF) | ChN | 5 | Week 18 |
| Starting Pitchers | ||||
| Shawn Armstrong | RP (SP) | TB | 6 | Week 5 |
| Ronel Blanco | RP (SP) | Hou | 19 | Week 3 |
| Aaron Brooks | RP (SP) | Oak | 4 | Week 9 |
| Davis Daniel | RP (SP) | LAA | 3 | Week 16 |
| Bowden Francis | RP (SP) | Tor | 3 | Week 11 |
| Tyler Holton | RP (SP) | Det | 3 | Week 18 |
| Carmen Mlodzinski | RP (SP) | Pit | 3 | Week 13 |
| Andre Pallante | RP (SP) | StL | 9 | Week 11 |
| José Soriano | RP (SP) | LAA | 16 | Week 4 |
| Albert Suarez | RP (SP) | Bal | 13 | Week 5 |
| Kyle Tyler | RP (SP) | Mia | 4 | Week 15 |
| Garrett Whitlock | RP (SP) | Bos | 4 | Week 3 |
| Rob Zastryzny | RP (SP) | Mil | 3 | Week 18 |
| Relief Pitchers | ||||
| Tyler Alexander | SP (RP) | TB | 6 | Week 5 |
| Logan Allen | SP (RP) | Ari | 12 | Week 6 |
| Chase Anderson | SP (RP) | Bos | 25 | Week 3 |
| Tejay Antone | SP (RP) | Cin | 4 | Week 2 |
| Pedro Avila | SP (RP) | Cle | 29 | Week 2 |
| Anthony Banda | SP (RP) | LAD | 26 | Week 9 |
| Brady Basso | SP (RP) | Oak | 3 | Week 12 |
| Tyler Beede | SP (RP) | Cle | 13 | Week 2 |
| Jalen Beeks | SP (RP) | Col | 45 | Week 2 |
| Osvaldo Bido | SP (RP) | Oak | 6 | Week 15 |
| Brandon Bielak | SP (RP) | Oak | 13 | Week 2 |
| Hunter Bigge | SP (RP) | ChN | 4 | Week 16 |
| Spencer Bivens | SP (RP) | SF | 6 | Week 13 |
| Ty Blach | SP (RP) | Col | 7 | Week 7 |
| Ryan Borucki | SP (RP) | Pit | 4 | Week 1 |
| Beau Brieske | SP (RP) | Det | 21 | Week 9 |
| Jhony Brito | SP (RP) | SD | 25 | Week 1 |
| Ben Brown | SP (RP) | ChN | 7 | Week 4 |
| Kris Bubic | SP (RP) | KC | 5 | Week 16 |
| Brock Burke | SP (RP) | Tex | 10 | Week 2 |
| José Butto | SP (RP) | NYN | 7 | Week 16 |
| Génesis Cabrera | SP (RP) | Tor | 43 | Week 2 |
| Andrew Chafin | SP (RP) | Det | 40 | Week 2 |
| Angel Chivilli | SP (RP) | Col | 5 | Week 11 |
| Jose Cisnero | SP (RP) | LAA | 14 | Week 1 |
| Luis Contreras | SP (RP) | Hou | 5 | Week 14 |
| Roansy Contreras | SP (RP) | LAA | 25 | Week 2 |
| Hans Crouse | SP (RP) | LAA | 15 | Week 14 |
| Enyel De Los Santos | SP (RP) | SD | 43 | Week 1 |
| Tyler Duffey | SP (RP) | KC | 9 | Week 6 |
| Dane Dunning | SP (RP) | Tex | 3 | Week 15 |
| Alex Faedo | SP (RP) | Det | 30 | Week 2 |
| Buck Farmer | SP (RP) | Cin | 36 | Week 2 |
| Tyler Ferguson | SP (RP) | Oak | 19 | Week 7 |
| Josh Fleming | SP (RP) | Pit | 22 | Week 2 |
| Carson Fulmer | SP (RP) | LAA | 24 | Week 4 |
| Hunter Gaddis | SP (RP) | Cle | 50 | Week 1 |
| Gerson Garabito | SP (RP) | Tex | 3 | Week 18 |
| Deivi Garcia | SP (RP) | ChA | 14 | Week 1 |
| Yoendrys Gomez | SP (RP) | NYA | 4 | Week 14 |
| Jonathan Gray | SP (RP) | Tex | 3 | Week 17 |
| Michael Grove | SP (RP) | LAD | 26 | Week 2 |
| Jon Heasley | SP (RP) | Bal | 4 | Week 3 |
| Kyle Hendricks | SP (RP) | ChN | 5 | Week 10 |
| Elieser Hernandez | SP (RP) | Mil | 8 | Week 9 |
| Porter Hodge | SP (RP) | ChN | 17 | Week 9 |
| Bryan Hoeing | SP (RP) | Mia | 13 | Week 2 |
| Grant Holmes | SP (RP) | Atl | 10 | Week 13 |
| Brent Honeywell | SP (RP) | LAD | 5 | Week 17 |
| Adrian Houser | SP (RP) | NYN | 16 | Week 9 |
| Spencer Howard | SP (RP) | Cle | 6 | Week 13 |
| Cole Irvin | SP (RP) | Bal | 5 | Week 15 |
| Daulton Jefferies | SP (RP) | Pit | 5 | Week 14 |
| Jake Junis | SP (RP) | Mil | 8 | Week 14 |
| Janson Junk | SP (RP) | Mil | 3 | Week 6 |
| Brad Keller | SP (RP) | Bos | 12 | Week 7 |
| Bryan King | SP (RP) | Hou | 10 | Week 14 |
| Will Klein | SP (RP) | KC | 5 | Week 10 |
| Jared Koenig | SP (RP) | Mil | 26 | Week 5 |
