| My Bad - ML17 | Glacier Range Riders - ML17 |
| Week 2 | |
|
SP Zack Greinke F/A OF Andrew McCutchen Pit |
SS Dansby Swanson ChN |
| The trade was approved 13-1. See Breakdown | |
| Mama's Boys - ML12 | Dave's Destroyers III - ML12 |
| Week 5 | |
|
C Francisco Mejia F/A |
SS Adalberto Mondesà F/A SP Aaron Sanchez F/A |
| The trade was approved 13-1. See Breakdown | |
| Bad Reputation - ML17 | Glacier Range Riders - ML17 |
| Week 5 | |
|
2B Chad Pinder F/A |
SP Zach Eflin TB OF Tyler O'Neill Bos 1B Luke Voit F/A |
| The trade was approved 13-0. See Breakdown | |
| High Point Rockers - ML17 | Bad Reputation - ML17 |
| Week 7 | |
|
SP Domingo German F/A 1B Yandy Diaz TB OF Fernando Tatis Jr. SD |
SP Eduardo Rodriguez Ari OF Austin Meadows F/A OF Brandon Nimmo NYN 3B Nick Senzel Was |
| The trade was approved 14-1. See Breakdown | |
| Midnight Run - ML29 | Mary & Mart - ML29 |
| Week 10 | |
|
SP Rich Hill F/A OF Andrew McCutchen Pit SP Danny Duffy Tex SP Frankie Montas Cin |
SP Max Fried Atl 2B Jorge Polanco Sea 2B Brendan Rodgers Col |
| The trade was approved 13-0. See Breakdown | |
| Gizzy - ML12 | Mama's Boys - ML12 |
| Week 12 | |
|
RP Greg Holland F/A 2B Ketel Marte Ari 2B Michael Chavis Sea |
OF David Dahl Phi 3B Ryan McMahon Col 2B Brendan Rodgers Col |
| The trade was approved 15-3. See Breakdown | |
| 4dogs - ML2 | Long Island Generals - ML2 |
| Week 13 | |
|
SP Gerrit Cole NYA |
3B Matt Chapman SF 2B Keston Hiura Det OF Oscar Mercado SD |
| The trade was approved 11-0. See Breakdown | |
| Modus Hoperandi - EL3 | Natural Grass - EL3 |
| Week 14 | |
|
SP Justin Verlander Hou |
3B Jose Ramirez Cle |
| The trade was approved 8-4. See Breakdown | |
| Horseheads Buffalos - EL13 | Ace's Full - EL13 |
| Week 14 | |
|
SP Rich Hill F/A OF Derek Fisher F/A 1B Kevin Cron F/A |
SP Carlos Martinez F/A |
| The trade was approved 10-0. See Breakdown | |
| Dodgers - EL19 | Wisdom - EL19 |
| Week 14 | |
|
SP Corey Kluber F/A C Austin Barnes LAD OF Franmil Reyes F/A |
3B Hunter Dozier LAA |
| The trade was approved 12-0. See Breakdown | |
| That’s What She Said - ML22 | Frisco RoughRiders - ML22 |
| Week 14 | |
|
2B Mike Moustakas F/A RP Kenley Jansen Bos SP Pat Corbin Was |
SP Corey Kluber F/A RP Blake Treinen LAD OF Jo Adell LAA SP Dylan Cease SD |
| The trade was approved 10-0. See Breakdown | |