| Stephen Kolek | SP (RP) | SD | 40 | Week 1 |
| Chad Kuhl | SP (RP) | ChA | 8 | Week 13 |
| Peter Lambert | SP (RP) | Col | 17 | Week 2 |
| Dinelson Lamet | SP (RP) | LAD | 3 | Week 2 |
| Jake Latz | SP (RP) | Tex | 42 | Week 2 |
| Jordan Leasure | SP (RP) | ChA | 33 | Week 2 |
| Mark Leiter Jr. | SP (RP) | ChN | 38 | Week 2 |
| Matthew Liberatore | SP (RP) | StL | 28 | Week 2 |
| Jonathan Loaisiga | SP (RP) | NYA | 3 | Week 2 |
| Sammy Long | SP (RP) | KC | 21 | Week 10 |
| Jacob Lopez | SP (RP) | TB | 3 | Week 6 |
| Jordan Lyles | SP (RP) | KC | 5 | Week 3 |
| Anthony Maldonado | SP (RP) | Mia | 10 | Week 6 |
| Nick Martinez | SP (RP) | Cin | 23 | Week 6 |
| Tyler Matzek | SP (RP) | Atl | 11 | Week 2 |
| Darren McCaughan | SP (RP) | Cle | 3 | Week 14 |
| Erik Miller | SP (RP) | SF | 38 | Week 1 |
| Anthony Molina | SP (RP) | Col | 21 | Week 3 |
| Adrian Morejon | SP (RP) | SD | 33 | Week 4 |
| Eli Morgan | SP (RP) | Cle | 12 | Week 1 |
| Kyle Muller | SP (RP) | Oak | 16 | Week 2 |
| Sean Newcomb | SP (RP) | Oak | 7 | Week 12 |
| Kyle Nicolas | SP (RP) | Pit | 29 | Week 6 |
| Dedniel Nunez | SP (RP) | NYN | 24 | Week 6 |
| Jack O'Loughlin | SP (RP) | Oak | 4 | Week 11 |
| Luis Ortiz | SP (RP) | Pit | 22 | Week 2 |
| Michel Otanez | SP (RP) | Oak | 7 | Week 16 |
| Quinn Priester | SP (RP) | Pit | 3 | Week 17 |
| AJ Puk | SP (RP) | Mia | 28 | Week 8 |
| Brooks Raley | SP (RP) | NYN | 8 | Week 2 |
| Emmanuel Ramirez | SP (RP) | Mia | 7 | Week 6 |
| Erasmo Ramirez | SP (RP) | TB | 11 | Week 5 |
| Colin Rea | SP (RP) | Mil | 3 | Week 16 |
| Sean Reid-Foley | SP (RP) | NYN | 23 | Week 5 |
| Trevor Richards | SP (RP) | Tor | 42 | Week 1 |
| Randy Rodraguez | SP (RP) | SF | 28 | Week 8 |
| Josh Rogers | SP (RP) | Col | 5 | Week 11 |
| Landen Roupp | SP (RP) | SF | 11 | Week 2 |
| Chris Roycroft | SP (RP) | StL | 21 | Week 7 |
| Ryder Ryan | SP (RP) | Pit | 13 | Week 2 |
| Sixto Sánchez | SP (RP) | Mia | 7 | Week 2 |
| Tony Santillan | SP (RP) | Cin | 4 | Week 17 |
| Jared Shuster | SP (RP) | ChA | 20 | Week 6 |
| Justin Slaten | SP (RP) | Bos | 31 | Week 2 |
| Burch Smith | SP (RP) | Bal | 29 | Week 2 |
| Drew Smyly | SP (RP) | ChN | 26 | Week 2 |
| Mike Soroka | SP (RP) | ChA | 13 | Week 9 |
| Mitch Spence | SP (RP) | Oak | 11 | Week 3 |
| Carson Spiers | SP (RP) | Cin | 5 | Week 9 |
| Jackson Stephens | SP (RP) | Atl | 3 | Week 8 |
| Chris Stratton | SP (RP) | KC | 39 | Week 2 |
| José Suarez | SP (RP) | LAA | 17 | Week 2 |
| Brent Suter | SP (RP) | Cin | 35 | Week 1 |
| Erik Swanson | SP (RP) | Tor | 19 | Week 5 |
| Kai-Wei Teng | SP (RP) | SF | 4 | Week 3 |
| Keegan Thompson | SP (RP) | ChN | 13 | Week 4 |
| Zack Thompson | SP (RP) | StL | 3 | Week 5 |
| Trent Thornton | SP (RP) | Sea | 45 | Week 2 |
| Spencer Turnbull | SP (RP) | Phi | 10 | Week 8 |
| Edwin Uceta | SP (RP) | TB | 9 | Week 14 |
| Jose Urena | SP (RP) | Tex | 18 | Week 2 |
| Eli Villalobos | SP (RP) | Mia | 3 | Week 7 |
| Austin Voth | SP (RP) | Sea | 45 | Week 2 |
| Luke Weaver | SP (RP) | NYA | 38 | Week 2 |
| Joey Wentz | SP (RP) | Det | 29 | Week 2 |
| Hayden Wesneski | SP (RP) | ChN | 18 | Week 8 |
| Bryse Wilson | SP (RP) | Mil | 16 | Week 2 |
| Josh Winckowski | SP (RP) | Bos | 13 | Week 2 |
| Cole Winn | SP (RP) | Tex | 13 | Week 5 |
| Ryan Yarbrough | SP (RP) | LAD | 31 | Week 2 |
| Alex Young | SP (RP) | NYN | 5 | Week 10 |
| Angel Zerpa | SP (RP) | KC | 43 | Week 2 |
| There are no players that have qualified for new positions yet. | ||||